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pro vyhledávání: '"Daniel S. Marsman"'
Publikováno v:
Carcinogenesis. 16:77-82
Transforming growth factor alpha (TGF alpha) is a mitogenic growth factor for hepatocytes that may play a role in the development of liver cancer in rodents and humans. Epidermal growth factor receptor (EGFR) is the receptor for TGF alpha; its expres
Autor:
Daniel S. Marsman, James A. Popp
Publikováno v:
Carcinogenesis. 15:111-117
The biological potential of hepatic foci and tumors induced by peroxisome proliferators such as Wy-14,643 has been poorly characterized. In this study, male F-344 rats (n = 20/group/time point) were fed Wy-14,643 (0.1%) for 22, 37 or 52 weeks ('W-22'
Autor:
Daniel S. Marsman, J. Carl Barrett
Publikováno v:
Risk analysis : an official publication of the Society for Risk Analysis. 14(3)
Long recognized as a normal component of organogenesis during development, apoptosis (programmed cell death) has recently been implicated in alterations of cell growth and differentiation. Tissue homeostasis is normally maintained by a balance betwee
Publikováno v:
Carcinogenesis. 13(6)
Earlier studies indicated that the hepatocarcinogenic activity of two peroxisome proliferators (PP) Wy-14,643 and di(2-ethylhexyl)phthalate (DEHP) correlated to the degree of lipofuscin accumulation and sustained cell replication rather than the leve
Publikováno v:
Carcinogenesis. 12(3)
The carcinogenicity of the peroxisome proliferator WY-14,643 was compared in young (starting age 2 months) and old (starting age 15 months) rats. Old rats had a 5- to 7-fold higher yield of grossly visible hepatic tumors following 22 weeks of dietary
Autor:
James A. Popp, Daniel S. Marsman, Konrad E. Tomaszewski, Russell C. Cattley, Michael J. Olson, James G. Conway
Publikováno v:
Carcinogenesis. 10:513-519
Quantitative comparisons of the time course of biochemical and morphological changes induced by peroxisome proliferators resulting in low and high incidences of hepatic cancer have not been conducted previously under bioassay conditions. [4-Chloro-6-