Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Udaiyappan Janakiraman"'
Autor:
Mark A. Nelson, Kohji Fukunaga, Udaiyappan Janakiraman, Chinnasamy Dhanalakshmi, Aubin Moutal, Lisa Boinon, Jie Yu, Rajesh Khanna
Publikováno v:
Neurobiology of Disease, Vol 143, Iss, Pp 105006-(2020)
Neurobiol Dis
Neurobiol Dis
T-type calcium channels, in the central nervous system, are involved in the pathogenesis of many neurodegenerative diseases, including TAF1 intellectual disability syndrome (TAF1 ID syndrome). Here, we evaluated the efficacy of a novel T-type Ca2+ ch
Autor:
Chinnasamy Dhanalakshmi, Udaiyappan Janakiraman, Mark A. Nelson, Aubin Moutal, Rajesh Khanna, Kohji Fukunaga
Publikováno v:
Neurobiology of disease
Neurobiology of Disease, Vol 149, Iss, Pp 105224-(2021)
Neurobiology of Disease, Vol 149, Iss, Pp 105224-(2021)
The TATA-box binding protein associated factor 1 (TAF1) is part of the TFIID complex that plays a key role during the initiation of transcription. Variants of TAF1 are associated with neurodevelopmental disorders. Previously, we found that CRISPR/Cas
Autor:
Shelby N. Batchelor, Mark A. Nelson, Udaiyappan Janakiraman, Annaduri Anandhan, Lisa Boinon, Jie Yu, Aubin Moutal, Rajesh Khanna, Dhanalakshmi Chinnasamy
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 132, Iss, Pp-(2019)
Neurobiology of Disease, Vol 132, Iss, Pp-(2019)
TAF1/MRSX33 intellectual disability syndrome is an X-linked disorder caused by loss-of-function mutations in the TAF1 gene. How these mutations cause dysmorphology, hypotonia, intellectual and motor defects is unknown. Mouse models which have embryon