Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Jun Zhang, Roger J. Davis, Meng Li, Christopher Q. Chen, Anna Mae Diehl, Mariam Aghajan, Ying Wang, Robert Win Maw Min, Tin Aung Than, Sanda Win, Neil Kaplowitz, Yibu Chen, Manal F. Abdelmalek, Filbert W.M. Aung, Ayako Suzuki
Publikováno v:
Journal of Clinical Investigation. 129:5278-5293
SH3 domain–binding protein that preferentially associates with Btk (SAB) is an outer-membrane docking protein for JNK-mediated impairment of mitochondrial function. Deletion of Sab in hepatocytes inhibits sustained JNK activation and cell death. Th
Autor:
Rajesh Kumar Dutta, Seh-Hoon Oh, Wen-Hsuan Yang, Jen-Tsan Ashley Chi, Kuo Du, Anna Mae Diehl, Tianai Sun
Publikováno v:
Liver Int
Background & aims The outcome of liver injury is dictated by factors that control the accumulation of myofibroblastic (activated) hepatic stellate cells (MF-HSCs) but therapies that specifically block this process have not been discovered. We evaluat
Autor:
Wing-Kin Syn, Keyur Patel, Cynthia D. Guy, Anna Mae Diehl, Robert D. Streilein, Ricardo Henao, Oliver Glass, Hans J Gruss, Manal F. Abdelmalek, Cynthia A. Moylan, Russell P. Hall
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
The severity of hepatic fibrosis is the primary predictor of liver‐related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD‐associated fibrosis are limited. W
Background and AimsLiver fibrosis develops in the context of excessive oxidative stress, cell death and accumulation of myofibroblasts (MFs) derived from hepatic stellate cells (HSCs). Ferroptosis is a type of regulated cell death that can be caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef9c6e3dd3130b4a811e359e407a456
https://doi.org/10.1101/2019.12.23.886259
https://doi.org/10.1101/2019.12.23.886259
Publikováno v:
Journal of Hepatology. 68:550-562
Liver disease remains a leading cause of mortality worldwide despite recent successes in the field of viral hepatitis, because increases in alcohol consumption and obesity are fuelling an epidemic of chronic fatty liver disease for which there are cu
Autor:
Stephen H. Caldwell, Saumya Jayakumar, Anna Mae Diehl, G. Mani Subramanian, Ling Han, John G. McHutchison, Zachary Goodman, Nezam H. Afdhal, C. Stephen Djedjos, Eric Lawitz, Parvez S. Mantry, Rohit Loomba, Hays Arnold, Robert P. Myers, Michael Charlton
Publikováno v:
Hepatology. 67:549-559
Inhibition of apoptosis signal-regulating kinase 1, a serine/threonine kinase, leads to improvement in inflammation and fibrosis in animal models of nonalcoholic steatohepatitis. We evaluated the safety and efficacy of selonsertib, a selective inhibi
Autor:
Rasha Younis, Zhiyong Mi, Anna Mae Diehl, Paul C. Kuo, Marzena Swiderska-Syn, Naoto Kitamura, D. Reid, Lee C. Claridge, Lars P. Bechmann, Kosha J. Mehta, Jason D. Coombes, Karine Gauthier, Paul Manka, G. Gerken, MA Briones, W.-K. Syn, F Flamant, Ali Canbay, Bertus Eksteen, Roger Williams
Publikováno v:
Zeitschrift für Gastroenterologie. 54:1343-1404
Thyroid hormone (TH) signaling is critical for tissue-organ development, growth, differentiation and metabolism, and in the liver, the most widely expressed TH receptor is TRβ. In a recent study of patients with nonalcoholic steatohepatitis (NASH),
Autor:
Hays Arnold, Robert P. Myers, Saumya Jayakumar, C. Stephen Djedjos, Michael Charlton, Michael S. Middleton, Magdy Elkhashab, Manal F. Abdelmalek, Parvez S. Mantry, Anna Mae Diehl, Ren Xu, Stephen H. Caldwell, Nezam H. Afdhal, Ling Han, Reem Ghalib, Claude B. Sirlin, Kris V. Kowdley, Rohit Loomba, Eric Lawitz, Zachary Goodman, G. Mani Subramanian
Publikováno v:
Journal of hepatology, vol 70, iss 1
Jayakumar, Saumya; Middleton, Michael S; Lawitz, Eric J; Mantry, Parvez S; Caldwell, Stephen H; Arnold, Hays; et al.(2019). Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib. JOURNAL OF HEPATOLOGY, 70(1), 133-141. doi: 10.1016/j.jhep.2018.09.024. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/96b1p0vj
Jayakumar, Saumya; Middleton, Michael S; Lawitz, Eric J; Mantry, Parvez S; Caldwell, Stephen H; Arnold, Hays; et al.(2019). Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib. JOURNAL OF HEPATOLOGY, 70(1), 133-141. doi: 10.1016/j.jhep.2018.09.024. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/96b1p0vj
Background & Aims Non-invasive tools for monitoring treatment response and disease progression in non-alcoholic steatohepatitis (NASH) are needed. Our objective was to evaluate the utility of magnetic resonance (MR)-based hepatic imaging measures for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da08a6210691f138234a9000638dd431
https://escholarship.org/uc/item/96b1p0vj
https://escholarship.org/uc/item/96b1p0vj
Autor:
Tania Roskams, J Soeda, A Mouralidarane, Steven A. Thomas, Anna Mae Diehl, Marco Novelli, Jude A. Oben, Shuvra Ray
Publikováno v:
Hepatology. 60:1023-1034
Acetaminophen (APAP)-induced acute liver injury (AILI) is a major health problem. Accumulating evidence suggests that the sympathetic nervous system (SNS) regulates neuronal and hematopoietic progenitors. SNS signaling affects hepatic progenitor/oval
Publikováno v:
Mayo Clinic Proceedings. 89:120-130
Cirrhosis and liver cancer, the main causes of liver-related morbidity and mortality, result from defective repair of liver injury. This article summarizes rapidly evolving knowledge about liver myofibroblasts and progenitors, the 2 key cell types th