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Autor:
Pierre Bories, Sonia Zaghdoudi, Jean-Emmanuel Sarry, Florence Castelli, Héléna Boutzen, Alexis Hucteau, Sarah Bertoli, Marie Sabatier, Ambrine Sahal, Laura Lauture, Thomas Farge, Vera Pancaldi, Emeline Chu-Van, Lucille Stuani, Emeline Boet, Nathaniel Polley, Christian Récher, Nathan Guiraud, Guillaume Cognet, Estelle Saland, Véronique Mansat-De Mas
Publikováno v:
Cancers
Volume 13
Issue 20
Cancers, Vol 13, Iss 5243, p 5243 (2021)
Volume 13
Issue 20
Cancers, Vol 13, Iss 5243, p 5243 (2021)
Simple Summary Around 15% of acute myeloid leukemia (AML) patients harbor mutations in isocitrate dehydrogenases (IDH), which lead to the production of the oncometabolite 2-hydroxyglutarate (2-HG). Inhibitors of mutant IDH enzymes and their 2-HG prod