Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Robert A. Lazarus"'
Autor:
David Arnott, Helga Raab, Sherron Bullens, Lilian Phu, Charles Eigenbrot, Henry R. Maun, Robert A. Lazarus
Publikováno v:
Protein Science. 14:1171-1180
Proteolytic processing of zymogen Factor VII to Factor VIIa (FVIIa) is necessary but not sufficient for maximal proteolytic activity, which requires an additional allosteric influence induced upon binding to its cofactor tissue factor (TF). A key con
Publikováno v:
Biochemistry. 34:10383-10392
Surface plasmon resonance (SPR) measurements on a BIAcore instrument have been used to measure the effects of mutations in human tissue factor (TF), the initiator of blood coagulation, on the kinetics and affinity of binding to human FVIIa. TF mutant
Publikováno v:
The Biochemical journal. 363(Pt 2)
Highly potent bifunctional inhibitors of Factor VIIa (FVIIa) were generated by linking two distinct peptides, recently shown to bind to two discrete exosites on the FVIIa protease domain [Dennis, Eigenbrot, Skelton, Ultsch, Santell, Dwyer, O'Connell
Publikováno v:
Biochemistry. 40(32)
A new series of peptide inhibitors of human Factor VIIa (FVIIa) has been identified and affinity matured from naive and partially randomized peptide phage libraries selected against the immobilized tissue factor x Factor VIIa (TF x FVIIa) complex. Th
Autor:
Lydia Santell, Martin Roberge, Robert A. Lazarus, Charles Eigenbrot, Mark S. Dennis, Mary A. Dwyer
Publikováno v:
Biochemistry. 40(32)
A new inhibitory peptide binding exosite on the protease domain of coagulation Factor VIIa (FVIIa) has been identified. A novel series of peptide inhibitors of FVIIa, termed the "A-series" peptides, identified from peptide phage libraries and exempli
Autor:
Robert A. Lazarus, Clark Q. Pan
Publikováno v:
Biochemistry. 36(22)
Human deoxyribonuclease I (DNase I), an enzyme used to treat cystic fibrosis patients, has been engineered to more effectively degrade double-stranded DNA to lower molecular weight fragments by altering its functional mechanism from the native single
Autor:
Daniel G. Yansura, Barbara Moffat, Dorothea Reilly, Mark S. Dennis, Robert N. Lindquist, Mary E. Wessinger, Robert A. Lazarus, Jana L. Seymour
Publikováno v:
Biochemistry. 33(13)
Ecotin, a serine protease inhibitor found in the periplasm of Escherichia coli, has been characterized as an extremely potent anticoagulant and reversible tight-binding inhibitor of human factor Xa (FXa). The ecotin gene was cloned by PCR, highly exp
Publikováno v:
Journal of Experimental Zoology. 222:129-136
The effects of temperature on the firing patterns of the excitatory motor supply to the bender muscle were examined in autotomized walking limbs of the crab Pachygrapsus crassipes. A brief electrical shock applied to the limb nerve evoked an action p
Publikováno v:
FEBS Letters. (2-3):159-163
Ecotin, a serine protease inhibitor found in the periplasm of Escherichia coli , has been characterized as a potent reversible tight-binding inhibitor of the human contact activation proteases factor XIIa (FXIIa) and plasma kallikrein, having K i val
Publikováno v:
Journal of medicinal chemistry. 26(4)
Reaction of diethyl chloromalonate with beta-mercapto amines, 9, gave 1,4-thiazin-3-ones, 10, which were alkylated exclusively at the lactam oxygen with triethyloxonium tetrafluoroborate and subsequently condensed with guanidine to give the first rep