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pro vyhledávání: '"Praveen Kumar, Allu"'
Publikováno v:
Molecular Cell. 82:1976-1978
Structures of the reconstituted human inner kinetochore complex by Pesenti et al. (2022) and Yatskevich et al. (2022) raise the question of whether it is the CENP-A nucleosome or the CCAN complex itself that provides the foundation for kinetochore as
Autor:
Robert T Wimbish, Iain M. Cheeseman, Ekaterina V. Tarasovetc, Praveen Kumar Allu, Jennifer G. DeLuca, Ekaterina L. Grishchuk, Ben E. Black
Publikováno v:
Molecular Biology of the Cell
Mitotic kinetochores assemble via the hierarchical recruitment of numerous cytosolic components to the centromere region of each chromosome. However, how these orderly and localized interactions are achieved without spurious macromolecular assemblies
The centromere comes into focus: from CENP-A nucleosomes to kinetochore connections with the spindle
Publikováno v:
Open Biology
Open Biology, Vol 10, Iss 6 (2020)
Open Biology, Vol 10, Iss 6 (2020)
Eukaryotic chromosome segregation relies upon specific connections from DNA to the microtubule-based spindle that forms at cell division. The chromosomal locus that directs this process is the centromere, where a structure called the kinetochore form