Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Charlotte E. Lee"'
Autor:
Rebecca Berdeaux, Joel K. Elmquist, Natalie J. Michael, Ryan P. Reynolds, Carlos M. Castorena, Alexandre Caron, Philipp E. Scherer, Syann Lee, Charlotte E. Lee
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 27, Iss, Pp 11-21 (2019)
Molecular Metabolism, Vol 27, Iss, Pp 11-21 (2019)
Objective The sympathetic nervous system (SNS) is a key regulator of the metabolic and endocrine functions of adipose tissue. Increased SNS outflow promotes fat mobilization, stimulates non-shivering thermogenesis, promotes browning, and inhibits lep
Autor:
Jose Donato, Charlotte E. Lee, Ki Woo Kim, Syann Lee, Carol F. Elias, Dong Min Shin, Yun Hee Choi, Dong Joo Yang, Teppei Fujikawa, Daisuke Kohno
Publikováno v:
Experimental & Molecular Medicine
Experimental and Molecular Medicine, Vol 51, Iss 4, Pp 1-9 (2019)
Experimental and Molecular Medicine, Vol 51, Iss 4, Pp 1-9 (2019)
Phosphoinositide 3-kinase (PI3K) signaling in hypothalamic neurons integrates peripheral metabolic cues, including leptin and insulin, to coordinate systemic glucose and energy homeostasis. PI3K is composed of different subunits, each of which has se
Autor:
Tiemin Liu, Philipp E. Scherer, Ningyan Zhang, Christine M. Kusminski, Alexandre Caron, Na Li, Hui Deng, Kai Sun, Jia Sun, Zhuzhen Zhang, Zhenyan He, Yingfeng Deng, Robbie D. Schultz, Kevin W. Williams, Angela K. Odle, Charlotte E. Lee, Gwen V. Childs, Joel K. Elmquist, Min Kim, Ruth Gordillo, Shangang Zhao, Yi Zhu, Qingzhang Zhu, Zhiqiang An, Wei Xiong
Publikováno v:
Cell Metab
The physiological role of leptin is thought to be a driving force to reduce food intake and increase energy expenditure. However, leptin therapies in the clinic have failed to effectively treat obesity, predominantly due to a phenomenon referred to a
Autor:
Carlos M. Castorena, Joel K. Elmquist, Newaz Ahmed, Caleb C. Lord, Heather M Dungan Lemko, William L. Holland, Alexandre Caron, Syann Lee, Teppei Fujikawa, Chen Liu, Charlotte E. Lee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee2f33bdb774c5c94cb2c26f278f9f72
https://doi.org/10.7554/elife.33710.014
https://doi.org/10.7554/elife.33710.014
Autor:
Carlos M. Castorena, Heather M Dungan Lemko, Alexandre Caron, Syann Lee, Newaz Ahmed, Chen Liu, Charlotte E. Lee, Caleb C. Lord, Joel K. Elmquist, William L. Holland, Teppei Fujikawa
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that leptin’s actions are mediated through pro-opiomelanocortin (POMC) neurons that express lepti
Publikováno v:
Journal of Clinical Investigation. 121:2413-2421
Leptin is an adipose-derived hormone that signals to inform the brain of nutrient status; loss of leptin signaling results in marked hyperphagia and obesity. Recent work has identified several groups of neurons that contribute to the effects of lepti
Autor:
Ki Woo Kim, Jeffrey M. Zigman, Jennifer W. Hill, Laurent Gautron, Danielle A. Lauzon, Joel K. Elmquist, Charlotte E. Lee, Michelle J. Choi, Jean J. Zhao, Bradford B. Lowell, Jong Woo Sohn, Makoto Fukuda, Yong Xu, Harveen Dhillon
Publikováno v:
Cell Metabolism. 12(1):88-95
SummaryPhosphatidyl inositol 3-kinase (PI3K) signaling in the hypothalamus has been implicated in the regulation of energy homeostasis, but the critical brain sites where this intracellular signal integrates various metabolic cues to regulate food in
Autor:
Kevin W. Williams, Carol F. Elias, Joel K. Elmquist, Syann Lee, Charlotte E. Lee, Michelle J. Choi, Michael Scott, Lisandra O. Margatho
Publikováno v:
The Journal of Neuroscience. 30:2472-2479
Acute leptin administration results in a depolarization and concomitant increase in the firing rate of a subpopulation of arcuate proopiomelanocortin (POMC) cells. This rapid activation of POMC cells has been implicated as a cellular correlate of lep
Autor:
Joel K. Elmquist, Jennifer Lachey, Scott M. Sternson, Charlotte E. Lee, Carol F. Elias, Michael Scott, Jeffrey M. Friedman
Publikováno v:
The Journal of Comparative Neurology. 514:518-532
The central actions of leptin are essential for homeostatic control of adipose tissue mass, glucose metabolism, and many autonomic and neuroendocrine systems. In the brain, leptin acts on numerous different cell types via the long-form leptin recepto
Autor:
Charlotte E. Lee, Silvia Lacchini, Jose Donato, Carol F. Elias, Luciane V. Sita, Celso Rodrigues Franci, Newton S. Canteras, Renata Juliana da Silva, Syann Lee, Jackson C. Bittencourt
Publikováno v:
The Journal of Neuroscience. 29:5240-5250
Physiological conditions of low leptin levels like those observed during negative energy balance are usually characterized by the suppression of luteinizing hormone (LH) secretion and fertility. Leptin administration restores LH levels and reproducti