Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Louis C. Tan"'
Autor:
Wing Lok Au, Louis C. Tan, Kumar M. Prakash, Y.-Y. Ng, Jianjun Liu, H.-K. Kwok, Yi Zhao, Tatsushi Toda, Eng-King Tan, R. Pavanni, Wataru Satake, W.-T. Zhao
Publikováno v:
Neurology. 75:508-512
Objective: A genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD) susceptibility loci on 1q32 (PARK16) (OMIM 613164) and BST1. We analyzed single nucleotide polymorphism (SNPs) located at the GWAS-li
The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence
Autor:
L. Sun, R. Pavanni, Eng-King Tan, Chin Song Lu, Jianjun Liu, Prasanna R. Kolatkar, Lisa Skipper, Yih Yuen, E. Chua, Vincenzo Bonifati, Yi Zhao, Meng-Cheong Wong, M. G. Tan, S. Tang, Louis C. Tan, Stephanie Fook-Chong, A. Di Fonzo
Publikováno v:
Human Genetics, 120(6), 857-863. Springer-Verlag
Evidence of LRRK2 haplotypes associated with Parkinson's disease (PD) risk was recently found in the Chinese population from Singapore, and a common LRRK2 missense variant, Gly2385Arg, was independently detected as a putative risk factor for PD in th
Autor:
Jia Nee, Foo, Sun Ju, Chung, Louis C, Tan, Herty, Liany, Ho-Sung, Ryu, Myunghee, Hong, Tat Hung, Koh, Ishak D, Irwan, Wing-Lok, Au, Kumar-M, Prakash, Tin, Aung, Ching-Yu, Cheng, Siow-Ann, Chong, Chiea Chuen, Khor, Jimmy, Lee, E-Shyong, Tai, Eranga N, Vithana, Tien-Yin, Wong, Kyuyoung, Song, Jianjun, Liu, Eng-King, Tan
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 31(4)
Genome-wide association studies have identified several loci associated with Parkinson's disease (PD). Whole-exome sequencing detects rare coding variants, but their links with PD genome-wide association study loci are unknown. Our objective was to i
Autor:
Yi Zhao, Yi-Chun Chen, Chiung Mei Chen, Yih Ru Wu, Kumar M. Prakash, Wing Lok Au, Guey Jen Lee-Chen, Zhong Pei, Eng-King Tan, Jin Sheng Zeng, Ling Chen, Yifan Zheng, X. Fu, Louis C. Tan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e36123 (2012)
PLoS ONE, Vol 7, Iss 7, p e36123 (2012)
It has been suggested that a common LRRK2 polymorphic variant (A419V (rs34594498 C >T)) may be a risk factor among Asians (especially in Taiwan). In this study, we examined this variant in a larger and independent Taiwan cohort. We found the frequenc
Autor:
Yi Zhao, R. Pavanni, R. Li, Hui-Qin Lim, Kumar M. Prakash, Louis C. Tan, Michelle Tang, Eng-King Tan, Stephanie Fook-Chong, Yuen Yih
Publikováno v:
Human Genetics. 124:287-288
We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson’s disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1–5.6). In the multivariate logistic regression (with adjustments made fo