Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jae J. Song"'
Publikováno v:
Cellular Signalling. 25:1288-1300
Curcumin as an anticancer agent was investigated in regards to its ability to regulate the switching of cancer cells from survival to necrotic cell death. At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylatio
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Cellular Signalling. 20:892-906
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis through caspase activation in a number of cancer cell lines while displaying minimal or no toxicity on normal cells, suggesting that this protein may h
Publikováno v:
Clinical Cancer Research. 11:7607-7613
Purpose and Experimental Design: Previously, we observed that the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK1) is mediated through the activation of apoptosis signal–regulating kinase 1 (ASK1) as a
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Journal of Cell Biology. 170:61-72
We have previously observed that metabolic oxidative stress–induced death domain–associated protein (Daxx) trafficking is mediated by the ASK1–SEK1–JNK1–HIPK1 signal transduction pathway. The relocalized Daxx from the nucleus to the cytopla
Autor:
Jae J. Song, Yong J. Lee
Publikováno v:
Biochemical Journal. 373:845-853
Redox-sensing molecules such as thioredoxin (TRX) and glutaredoxin (GRX) bind to apoptosis signal-regulating kinase 1 (ASK1) and suppress its activation. Glucose deprivation disrupted the interaction between TRX/GRX and ASK1 and subsequently activate
Autor:
Yong J. Lee, Jae J. Song
Publikováno v:
Journal of Cellular Biochemistry. 89:653-662
Recently, acute total glucose deprivation has been shown to cause activation of ASK1-MEK-MAPK signal transduction and dissociation of glutaredoxin (GRX) from apoptosis signal-regulating kinase 1 (ASK1). In this study, we investigated whether clinical
Publikováno v:
Molecular Pharmacology. 62:1409-1417
We observed previously that glucose deprivation induces cytotoxicity, increases the intracellular levels of hydroperoxide, and activates the stress-activated protein kinase (SEK) pathway. In this study, we hypothesized that 1-methylpropyl 2-imidazoly
Autor:
Juong G. Rhee, Susan A. Walsh, Jae J. Song, Yong J. Lee, Douglas R. Spitz, Mohan Suntharalingam
Publikováno v:
Journal of Biological Chemistry. 277:46566-46575
Epitope-tagged glutaredoxin (GRX) was utilized to determine the role of GRX in oxidative stress-induced signaling and cytotoxicity in glucose-deprived human cancer cells (MCF-7/ADR and DU-145). GRX-overexpressing cells demonstrated resistance to gluc
Publikováno v:
Cellular signalling. 25(1)
Previously, we showed that mitogen-activated protein kinase/extracellular signal-related kinase 4 (MEKK4) is responsible for p38 activation and that its activation during tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) treatment also
Autor:
So Y. Kim, Bo K. Sun, Sujin Choi, Jae J. Song, Hoan N. Nguyen, Hye Jin Choi, Seeun Oh, Yong J. Lee, Joo Hang Kim
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to activate mitogen-activated protein kinases (MAPKs) depending on caspase and mammalian sterile 20-like kinase 1 activations. However, the upstream molecule of MAPKs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c65566c90effa191f4b761bc0419ee
https://europepmc.org/articles/PMC3041593/
https://europepmc.org/articles/PMC3041593/