Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Charlotte E. Lee"'
Autor:
Carlos M. Castorena, Joel K. Elmquist, Newaz Ahmed, Caleb C. Lord, Heather M Dungan Lemko, William L. Holland, Alexandre Caron, Syann Lee, Teppei Fujikawa, Chen Liu, Charlotte E. Lee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee2f33bdb774c5c94cb2c26f278f9f72
https://doi.org/10.7554/elife.33710.014
https://doi.org/10.7554/elife.33710.014
Autor:
Carlos M. Castorena, Heather M Dungan Lemko, Alexandre Caron, Syann Lee, Newaz Ahmed, Chen Liu, Charlotte E. Lee, Caleb C. Lord, Joel K. Elmquist, William L. Holland, Teppei Fujikawa
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that leptin’s actions are mediated through pro-opiomelanocortin (POMC) neurons that express lepti
Publikováno v:
Journal of Clinical Investigation. 121:2413-2421
Leptin is an adipose-derived hormone that signals to inform the brain of nutrient status; loss of leptin signaling results in marked hyperphagia and obesity. Recent work has identified several groups of neurons that contribute to the effects of lepti
Autor:
Kevin W. Williams, Carol F. Elias, Joel K. Elmquist, Syann Lee, Charlotte E. Lee, Michelle J. Choi, Michael Scott, Lisandra O. Margatho
Publikováno v:
The Journal of Neuroscience. 30:2472-2479
Acute leptin administration results in a depolarization and concomitant increase in the firing rate of a subpopulation of arcuate proopiomelanocortin (POMC) cells. This rapid activation of POMC cells has been implicated as a cellular correlate of lep
Autor:
Joel K. Elmquist, Jennifer Lachey, Scott M. Sternson, Charlotte E. Lee, Carol F. Elias, Michael Scott, Jeffrey M. Friedman
Publikováno v:
The Journal of Comparative Neurology. 514:518-532
The central actions of leptin are essential for homeostatic control of adipose tissue mass, glucose metabolism, and many autonomic and neuroendocrine systems. In the brain, leptin acts on numerous different cell types via the long-form leptin recepto
Autor:
Charlotte E. Lee, Silvia Lacchini, Jose Donato, Carol F. Elias, Luciane V. Sita, Celso Rodrigues Franci, Newton S. Canteras, Renata Juliana da Silva, Syann Lee, Jackson C. Bittencourt
Publikováno v:
The Journal of Neuroscience. 29:5240-5250
Physiological conditions of low leptin levels like those observed during negative energy balance are usually characterized by the suppression of luteinizing hormone (LH) secretion and fertility. Leptin administration restores LH levels and reproducti
Autor:
Roberto Coppari, Jane K. Howard, Paul Kievit, Jeffrey S. Flier, Nina Balthasar, Michael K. Badman, Charlotte E. Lee, Akihiko Yoshimura, Hiroyuki Mori, Joel K. Elmquist
Publikováno v:
Cell Metabolism. 4(2):123-132
SummarySuppressor of cytokine signaling-3 (Socs-3) negatively regulates the action of various cytokines, as well as the metabolic hormones leptin and insulin. Mice with haploinsufficiency of Socs-3, or those with neuronal deletion of Socs-3, are lean
Autor:
Joel K. Elmquist, Robert A. McGovern, Shun M. Liu, Roberto Coppari, Abigail E. Pullen, Streamson C. Chua, Charlotte E. Lee, Bradford B. Lowell, Thomas Ludwig, Masumi Ichinose, Christopher D. Kenny, Vinsee Tang
Publikováno v:
Cell Metabolism. 1:63-72
SummaryLeptin is required for normal energy and glucose homeostasis. The hypothalamic arcuate nucleus (ARH) has been proposed as an important site of leptin action. To assess the physiological significance of leptin signaling in the ARH, we used mice
Autor:
Nina Balthasar, Bradford B. Lowell, Christopher D. Kenny, Charlotte E. Lee, Roberto Coppari, Robert A. McGovern, Joel K. Elmquist, Streamson C. Chua, Julie E. McMinn, Shun M. Liu, Vinsee Tang
Publikováno v:
Neuron. 42:983-991
Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of leptin signaling in these neurons has not yet been directly tested. Here
Autor:
Charlotte E. Lee, Joseph Kelly, Rexford S. Ahima, Daniel J. Drucker, Clifford B. Saper, Joel K. Elmquist, Carol F. Elias
Publikováno v:
The Journal of Comparative Neurology. 423:261-281
Leptin has profound effects on food intake, body weight, and neuroendocrine status. The lack of leptin results in hormonal and metabolic alterations and a dramatic increase in body weight. Leptin acts in the brain, especially in the hypothalamus; how