Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Carol A. Pollock"'
Autor:
Anthony J. Gill, Martin E. Gosnell, Saabah B. Mahbub, Ewa M. Goldys, Jared M. Campbell, Abbas Habibalahi, Muh Geot Wong, Long T. Nguyen, Carol A. Pollock, Ayad G. Anwer, Uzair M. Qadri, Angela Chou, Sonia Saad
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Optimally preserved urinary exfoliated renal proximal tubule cells were assessed by multispectral imaging of cell autofluorescence. We demonstrated different multispectral autofluorescence signals in such cells extracted from the urine of patients wi
Autor:
Adeera Levin, Rose Qiu, Dick de Zeeuw, David M. Charytan, David C. Wheeler, Christopher P. Cannon, Bernard Zinman, Meg Jardine, Harpreet S. Bajaj, Gian Luca Di Tanna, Rajiv Agarwal, Kenneth W. Mahaffey, Megumi Oshima, Vlado Perkovic, Hiddo J.L. Heerspink, Carol A. Pollock, Bruce Neal, Hong Zhang, Norman Rosenthal, George L. Bakris, Zien Zhou, Scott Bull, Tao Sun, Tom Greene
Publikováno v:
Journal of the American Society of Nephrology, 31(5), 1128-1139. AMER SOC NEPHROLOGY
J Am Soc Nephrol
J Am Soc Nephrol
BACKGROUND: Canagliflozin reduced renal and cardiovascular events in people with type 2 diabetes in the CREDENCE trial. We assessed efficacy and safety of canagliflozin by initial estimated glomerular filtration rate (eGFR). METHODS: CREDENCE randoml
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cc49e0de93f3c4191f2b4825756550
https://research.rug.nl/en/publications/05e58d3f-d008-43f7-9d77-9bc4dfb474fe
https://research.rug.nl/en/publications/05e58d3f-d008-43f7-9d77-9bc4dfb474fe
Autor:
Qinghua Cao, Carol A. Pollock, Jason Chen, Ying Shi, Yongli Zhao, Chunling Huang, Ling Zhang, Hao Yi, Xin-Ming Chen
Publikováno v:
Journal of cellular physiology. 233(9)
Progressive tubulointerstitial fibrosis has been recognized as a common pathological process that leads to the progression of all chronic kidney disease (CKD). Innovative strategies are needed to both prevent and treat CKD. Inflammatory and fibrotic
Publikováno v:
Laboratory Investigation. 94:309-320
Thioredoxin-interacting protein (TXNIP) expression is ubiquitous and is induced by a variety of cellular stresses, including high intracellular glucose. TXNIP is associated with activation of oxidative stress and tubulointerstitial fibrosis in diabet
Autor:
Murali Gangadharan Komala, Carol A. Pollock, Usha Panchapakesan, Steven J. Chadban, Huiling Wu, Harshini Mudaliar
Publikováno v:
American Journal of Physiology-Renal Physiology. 305:F143-F154
Inflammatory responses are central to the pathogenesis of diabetic nephropathy. Toll-like receptors (TLRs) are ligand-activated membrane-bound receptors which induce inflammatory responses predominantly through the activation of NF-κB. TLR2 and 4 ar
Publikováno v:
American Journal of Physiology-Renal Physiology. 304:F1266-F1273
MicroRNAs (miRNAs) comprise of a novel class of endogenous small noncoding RNAs that frequently downregulate the expression of target genes. Recent reports suggest that miRNA-200b prevents epithelial-to-mesenchymal transition (EMT) in cancer cells by
Publikováno v:
Scientific Reports
Autophagy is emerging as an important pathway in many diseases including diabetic nephropathy. It is acknowledged that oxidative stress plays a critical role in autophagy dysfunction and diabetic nephropathy and KCa3.1 blockade ameliorates diabetic r
Publikováno v:
American Journal of Physiology-Renal Physiology. 301:F84-F93
Hyperglycemia and hypoxia have independent and convergent roles in the development of renal disease. Transforming growth factor-β1(TGF-β1) is a key cytokine promoting the production of extracellular matrix proteins. The cationic-independent mannose
Autor:
Xin-Ming Chen, Siska Sumual, Owen Tang, Stella McGinn, Sonia Saad, Rachel Yong, Carol A. Pollock
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 42:1689-1697
The centrality of the transcriptional regulator Snail in epithelial-to-mesenchymal transformation (EMT), known to occur in models of diabetic nephropathy, has not been established. Transforming growth factor beta-1 (TGFbeta1) is induced in diabetic n
Autor:
Andrew M. Herzenberg, Darren J. Kelly, Sih Min Tan, Robyn G Langham, Hans-Henrik Parving, Yuan Zhang, Andrew Advani, Renae M. Gow, Kerri Thai, Weier Qi, Carol A. Pollock, Alison J. Cox, Kim A. Connelly, Richard E. Gilbert, Per K. Christensen
Publikováno v:
Journal of the American Society of Nephrology. 20:730-741
Excessive reactive oxygen species play a key role in the pathogenesis of diabetic nephropathy, but to what extent these result from increased generation, impaired antioxidant systems, or both is incompletely understood. Here, we report the expression