Zobrazeno 1 - 2
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pro vyhledávání: '"Cory Giesbrecht"'
Publikováno v:
Molecular Therapy. 15:713-720
Using a new controlled mixing process, highly transfection-competent polyplexes were formed and subsequently encapsulated within a lipid bilayer. The resulting "pre-condensed stable plasmid lipid particles" (pSPLPs) have small size (104+/-3 nm) and l
Autor:
Lloyd Jeffs, Ellen Grace Ambegia, Ian MacLachlan, Cory Giesbrecht, Lorne R. Palmer, Shannon Ewanick
Publikováno v:
Pharmaceutical Research. 22:362-372
A fully scalable and extrusion-free method was developed to prepare rapidly and reproducibly stabilized plasmid lipid particles (SPLP) for nonviral, systemic gene therapy. Liposomes encapsulating plasmid DNA were formed instantaneously by mixing lipi