Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Kazuo Achiwa"'
Publikováno v:
Synthetic Communications. 35:857-865
Racemic trans‐2,3‐di[(3,4‐methylenedioxy)benzyl]‐1,4‐butanediol (dihydrocubebin) 6 was enantioselectively esterified using lipases as catalysts with vinyl acetate. Optically active (S,S)‐1,4‐butanediol 6 obtained was selectively oxygena
Autor:
Hirose Yoshihiko, Yoshiyasu Terao, Yukiyoshi Yamazaki, K. Maruyama, Hirosato Ebiike, Y. Kurono, Kazuo Achiwa, I. Sasaki, Kariya Kinya
Publikováno v:
Chemical and Pharmaceutical Bulletin. 45:863-868
Chiral 4-aryl-1, 4-dihydro-2, 6-dimethyl-3, 5-pyridinedicarboxylates and 1, 4-dihydro-2, 4, 6-trimethyl-3, 5-pyridinedicarboxylate have been obtained in 80-99%ee by lipase-catalyzed hydrolysis of bis(acyloxymethyl) 1, 4-dihydro-3, 5-pyridinedicarboxy
Inversion of enantioselectivity in hydrolysis of 1,4-dihydropyridines by point mutation of lipase PS
Publikováno v:
Tetrahedron Letters. 36:1063-1066
Mutant of lipase PS replaced three amino acids by site-specific mutagenesis first showed the inversion of enantioselectivity and the solvent effect in hydrolysis of 1,4-dihydropyridines.
Autor:
Hirosato Ebiike, Kazuo Achiwa
Publikováno v:
Tetrahedron: Asymmetry. 5:1447-1450
Homochiral ( R )-nilvadipine was synthesized from a prochiral substrate using lipase-catalyzed asymmetric hydrolysis and subsequent regioselective bromination as key steps.
Publikováno v:
Tetrahedron: Asymmetry. 5:1407-1410
Chiral non-racemic 5,5-disubstituted hydantoins were prepared by lipase-catalyzed enantioselective hydrolyses of their N -acyloxymethyl groups or esterification of their N -hydroxymethyl groups.
Publikováno v:
Journal of Synthetic Organic Chemistry, Japan. 52:638-648
The synthetic method of optically active compound by using lipase-catalysis in organic solvent has been generally accepted recently. Because lipases possess especially broad substrate specificity and are commercially available. However, efficient sub
Autor:
Kazuo Achiwa, Eisaku Mizuguchi
Publikováno v:
Tetrahedron: Asymmetry. 4:2303-2306
The d-α-tocopherol was synthesized effectively by enzyme-catalyzed enantioselective hydrolysis of dl-α-tocopherol oxalate. The enzymes can recognize a stereogenic carbon atom remote from the reaction site.
Publikováno v:
ChemInform. 22
The asymmetric synthesis of chiral cis-endo-5-norbornene-2, 3-dimethanol mono acetate by lipase-catalyzed transesterification, and it was used to synthesize an optically active TXA2 antagonist.
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 23
New strategy of lipase-catalyzed asymmetric reactions is described. Chiral 2-O-substituted glycerols, 2-substituted 1, 3-propanediols and 1, 4-diols were obtained in high optical yields by the asymmetric transesterification using activated esters as