Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Nadia J. Kershaw"'
Autor:
Sandra E. Nicholson, Rebecca Feltham, Andrew J. Brooks, Nadia J. Kershaw, Colin Hockings, Cyrus Tan, Sachdev S. Sidhu, Kunlun Li, Shawn S.-C. Li, Dale J. Calleja, Farhad Dehkhoda, Narelle Keating, Edmond M. Linossi, Gianluca Veggiani, Jeffrey J. Babon
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Paediatrics Publications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Paediatrics Publications
Suppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Signal Transducers and Activators of Transcription (STAT) signaling cascade. The central SOCS2-Src homology 2 (SH2) domain
Autor:
Nadia J. Kershaw, Artem Laktyushin, Rhiannon Morris, Nicos A. Nicola, Jarrod J. Sandow, Jeffrey J. Babon, Nicholas P. D. Liau
Publikováno v:
Cancers
Volume 11
Issue 11
Cancers, Vol 11, Iss 11, p 1701 (2019)
Volume 11
Issue 11
Cancers, Vol 11, Iss 11, p 1701 (2019)
Janus kinases (JAKs) are found constitutively associated with cytokine receptors and are present in an inactive state prior to cytokine exposure. Activating mutations of JAKs are causative for a number of leukemias, lymphomas, and myeloproliferative
Publikováno v:
Structure. 24:840-842
Janus kinases (JAKs) initiate the intracellular signaling cascade triggered by exposure of cells to cytokines and interferons. In order to achieve this, JAKs are bound to the intracellular domain of specific cytokine receptors immediately adjacent to
Publikováno v:
Growth Factors. 32:1-10
SOCS3 (Suppressor of Cytokine Signaling 3) inhibits the intracellular signaling cascade initiated by exposure of cells to cytokines. SOCS3 regulates signaling via two distinct mechanisms: directly inhibiting the catalytic activity of Janus Kinases (J
Publikováno v:
Biochemical Society Transactions. 41:1042-1047
JAKs (Janus kinases) are essential mediators of almost all biological signalling events initiated by haemopoietic and immune cytokines. However, aberrant and/or prolonged JAK-induced signalling is detrimental and can give rise to a number of inflamma
Autor:
Nadia J. Kershaw, Artem Laktyushin, Leila N. Varghese, Raymond S. Norton, Jeffrey J. Babon, Isabelle S Lucet, Nicos A. Nicola, James M. Murphy, Samuel N. Young
Publikováno v:
Immunity. 36(2):239-250
SummaryJanus kinases (JAKs) are key effectors in controlling immune responses and maintaining hematopoiesis. SOCS3 (suppressor of cytokine signaling-3) is a major regulator of JAK signaling and here we investigate the molecular basis of its mechanism
Autor:
Thomas P. J. Garrett, Douglas J. Hilton, Priscilla Soo, Michael J. Pocock, Yibin Xu, Jian-Guo Zhang, Nicos A. Nicola, Nadia J. Kershaw, Cindy S. Luo, Peter E. Czabotar
Publikováno v:
Journal of Biological Chemistry. 285:21214-21218
gp130 is the shared signal-transducing receptor subunit for the large and important family of interleukin 6-like cytokines. Previous x-ray structures of ligand-receptor complexes of this family lack the three membrane-proximal domains that are essent
Autor:
Isabelle S Lucet, Nicos A. Nicola, Nicholas P. D. Liau, Leila N. Varghese, Artem Laktyushin, Nadia J. Kershaw, James M. Murphy, Jeffrey J. Babon, Eden L Whitlock
Publikováno v:
Nature structural & molecular biology
The inhibitory protein SOCS3 plays a key part in the immune and hematopoietic systems by regulating signaling induced by specific cytokines. SOCS3 functions by inhibiting the catalytic activity of Janus kinases (JAKs) that initiate signaling within t
Publikováno v:
Cytokine. 70:21
Maintenance of the haematopoietic and immune systems is largely controlled by the secretion of cytokines. Cytokine exposure initiates an intracellular signalling cascade that is driven by activation of a family of receptor-bound tyrosine kinases know