Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ajit Jadhav"'
Autor:
Anju Singh, Nicolas Acquavella, Juan J. Marugan, Suman K. Vodnala, Myagmarjav Dashnyam, Chyi-Chia Richard Lee, Noel Southall, Marc Ferrer, Nicholas P. Restifo, Christopher R. Dextras, Zhiya Yu, Lesley A. Mathews Griner, Bryan Chim, Janani Sundaresan, Ajit Jadhav, Xin Hu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Small molecule based targeted therapies for the treatment of metastatic melanoma hold promise but responses are often not durable, and tumors frequently relapse. Response to adoptive cell transfer (ACT)-based immunotherapy in melanoma patients are du
Autor:
Myagmarjav Dashnyam, Stefan A. Muljo, Juan J. Marugan, Bryan Chim, Camille A. Spinner, Marc Ferrer, Andrés E. Dulcey, Prasanthi P. Koganti, Anju Singh, Vimal Selvaraj, Noel Southall, Vanja Lazarevic, Kelli M. Wilson, Ajit Jadhav, Xin Hu, Thelma M. Escobar, Xin Xu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Th17 cells are critical drivers of autoimmune diseases and immunopathology. There is an unmet need to develop therapies targeting pathogenic Th17 cells for the treatment of autoimmune disorders. Here, we report that anxiolytic FGIN-1-27 inhibits diff
Autor:
Diane L. Carlisle, Robert M. Friedlander, Anton Simeonov, Hongchun Li, Murat Can Cobanoglu, Fen Pei, Mark J. Henderson, Andrew M. Stern, Tongying Shun, Timothy R. Lezon, Seyed H Mousavi, D. Lansing Taylor, Steve Titus, Lee Apostle Mcdermott, Michael Fioravanti, Prema Iyer, Mark E. Schurdak, Ivet Bahar, Ajit Jadhav
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports
Scientific Reports
Quantitative Systems Pharmacology (QSP) is a drug discovery approach that integrates computational and experimental methods in an iterative way to gain a comprehensive, unbiased understanding of disease processes to inform effective therapeutic strat
Autor:
Darren P. Wallace, Ajit Jadhav, Robert H. Weiss, Anton Simeonov, Ty C. Voss, Yuchi Chen, Alexey Zahkarov, Josephine F. Trott, Natalia J. Martinez, Carina Danchik, Rosita R. Asawa
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited monogenic disorders, characterized by a progressive decline in kidney function due in part to the formation of fluid-filled cysts. While there is one FDA-approve
Autor:
Anton Simeonov, Steve Titus, Rajan Pragani, Hongchao Zheng, Andrew L. McIver, Surendra Karavadhi, Olivia W. Lee, Ajit Jadhav, Kyle R. Brimacombe, Amy Wang, Xin Xu, Dorian M. Cheff, Mark J. Henderson, Pranav Shah, Tobie D. Lee, Natalia J. Martinez, Min Shen, Matthew D. Hall, Yuhong Fang, Jason M. Rohde, Matthew B. Boxer, Daniel J. Urban, Xiaodong Wang, Mindy I. Davis, Li Liu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that are mutated in a variety of cancers to confer a gain-of-function activity resulting in the accumulation and secretion of an oncometabolite, D-2-hydroxyglutarate (2-HG). A
Autor:
Natalia J. Martinez, Ganesha Rai, Adam Yasgar, Wendy A. Lea, Hongmao Sun, Yuhong Wang, Diane K. Luci, Shyh-Ming Yang, Kana Nishihara, Shunichi Takeda, null Mohiuddin, Irina Earnshaw, Tetsuya Okada, Kazutoshi Mori, Kelli Wilson, Gregory J. Riggins, Menghang Xia, Maurizio Grimaldi, Ajit Jadhav, David J. Maloney, Anton Simeonov
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166506 (2016)
PLoS ONE
PLoS ONE
The endoplasmic reticulum (ER) is involved in Ca2+ signaling and protein folding. ER Ca2+ depletion and accumulation of unfolded proteins activate the molecular chaperone GRP78 (glucose-regulated protein 78) which in turn triggers the ER stress respo
Autor:
Adam Yasgar, Steven A. Titus, Yuhong Wang, Carina Danchik, Shyh-Ming Yang, Vasilis Vasiliou, Ajit Jadhav, David J. Maloney, Anton Simeonov, Natalia J. Martinez
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0197292 (2018)
PLoS ONE, Vol 13, Iss 5, p e0197292 (2018)
Aldehyde dehydrogenase enzymes (ALDHs) have a broad spectrum of biological activities through the oxidation of both endogenous and exogenous aldehydes. Increased expression of ALDH1A1 has been identified in a wide-range of human cancer stem cells and
Autor:
Francis S. Willard, Steven A. Heidler, Jonathan A. Lee, G. Sitta Sittampalam, Robert B. Peery, Ajit Jadhav, Saba Husain, Sarah E. Oliver, Jeremy J. Yang, Noel Southall, Shaoyou Chu, Thomas S. Dexheimer, David J. Wild, Paul Shinn, Christopher P. Austin, Craig J. Thomas, Natalie Franklin, Jennifer Oler, Anton Simeonov, Jeffrey K. Smallwood, Susan Jaken, Ruili Huang, Rajarshi Guha, Karen Cox, Jeffrey J. Sutherland
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0130796 (2015)
PLoS ONE
PLoS ONE
Phenotypic assays have a proven track record for generating leads that become first-in-class therapies. Whole cell assays that inform on a phenotype or mechanism also possess great potential in drug repositioning studies by illuminating new activitie
Autor:
Adam Yasgar, Steve Titus, Anton Simeonov, Carina Danchik, Ajit Jadhav, Vasilis Vasiliou, David J. Maloney, Natalia J. Martinez, Shyh Ming Yang, Yuhong Wang
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170937 (2017)
PLoS ONE
PLoS ONE
Aldehyde dehydrogenase enzymes (ALDHs) have a broad spectrum of biological activities through the oxidation of both endogenous and exogenous aldehydes. Increased expression of ALDH1A1 has been identified in a wide-range of human cancer stem cells and
Autor:
Auric Kantz, Matthew P. Jacobson, David J. Maloney, Chakrapani Kalyanaraman, J. Brian Jameson, Theodore R. Holman, Lena Schultz, Ajit Jadhav, Anton Simeonov
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 8, p e104094 (2014)
PLoS ONE, Vol 9, Iss 8, p e104094 (2014)
Lipoxygenase (LOX) enzymes catalyze the hydroperoxidation of arachidonic acid and other polyunsaturated fatty acids to hydroxyeicosatetraenoic acids with varying positional specificity to yield important biological signaling molecules. Human epitheli