Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Michael T. Wilson"'
Autor:
Dimitri A. Svistunenko, Jonathan A. R. Worrall, Michael T. Wilson, Robin L. Owen, Marina Lučić, Michael A. Hough
Publikováno v:
Journal of Biological Inorganic Chemistry
Structure determination of proteins and enzymes by X-ray crystallography remains the most widely used approach to complement functional and mechanistic studies. Capturing the structures of intact redox states in metalloenzymes is critical for assigni
Autor:
Michael T. Wilson, Marina Lučić, Amanda K. Chaplin, T. Moreno-Chicano, Florian S. N. Dworkowski, Michael A. Hough, Jonathan A. R. Worrall, Dimitri A. Svistunenko
Publikováno v:
Dalton Transactions. 49:1620-1636
Dye decolourising peroxidases (DyPs) are oxidative haem containing enzymes that can oxidise organic substrates by first reacting with hydrogen peroxide. Herein, we have focused on two DyP homologs, DtpAa and DtpA, from the soil-dwelling bacterium Str
Publikováno v:
Chemistry – A European Journal. 25:10678-10688
The chemical basis for protecting organisms against the toxic effect imposed by excess cuprous ions is to constrain this through high-affinity binding sites that use cuprous-thiolate coordination chemistry. In bacteria, a family of cysteine rich four
Publikováno v:
Free Radical Biology & Medicine
Covalent hemoglobin binding to membranes leads to band 3 (AE1) clustering and the removal of erythrocytes from the circulation; it is also implicated in blood storage lesions. Damaged hemoglobin, with the heme being in a redox and oxygen-binding inac
Autor:
Jonathan A. R. Worrall, Michael A. Hough, Tadeo Moreno Chicano, Amanda K. Chaplin, Dimitri A. Svistunenko, Bethany V. Hampshire, Michael T. Wilson
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 25(24)
Dye decolouring peroxidases (DyPs) are the most recent class of heme peroxidase to be discovered. On reacting with H2 O2 , DyPs form a high-valent iron(IV)-oxo species and a porphyrin radical (Compound I) followed by stepwise oxidation of an organic
Autor:
Michael T. Wilson, Geoffrey R. Moore, Jonathan A. R. Worrall, Oliver M. Deacon, Dimitri A. Svistunenko
Publikováno v:
Biochemistry. 57(29)
Naturally occurring mutations found in one of the two Ω-loop substructures in human cytochrome c are associated with low blood platelet count (thrombocytopenia). Both Ω-loops participate in the formation of conformers associated with cytochrome c p
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 46(29)
Dye decolourising peroxidases are the most recent family of haem peroxidases to be discovered. The oxidising potential of these enzymes is driven by the formation of ferryl intermediates that enables them to oxidise synthetic dye molecules that are w
Autor:
Michael A. Hough, Amanda K. Chaplin, Jonathan A. R. Worrall, Dimitri A. Svistunenko, Erik Vijgenboom, Michael T. Wilson
Publikováno v:
Biochemical Journal, 474(5), 809-825
Biochemical Journal
Biochemical Journal
GlxA from Streptomyces lividans is a mononuclear copper-radical oxidase and a member of the auxiliary activity family 5 (AA5). Its domain organisation and low sequence homology make it a distinct member of the AA5 family in which the fungal galactose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9a274b4a058c3adb0e223bbf8efea6
https://doi.org/10.1042/bcj20160968
https://doi.org/10.1042/bcj20160968
Autor:
Michael T. Wilson, Andreas Ioannis Karsisiotis, Colin J. Macdonald, Tharin M. A. Blumenschein, Geoffrey R. Moore, Oliver M. Deacon, Jonathan A. R. Worrall
Publikováno v:
Scientific Reports
Thrombocytopenia 4 is an inherited autosomal dominant thrombocytopenia, which occurs due to mutations in the human gene for cytochrome c that results in enhanced mitochondrial apoptotic activity. The Gly41Ser mutation was the first to be reported. He
Autor:
Gary Silkstone, Badri S. Rajagopal, Michael T. Wilson, Peter Nicholls, Jonathan A. R. Worrall
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1817:780-791
Mitochondrial cytochrome c associates with the phosphoplipid cardiolipin (CL) through a combination of electrostatic and hydrophobic interactions. The latter occurs by insertion into cytochrome c of an acyl chain, resulting in the dissociation of the