Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ayako Suzuki"'
Autor:
M. Isabel Lucena, Kristin Ashby, Minjun Chen, Ismael Alvarez-Alvarez, A. González-Jiménez, Raúl J. Andrade, Ayako Suzuki
Publikováno v:
Archives of Toxicology. 95:1793-1803
Drug-induced liver injury (DILI) presentation varies biochemically and histologically. Certain drugs present quite consistent injury patterns, i.e., DILI signatures. In contrast, others are manifested as broader types of liver injury. The variety of
Autor:
Jun Zhang, Roger J. Davis, Meng Li, Christopher Q. Chen, Anna Mae Diehl, Mariam Aghajan, Ying Wang, Robert Win Maw Min, Tin Aung Than, Sanda Win, Neil Kaplowitz, Yibu Chen, Manal F. Abdelmalek, Filbert W.M. Aung, Ayako Suzuki
Publikováno v:
Journal of Clinical Investigation. 129:5278-5293
SH3 domain–binding protein that preferentially associates with Btk (SAB) is an outer-membrane docking protein for JNK-mediated impairment of mitochondrial function. Deletion of Sab in hepatocytes inhibits sustained JNK activation and cell death. Th
Autor:
M. Isabel Lucena, Ayako Suzuki, Guruprasad P. Aithal, Wei Zhuang, Ismael Alvarez-Alvarez, Raúl J. Andrade, Minjun Chen, Kristin Ashby, A. González-Jiménez
Background & Aims Although most drug-induced liver injury (DILI) cases resolve after the offending medication is discontinued, time to recovery varies among patients, with 6 –12% developing a chronic disease. Herein, we investigated clinical factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3578991979abe73ea57f1ec078598bd
https://hdl.handle.net/10668/17566
https://hdl.handle.net/10668/17566
ObjectiveWe hypothesized that a drug-characteristic DILI-phenotype could be defined and be used to develop a computer-assisted DILI causality assessment-tool (DILI-CAT).DesignA drug-specific DILI-phenotype was developed for amoxicillin-clavulanate (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::215bb8e8b153155fbc417b489fcaed62
https://doi.org/10.1101/2021.03.05.21252982
https://doi.org/10.1101/2021.03.05.21252982
Autor:
Einar Bjornsson, M. Isabel Lucena, Harshad Devarbhavi, Naga Chalasani, Paul B. Watkins, Guruprasad P. Aithal, Gerd A. Kullak-Ublick, Neil Kaplowitz, Michael Merz, Ayako Suzuki, Raúl J. Andrade
Publikováno v:
Practical Gastroenterology and Hepatology: Liver and Biliary Disease
Drug-induced liver injury (DILI) is an adverse reaction to drugs or other xenobiotics that occurs either as a predictable event when an individual is exposed to toxic doses of some compounds or as an unpredictable event with many drugs in common use.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af89bb1cb1b52dfb0b84b9da71d37031
https://www.zora.uzh.ch/id/eprint/180564/
https://www.zora.uzh.ch/id/eprint/180564/
Autor:
Mercedes Robles-Díaz, Camilla Stephens, Inmaculada Medina-Caliz, Kristin McEuen, A. González-Jiménez, Minjun Chen, M.I. Lucena, Raúl J. Andrade, Ayako Suzuki, Alejandro Cueto-Sanchez
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO4-9
Autor:
Robert J. Fontana, Ayako Suzuki, Huiman X. Barnhart, Jiezhun Gu, Herbert L. Bonkovsky, Hans L. Tillmann, David E. Kleiner
Publikováno v:
Liver International. 37:1723-1730
Background and aim Gender and menopause may contribute to type and severity of drug-induced liver injury (DILI) by influencing host responses to injury. The aim of this study was to assess the associations of gender and female age 50 [a proxy of meno
Autor:
Mercedes Robles-Díaz, Camilla Stephens, Inmaculada Medina-Caliz, Minjun Chen, M. Isabel Lucena, A. González-Jiménez, Raymundo Paraná, Raúl J. Andrade, Kristin McEuen, Nelia Hernández, Marco Arrese, Ayako Suzuki, Fernando Bessone
Publikováno v:
Liver International.
BACKGROUND & AIMS Most patients with drug-induced liver injury (DILI) manifest clinical symptoms while on therapy, while some patients manifest days or weeks after drug cessation (delayed onset). This challenges DILI causality assessment and diagnosi
Autor:
Christine M. Hunt, Jeffrey I. Ambroso, Katarina Ilic, Ayako Suzuki, J. Gregory Falls, H. Roger Brown, Nancy A. Yuen, Richard T. Miller, Melinda J. Reese
Publikováno v:
Regulatory Toxicology and Pharmacology. 72:481-490
Polypharmacy is common, and may modify mechanisms of drug-induced liver injury. We examined the effect of these drug-drug interactions on liver safety reports of four drugs highly associated with hepatotoxicity. In the WHO VigiBase™, liver event re
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 94
We examined the effect of gender, age, and drug properties on liver events reporting frequency (RF) to assess patient- and drug-related risks for drug-induced liver injury (DILI). We performed a data-mining analysis of the WHO VigiBase™ to 1) ident