Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Maria Diaz"'
Autor:
Kevin G. Shim, Timothy Kottke, Nicolas Boisgerault, Kevin J. Harrington, Shane Zaidi, Jill Thompson, Laura Evgin, Peter Selby, Diana Rommelfanger, Hardev Pandha, Richard G. Vile, Rosa Maria Diaz, Elizabeth Ilett, Alan Melcher, Matthew C. Coffey
Understanding how incompletely cleared primary tumors transition from minimal residual disease (MRD) into treatment-resistant, immune-invisible recurrences has major clinical significance. We show here that this transition is mediated through the sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de43de651a3b9fba7a3b2ea55d6d0393
https://europepmc.org/articles/PMC5858196/
https://europepmc.org/articles/PMC5858196/
Autor:
Alan Melcher, Oliver Donnelly, Jill Thompson, Hardev Pandha, Candice Willmon, Matthew C. Coffey, Kevin J. Harrington, Shane Zaidi, Rosa Maria Diaz, Peter Selby, Timothy Kottke, Richard G. Vile, Elizabeth Ilett
Publikováno v:
Molecular Therapy. 22(10):1851-1863
Optimum clinical protocols require systemic delivery of oncolytic viruses in the presence of an intact immune system. We show that preconditioning with immune modulators, or loading virus onto carrier cells ex vivo, enhances virus-mediated antitumor
Autor:
Gerard J. Nuovo, Timothy Kottke, Kevin J. Harrington, Alan Melcher, Debabrata Mukhopadhyay, Peter Selby, Jill Thompson, Richard G. Vile, Jose S. Pulido, Matthew C. Coffey, Rosa Maria Diaz, Hardev Pandha, Elizabeth Ilett, John D. Chester
Publikováno v:
Molecular Therapy. 19(10):1802-1812
We have previously reported that a burst of vascular endothelial growth factor (VEGF) signaling to tumor-associated endothelium induces a proviral state, during which systemically delivered oncolytic reovirus can replicate in endothelium, thereby ind
Autor:
Alan Melcher, Feorillo Galivo, Jill Thompson, Kevin J. Harrington, Steven M. Albelda, Rosa Maria Diaz, Timothy Kottke, Phonphimon Wongthida, Candice Willmon, Richard G. Vile
Publikováno v:
Molecular Therapy. 19(1):140-149
Despite having potent oncolytic activity, in vitro, direct intratumoral injection of oncolytic vesicular stomatitis virus (VSV) into established AE17ova mesothelioma tumors in C57Bl/6 mice had no therapeutic effect. During studies to combine systemic
Autor:
Scott E. Strome, Timothy Kottke, Phonphimon Wongthida, Candice Willmon, Feorillo Galivo, Richard G. Vile, Jose S. Pulido, John D. Chester, Alan Melcher, Kevin J. Harrington, Rosa Maria Diaz, Peter Selby, Karen M. Kaluza, Glen N. Barber, Jill Thompson
Publikováno v:
Molecular Therapy. 16(12):1910-1918
To protect viral particles from neutralization, sequestration, nonspecific adhesion, and mislocalization following systemic delivery, we have previously exploited the natural tumor-homing properties of antigen-specific CD8+ T cells. Thus, OT-I T cell
Autor:
Mikael Valdes, Rosa Maria Diaz, Feorillo Galivo, Glen N. Barber, Phonphimon Wongthida, Timothy Kottke, Richard G. Vile, Jian Qiao, Jill Thompson
Publikováno v:
Cancer Research. 67:2840-2848
Relatively little attention has been paid to the role of virotherapy in promoting antitumor immune responses. Here, we show that CD8+ T cells are critical for the efficacy of intratumoral vesicular stomatitis virus virotherapy and are induced against
Autor:
Jill Thompson, Timothy Kottke, Jose S. Pulido, Rosa Maria Diaz, Richard G. Vile, Feorillo Galivo, Phonphimon Wongthida, Alan Melcher, Larry R. Pease, Kevin D. Pavelko
Innate immune effector mechanisms triggered by oncolytic viruses may contribute to the clearance of both infected and uninfected tumor cells in immunocompetent murine hosts. Here, we developed an in vitro tumor cell/bone marrow coculture assay and us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bbc3b37fe5741984a5c61681073a1a
https://europepmc.org/articles/PMC3896099/
https://europepmc.org/articles/PMC3896099/