Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Cynthia A. Moylan, Alisha M. Mavis, Dereje Jima, Rachel Maguire, Mustafa Bashir, Jeongeun Hyun, Melanie N. Cabezas, Alice Parish, Donna Niedzwiecki, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, Cathrine Hoyo
Publikováno v:
Epigenetics, Vol 17, Iss 11, Pp 1446-1461 (2022)
Non-Alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. Epigenetic alterations, such as through DNA methylation (DNAm), may link adverse childhood exposures and fatty liver and provide non-invasive methods
Externí odkaz:
https://doaj.org/article/340dddde15ac419da0f5f9f960cb993c
Autor:
Arun J. Sanyal, Stephen A. Williams, Joel E. Lavine, Brent A. Neuschwander-Tetri, Leigh Alexander, Rachel Ostroff, Hannah Biegel, Kris V. Kowdley, Naga Chalasani, Srinivasan Dasarathy, Anna Mae Diehl, Rohit Loomba, Bilal Hameed, Cynthia Behling, David E. Kleiner, Saul J. Karpen, Jessica Williams, Yi Jia, Katherine P. Yates, James Tonascia
Publikováno v:
Journal of hepatology, vol 78, iss 4
J Hepatol
J Hepatol
There is an unmet need for development of non-invasive tests for the diagnostic assessment and monitoring of nonalcoholic fatty liver disease (NAFLD).Using modified-aptamer proteomics, we assayed 5220 proteins in each of 2852 single serum samples fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98d930021ee18e344ed6b8fc32118b5
https://escholarship.org/uc/item/0d9809np
https://escholarship.org/uc/item/0d9809np
Autor:
Anna Mae Diehl, Tianyi Chen
Publikováno v:
Hepatology
Acute liver damage causes hepatocyte stress and death, but in chronic liver disease impaired hepatocyte regeneration and immune cell infiltration prevents recovery. While the roles of both impaired liver regeneration and immune infiltration have been
Autor:
Raquel Maeso‐Díaz, George D. Dalton, Sehhoon Oh, Kuo Du, Linda Tang, Tianyi Chen, Rajesh K. Dutta, Jessica H. Hartman, Joel N. Meyer, Anna Mae Diehl
Publikováno v:
Aging Cell. 21
Older age is a major risk factor for damage to many tissues, including liver. Aging undermines resiliency and impairs liver regeneration. The mechanisms whereby aging reduces resiliency are poorly understood. Hedgehog is a signaling pathway with crit
Autor:
Fabian Heinemann, Peter Gross, Svetlana Zeveleva, Hu Sheng Qian, Jon Hill, Anne Höfer, Danny Jonigk, Anna Mae Diehl, Manal Abdelmalek, Martin C. Lenter, Steven S. Pullen, Paolo Guarnieri, Birgit Stierstorfer
Publikováno v:
Scientific reports 12, 19236 (2022). doi:10.1038/s41598-022-23905-3
Scientific reports 12, 19236 (2022). doi:10.1038/s41598-022-23905-3
Published by Macmillan Publishers Limited, part of Springer Nature, [London]
Published by Macmillan Publishers Limited, part of Springer Nature, [London]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cb9e007dff78cbfe9108624437c7d5
Autor:
Anna Mae Diehl, Ning-Ping Zhang, Ying Wang, Chen Yang, Xiuping Liu, Xue-Jing Liu, Wen‐Yue Dong, Chang Liu, Li Xie, Manal F. Abdelmalek, Jian Wu, Chenjian Gu, Kuo Du, Chen Niu
Publikováno v:
Liver Int
Background and aims Treatment of non-alcoholic steatohepatitis (NASH) is challenging, because suppressing fibrotic progression has not been achieved consistently by drug candidates currently in clinical trials. The aim of this study was to investigat
Autor:
Rajesh Kumar Dutta, Seh-Hoon Oh, Wen-Hsuan Yang, Jen-Tsan Ashley Chi, Kuo Du, Anna Mae Diehl, Tianai Sun
Publikováno v:
Liver Int
Background & aims The outcome of liver injury is dictated by factors that control the accumulation of myofibroblastic (activated) hepatic stellate cells (MF-HSCs) but therapies that specifically block this process have not been discovered. We evaluat
Autor:
Tinsay A, Woreta, Mark L, Van Natta, Mariana, Lazo, Arunkumar, Krishnan, Brent A, Neuschwander-Tetri, Rohit, Loomba, Anna, Mae Diehl, Manal F, Abdelmalek, Naga, Chalasani, Samer, Gawrieh, Srinivasan, Dasarathy, Raj, Vuppalanchi, Mohammad S, Siddiqui, Kris V, Kowdley, Arthur, McCullough, Norah A, Terrault, Cynthia, Behling, David E, Kleiner, Mark, Fishbein, Paula, Hertel, Laura A, Wilson, Emily P, Mitchell, Laura A, Miriel, Jeanne M, Clark, James, Tonascia, Arun J, Sanyal
Publikováno v:
PLOS ONE. 17:e0266859
Background and aims Management of patients with NASH who are at elevated risk of progressing to complications of cirrhosis (at-risk NASH) would be enhanced by an accurate, noninvasive diagnostic test. The new FAST™ score, a combination of FibroScan
Autor:
Anna Mae Diehl, Nezam H. Afdhal, Andrew J. Muir, Jaime Bosch, G. Mani Subramanian, Zachary Goodman, Raul Aguilar Schall, Arun J. Sanyal, Stephen A. Harrison, Stephen H. Caldwell, B. Mccolgan, Maria Stepanova, Manal F. Abdelmalek, Robert P. Myers, Vlad Ratziu, Zobair M. Younossi, Mitchell L. Shiffman
Publikováno v:
Journal of Hepatology. 69:1365-1370
Although patients with cryptogenic cirrhosis have historically been considered as having "burnt-out" non-alcoholic steatohepatitis (NASH), some controversy remains. The aim of this study was to compare outcomes of patients with cryptogenic cirrhosis
Autor:
B. Mccolgan, Eric Lawitz, Anna Mae Diehl, Catherine Jia, Manal F. Abdelmalek, Jaime Bosch, Zobair M. Younossi, G. Mani Subramanian, Mitchell L. Shiffman, John G. McHutchison, Reem Ghalib, Nezam H. Afdhal, Don C. Rockey, Andrew J. Muir, Raul Aguilar Schall, Vlad Ratziu, Zachary Goodman, Stephen H. Caldwell, Arun J. Sanyal, Stephen A. Harrison, Robert P. Myers
Publikováno v:
Gastroenterology. 155:1140-1153
Background & Aims Lysyl oxidase-like 2 contributes to fibrogenesis by catalyzing cross-linkage of collagen. We evaluated the safety and efficacy of simtuzumab, a monoclonal antibody against lysyl oxidase-like 2, in two phase 2b trials of patients wit