Zobrazeno 1 - 10
of 36
pro vyhledávání: 'Lüllmann-Rauch, Renate'
Autor:
Hans Bockhardt, Renate Lüllmann-Rauch
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:45-48
This study was aimed at the question of whether or not the antidepressant zimelidine, which is an amphiphilic cationic compound, can induce generalized lipidosis in animals. Rats were chronically treated with high oral doses (80 mg/kg) of the drug, a
Publikováno v:
Toxicology. 110:27-37
The antimalarial agents quinacrine and chloroquine are well known as potent inducers of lysosomal storage of polar lipids (lipidosis) in cell culture and in vivo. In previous experiments on cultured fibroblasts, chloroquine was shown to additionally
Autor:
Renate Lüllmann-Rauch, Stefan H. Geist
Publikováno v:
Annals of Anatomy - Anatomischer Anzeiger. 176:3-9
Summary The purpose of this study was to investigate the effects of two lipidosis-inducing drugs (the anorectic drug chlorphentermine and the tricyclic antidepressantimipramine) upon the estrous cycle of rats and upon the morphology of the vaginal an
Publikováno v:
Xenobiotica. 20:1259-1267
1. Drug accumulation without a concomitant elevation of blood level may occur if the capacity of the tissue to bind drug increases during chronic treatment. 2. This special type of accumulation is found with cationic-amphiphilic drugs, which induce t
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Virchows Archiv B Cell Pathology Including Molecular Pathology. 44:355-368
This ultrastructural and histochemical study deals with the lysosomal storage phenomena occurring in the rat liver after repeated oral administration of tilorone, an agent with anti-tumor and anti-viral activities. In the sinusoidal endothelium and i
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 286:165-179
Lymphocytes of rat lymph nodes have previously been revealed as reliable and sensitive indicators of a particular drug side effect, notably a generalized phospholipidosis, inducible by a compound of amphiphilic character (chlorphentermine). The purpo
Autor:
Heinz Lüllmann, Renate Lüllmann-Rauch
Publikováno v:
Toxicology and Applied Pharmacology. 61:138-146
The antiestrogenic drug tamoxifen is an amphiphilic cationic compound and might therefore be suspected to interfere with intralysosomal catabolism of polar lipids as previously observed with several other amphiphilic cationic drugs. Large oral doses
Publikováno v:
Biochemical Pharmacology. 27:1103-1108
Autor:
Renate Lüllmann-Rauch
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 283:219-222
Prolonged treatment of rats with high doses of the tricyclic antidepressants iprindole, clomipramine, or 1-chlor-amitriptyline induced the formation of lamellated and crystalloid cytoplasmic inclusion bodies within dorsal root ganglion cells. The ult
Publikováno v:
Toxicology. 44:45-59
The purpose of this study was to test whether or not the antiviral drug amantadine induces the structural features of lipidosis in intact animals (rats) and cultured cells, and to investigate the interactions between amantadine and phospholipids. Chl