Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Martin J. Landray"'
Autor:
M Mafham, Guilherme Pessoa-Amorim, Mark Campbell, Richard Haynes, Peter Horby, Lucy Fletcher, Martin J Landray
Publikováno v:
Future Healthc J
When COVID-19 hit the UK in early 2020, there were no known treatments for a condition that results in the death of around one in four patients hospitalised with this disease. Around the world, possible treatments were administered to huge numbers of
Autor:
Wei Shen Lim, John C. Marshall, Viviane C Veiga, Bin Du, Jonathan Emberson, Judit Villar, Marie Leclerc, Azevedo Lcp., Otavio Berwanger, Flávia Ribeiro Machado, Derek C. Angus, Bruno Giraudeau, Richard Haynes, A. Le Gouge, Arthur S. Slutsky, Dequin P-F., Peter Horby, Srinivas Murthy, Cameron Green, Morten Hylander Møller, Janet V. Diaz, Anders Granholm, Higgins Jpt., Martin J Landray, Steven A R Webb, N Heming, Jelena Savović, Anthony C. Gordon, Sterne Jac., Peter Jüni, Bruno Martins Tomazini, Ferhat Meziani, Alexandre Biasi Cavalcanti, Colin McArthur, M W Petersen, Anders Perner, David Fisher, Djillali Annane
Publikováno v:
Sterne, J A C, Murthy, S, Diaz, J, Slutsky, A S, Villar, J, Angus, D C, Annane, D, Azevedo, L C P, Berwanger, O, B Cavalcanti, A, Dequin, P-F, Du, B, Emberson, J R, Fisher, D, Giraudeau, B, Gordon, A C, Granholm, A, Green, C, Haynes, R, Heming, N, Higgins, J P T, Horby, P, Juni, P, Landray, M J, Le Gouge, A, Leclerc, M, Lim, W S, R Machado, F, McArthur, C, Meziani, F, Møller, M H, Perner, A, Petersen, M W, Savović, J, Tomazini, B, C Veiga, V, Webb, S & C Marshall, J 2020, ' Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 : A Meta-analysis ', JAMA-Journal of the American Medical Association, vol. 324, no. 13, pp. 1330-1341 . https://doi.org/10.1001/jama.2020.17023
JAMA
JAMA
IMPORTANCE: Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory
Autor:
John Williams, Jonathan Underwood, Joel Tarning, Louise Linsell, Peter Horby, Kathy Rowan, Alan A Montgomery, Natalie Staplin, A Whitehouse, Wei Shen Lim, Saul N. Faust, Katie Jeffery, Richard Haynes, J K Baillie, Edmund Juszczak, B Prudon, E Elmahi, Martin J Landray, Jonathan Emberson, Jennifer L Bell, Thomas Jaki, M Mafham, Andrew Ustianowski, Nicholas J. White, Timothy Felton, Lucy C Chappell, Martin Wiselka, J Faccenda, James A Watson
BackgroundHydroxychloroquine and chloroquine have been proposed as treatments for coronavirus disease 2019 (COVID-19) on the basis of in vitro activity, uncontrolled data, and small randomized studies.MethodsThe Randomised Evaluation of COVID-19 ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b379a1a360b1743e6843564832c3df0c
https://doi.org/10.1101/2020.07.15.20151852
https://doi.org/10.1101/2020.07.15.20151852
Publikováno v:
The New England journal of medicine. 382(7)
The Magic of Randomization Nonrandomized observational analyses have been promoted as alternatives to randomized clinical trials. However, randomization ensures balance between groups, whereas nonr...
Autor:
Jonathan A. C. Sterne, Janet Diaz, Jesús Villar, Srinivas Murthy, Arthur S. Slutsky, Anders Perner, Peter Jüni, Derek C. Angus, Djillali Annane, Luciano Cesar Pontes Azevedo, Bin Du, Pierre-Francois Dequin, Anthony C. Gordon, Cameron Green, Julian P. T. Higgins, Peter Horby, Martin J. Landray, Giuseppe Lapadula, Amelie Le Gouge, Marie Leclerc, Jelena Savović, Bruno Tomazini, Balasubramanian Venkatesh, Steve Webb, John C. Marshall, for the WHO COVID-19 Clinical Management and Characterization Working Group
Publikováno v:
Trials
Trials, BioMed Central, 2020, 21 (1), ⟨10.1186/s13063-020-04641-3⟩
Sterne, J A C, Diaz, J, Villar, J, Murthy, S, Slutsky, A S, Perner, A, Jüni, P, Angus, D C, Annane, D, Azevedo, L C P, Du, B, Dequin, P-F, Gordon, A C, Green, C, Higgins, J P T, Horby, P, Landray, M J, Lapadula, G, Le Gouge, A, Leclerc, M, Savović, J, Tomazini, B, Venkatesh, B, Webb, S, Marshall, J C & WHO COVID-19 Clinical Management and Characterization Working Group 2020, ' Corticosteroid therapy for critically ill patients with COVID-19 : A structured summary of a study protocol for a prospective meta-analysis of randomized trials ', Trials, vol. 21, 734 . https://doi.org/10.1186/s13063-020-04641-3
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Trials, BioMed Central, 2020, 21 (1), ⟨10.1186/s13063-020-04641-3⟩
Sterne, J A C, Diaz, J, Villar, J, Murthy, S, Slutsky, A S, Perner, A, Jüni, P, Angus, D C, Annane, D, Azevedo, L C P, Du, B, Dequin, P-F, Gordon, A C, Green, C, Higgins, J P T, Horby, P, Landray, M J, Lapadula, G, Le Gouge, A, Leclerc, M, Savović, J, Tomazini, B, Venkatesh, B, Webb, S, Marshall, J C & WHO COVID-19 Clinical Management and Characterization Working Group 2020, ' Corticosteroid therapy for critically ill patients with COVID-19 : A structured summary of a study protocol for a prospective meta-analysis of randomized trials ', Trials, vol. 21, 734 . https://doi.org/10.1186/s13063-020-04641-3
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Objectives Primary objective: To estimate the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization. Secondary objectives: To examine whether the effect of corticosteroids compared with usual car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece0c11ebfa9d66cafe122f51ee373b9
https://hal.archives-ouvertes.fr/hal-02938397
https://hal.archives-ouvertes.fr/hal-02938397
Autor:
Peter J. Friend, Natalie Staplin, Jonathan Emberson, Parminder K. Judge, Richard Haynes, Benjamin C. Storey, William G. Herrington, Lisa Blackwell, Paul N. Harden, Martin J Landray, Colin Baigent
Publikováno v:
American Journal of Transplantation. 18:1424-1434
Calcineurin inhibitors (CNIs, eg, tacrolimus) reduce short‐term kidney transplant failure, but chronic nephrotoxicity may contribute to late transplant loss. Elective conversion to inhibitors of the mammalian target of rapamycin (mTOR, eg, sirolimu
Autor:
Robert O. Blaustein, Louise Bowman, Jemma C. Hopewell, Marc S. Sabatine, Rory Collins, Maysson Al-Haj Ibrahim, Martin J Landray, Hps, Peter M. Shaw, Michael Hill, Eugene Braunwald
Publikováno v:
Circulation
Supplemental Digital Content is available in the text.
Background: Exploratory analyses of previous randomized trials generated a hypothesis that the clinical response to cholesteryl ester transfer protein (CETP) inhibitor therapy differs by ADC
Background: Exploratory analyses of previous randomized trials generated a hypothesis that the clinical response to cholesteryl ester transfer protein (CETP) inhibitor therapy differs by ADC
Autor:
Marc A. Pfeffer, Wolfgang C. Winkelmayer, Kirsten L. Johansen, Fiona Loud, Katherine R. Tuttle, Faiez Zannad, Angela Yee-Moon Wang, Ikechi G. Okpechi, Richard K. Haynes, Dugan W. Maddux, Fergus Caskey, John J.V. McMurray, Garabed Eknoyan, Ali K. Abu-Alfa, Masaomi Nangaku, Adeera Levin, Patrick Rossignol, S. Mariz, Geoffrey A. Block, Barbara S. Gillespie, Allison Tong, Vlado Perkovic, Tom Greene, Colin Baigent, John S. Gill, Romaldas Maciulaitis, David C. Wheeler, Alfred K. Cheung, Peter Rossing, Franz Schaefer, Laura M. Dember, Joseph V. Nally, Michael V. Rocco, William G. Herrington, Charmaine E. Lok, Meg Jardine, Robert D. Toto, Hiddo J.L. Heerspink, Martin Lefkowitz, Marcello Tonelli, Michael Mauer, Francesca Tentori, Martin J Landray, Josef Coresh, Michael Walsh, Christoph Wanner, Thomas F. Hiemstra, Brian J.G. Pereira, Jonathan C. Craig, Aliza Thompson, Magdalena Madero, Patrick S. Parfrey, Franklin W. Maddux, Brenda R. Hemmelgarn, Lesley A. Inker, Vivekanand Jha, Thorsten Vetter, Reshma Kewalramani, Lixin Jiang, Roberto Pecoits-Filho, Charles A. Herzog, Patrick Archdeacon, Bruce A. Cooper, David Harris, Ron T. Gansevoort
Publikováno v:
Baigent, C, Herrington, W G, Coresh, J, Landray, M J, Levin, A, Perkovic, V, Pfeffer, M A, Rossing, P, Walsh, M, Wanner, C, Wheeler, D C, Winkelmayer, W C, McMurray, J J V, KDIGO Controversies Conference on Challenges in the Conduct of Clinical Trials in Nephrology Conference Participants, Abu-Alfa, A, Archdeacon, P, Block, G A, Caskey, F J, Cheung, A K, Cooper, B, Craig, J C, Dember, L M, Eknoyan, G, Gansevoort, R T, Gill, J S, Gillespie, B, Greene, T, Harris, D C, Haynes, R, Hemmelgarn, B R, Herzog, C A, Hiemstra, T F, Inker, L A, Jardine, M J, Jha, V, Jiang, L, Johansen, K L, Kewalramani, R, Lambers Heerspink, H J, Lefkowitz, M, Lok, C E, Loud, F, Mačiulaitis, R, Maddux, D W, Maddux, F W, Madero, M, Mariz, S, Mauer, M, Nally, J V, Nangaku, M & Okpechi, I G 2017, ' Challenges in conducting clinical trials in nephrology : conclusions from a Kidney Disease—Improving Global Outcomes (KDIGO) Controversies Conference ', Kidney International, vol. 92, no. 2, pp. 297-305 . https://doi.org/10.1016/j.kint.2017.04.019
Despite the high costs of treatment of people with kidney disease and associated comorbid conditions, the amount of reliable information available to guide the care of such patients is very limited. Some treatments have been assessed in randomized tr
Autor:
William G. Herrington, Charles R.V. Tomson, Paul Cockwell, Paul Roderick, Martin J Landray, John J.V. McMurray, Colin Baigent, R. Dayanandan, Carol Knott, Alex Baxter, Jonathan Emberson, Ben Storey, Michael Hill, Richard Haynes, Philip A. Kalra, Nigel J. Brunskill, Angelyn Bethel, David C. Wheeler, Maarten W. Taal, Keith Wheatley, Kevin T. Murphy, Louise Bowman, Parminder K. Judge, Natalie Staplin
Publikováno v:
Nephrology Dialysis Transplantation
BACKGROUND:\ud Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natr
This paper reviews the role of beta-blockers in the prevention of cardiovascular morbidity and mortality in patients with diabetes mellitus. There is good evidence from randomized controlled trials that beta-blockers, in particular the lipophilic age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e4cfef84fad69fda84b13a1308253f
https://ora.ox.ac.uk/objects/uuid:e06961bf-3a28-41f3-914b-f9f707a963d9
https://ora.ox.ac.uk/objects/uuid:e06961bf-3a28-41f3-914b-f9f707a963d9