Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Anna Mae Diehl, Tianyi Chen
Publikováno v:
Hepatology
Acute liver damage causes hepatocyte stress and death, but in chronic liver disease impaired hepatocyte regeneration and immune cell infiltration prevents recovery. While the roles of both impaired liver regeneration and immune infiltration have been
Autor:
Raquel Maeso‐Díaz, George D. Dalton, Sehhoon Oh, Kuo Du, Linda Tang, Tianyi Chen, Rajesh K. Dutta, Jessica H. Hartman, Joel N. Meyer, Anna Mae Diehl
Publikováno v:
Aging Cell. 21
Older age is a major risk factor for damage to many tissues, including liver. Aging undermines resiliency and impairs liver regeneration. The mechanisms whereby aging reduces resiliency are poorly understood. Hedgehog is a signaling pathway with crit
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 22 (2020)
JCI Insight, Vol 5, Iss 22 (2020)
Adult liver has enormous regenerative capacity; it can regenerate after losing two-thirds of its mass while sustaining essential metabolic functions. How the liver balances dual demands for increased proliferative activity with maintenance of organ f
Autor:
Gregory A. Michelotti, Mark L. Jewell, Marzena Swiderska-Syn, Richard T. Premont, Anna Mae Diehl, Guanhua Xie, Wing-Kin Syn
Publikováno v:
Hepatology. 64:232-244
Introduction: Adult liver regeneration requires induction and suppression of proliferative activity in multiple types of liver cells. The mechanisms that orchestrate the global changes in gene expression that are required for proliferative activity t
Background & Aims Chronic failure of mechanisms that promote effective regeneration of dead hepatocytes causes replacement of functional hepatic parenchyma with fibrous scar tissue, ultimately resulting in cirrhosis. Therefore, defining and optimizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0ff2fc8ab0f7b47c91ca971b7fe6e3
https://europepmc.org/articles/PMC6349217/
https://europepmc.org/articles/PMC6349217/
Autor:
Anna Mae Diehl, Gregory A. Michelotti, Cynthia D. Guy, Thiago A. Pereira, Mariana Verdelho Machado, Ann Marie Zavacki, Dawn Piercy, Leandi Krüger, Manal F. Abdelmalek, Brittany N. Bohinc, Herbert Pang, Guanhua Xie, Marzena Swiderska-Syn, Ayako Suzuki
Publikováno v:
Endocrinology
Thyroid hormone (TH) is important for tissue repair because it regulates cellular differentiation. Intrahepatic TH activity is controlled by both serum TH levels and hepatic deiodinases. TH substrate (T4) is converted into active hormone (T3) by deio
Publikováno v:
Mayo Clinic Proceedings. 89:120-130
Cirrhosis and liver cancer, the main causes of liver-related morbidity and mortality, result from defective repair of liver injury. This article summarizes rapidly evolving knowledge about liver myofibroblasts and progenitors, the 2 key cell types th
Publikováno v:
Journal of Clinical Investigation. 128:2192-2193
The liver's extraordinary ability to regenerate has been known since the myth of Prometheus, but the mechanisms involved are still being discovered. Various small animal models have been used in this quest. Two of the most popular include partial hep
Autor:
Anna Mae Diehl, Mariana Verdelho Machado, Marzena Swiderska-Syn, Wing-Kin Syn, Richard T. Premont, Gamze Karaca, Leandi Krüger, Guanhua Xie, Steve S. Choi, Gregory A. Michelotti
Publikováno v:
Gut. 63:1333-1344
Objective Smoothened (SMO), a coreceptor of the Hedgehog (Hh) pathway, promotes fibrogenic repair of chronic liver injury. We investigated the roles of SMO+ myofibroblast (MF) in liver regeneration by conditional deletion of SMO in α smooth muscle a
Autor:
Seh-Hoon Oh, Rolf Gebhardt, Bianca Loeffler, Madlen Matz, George D. Dalton, Richard T. Premont, Anna Mae Diehl
Publikováno v:
Gastroenterology. 154:S-166