Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Muriel Paul"'
Publikováno v:
International Journal for Parasitology. 27:1361-1367
The use of drug delivery systems may reduce the toxicity and improve the activity of antileishmanial compounds. In view of such a strategy, we loaded the antileishmanial agent pentamidine on polymethacrylate nanoparticles. The activity of pentamidine
Publikováno v:
Parasite (Paris, France). 4(4)
The activity of pentamidine-loaded poly(D,L-lactide) nanoparticles was compared, by determination of median effective doses (ED50), to that of free pentamidine in a murine model of visceral leishmaniasis induced by Leishmania infantum. BALB/c mice we
Autor:
Alain Astier, T. Fusai, Rémy Durand, Muriel Paul, D Rivollet, Y. Boulard, R. Houin, M. Deniau, Christian Bories
Publikováno v:
Parasite (Paris, France). 4(2)
Drug targeting enhances drug efficacy. This principle was tested in the treatment of an experimental visceral leishmaniasis. Using transmission electron microscopy (TEM) we localized pentamidine-loaded polymethacrylate nanoparticles in the liver of m
Autor:
Christian Bories, Muriel Paul, R. Houin, D Rivollet, Alain Astier, Rémy Durand, M. Deniau, T. Fusai
Publikováno v:
Parasite (Paris, France). 1(4)
The efficiency of antileishmanial agents may be enhanced by improving their bioavailability with a colloidal drug carrier. We have investigated the action of free pentamidine, compared with pentamidine bound to polymethacrylate nanoparticles, in a ro