Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Karen A. Hunt"'
Autor:
Donatella Barisani, Chris J. J. Mulder, Graham A. Heap, M.L. Mearin, Jihane Romanos, Cisca Wijmenga, Fiona M. Stevens, Gosia Trynka, Marcel Bruinenberg, David S Sanders, Graham Turner, Peter D. Howdle, Valerie Trimble, D A van Heel, Lude Franke, Wieke H. M. Verbeek, Dermot Kelleher, Alexandra Zhernakova, C. G. F. de Kovel, Karen A. Hunt, Geoffrey Holmes, Ross McManus, Julian R.F. Walters, Anthony W. Ryan, Maria Teresa Bardella, Mathieu Platteel
Publikováno v:
Gut, 58(8), 1078-1083. BMJ PUBLISHING GROUP
Gut, 58(8), 1078-1083. BMJ Publishing Group
Trynka, G, Zhernakova, A, Romanos, J, Franke, L, Hunt, K A, Turner, G A, Bruinenberg, M, Heap, G A, Platteel, M, Ryan, A, de Kovel, C, Holmes, G K, Howdle, P D, Walters, J R, Sanders, D S, Mulder, C J J, Mearin, M L, Verbeek, W H M, Trimble, V, Stevens, F M, Kelleher, D, Barisani, D, Bardella, M T, McManus, R, van Heel, D A & Wijmenga, C 2009, ' Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling ', Gut, vol. 58, no. 8, pp. 1078-1083 . https://doi.org/10.1136/gut.2008.169052
Gut, 58(8), 1078-1083. BMJ Publishing Group
Trynka, G, Zhernakova, A, Romanos, J, Franke, L, Hunt, K A, Turner, G A, Bruinenberg, M, Heap, G A, Platteel, M, Ryan, A, de Kovel, C, Holmes, G K, Howdle, P D, Walters, J R, Sanders, D S, Mulder, C J J, Mearin, M L, Verbeek, W H M, Trimble, V, Stevens, F M, Kelleher, D, Barisani, D, Bardella, M T, McManus, R, van Heel, D A & Wijmenga, C 2009, ' Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling ', Gut, vol. 58, no. 8, pp. 1078-1083 . https://doi.org/10.1136/gut.2008.169052
Objective: Our previous coeliac disease genome-wide association study (GWAS) implicated risk variants in the human leucocyte antigen (HLA) region and eight novel risk regions. To identify more coeliac disease loci, we selected 458 single nucleotide p
Autor:
Ross McManus, Neil Walker, Patrick Dubois, Cisca Wijmenga, Kate Downes, Graham A. Heap, Joanna M. M. Howson, David A. van Heel, Karen A. Hunt, Jason D. Cooper, Vincent Plagnol, John A. Todd, David Clayton, Jennie H M Yang, Helen Stevens, Deborah J. Smyth
Publikováno v:
New England Journal of Medicine, 359(26), 2767-2777. MASSACHUSETTS MEDICAL SOC
Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin. Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shar
Autor:
Kenichi Negoro, Dermot P.B. McGovern, Karen A. Hunt, David A. van Heel, Matt Butler, Christopher G. Mathew, Clive M. Onnie, Tariq Ahmad, Subrata Ghosh, Anna M. Lundberg, Sue Goldthorpe, Alastair Forbes, Brian M. J. Foxwell, Raymond J. Playford, Derek P. Jewell
Publikováno v:
The Lancet. 365:1794-1796
Both NOD2 (CARD15) alleles are mutated in roughly 15% of patients with Crohn's disease, but functional effects are unclear. We analysed the cytokine response of peripheral blood mononuclear cells to muramyl dipeptide (MDP), the ligand for NOD2. MDP i
Publikováno v:
European journal of immunology. 36(6)
Both NOD2/CARD15 alleles are mutated in approximately 10% of Crohn's disease patients, causing loss of functional responses to low-dose muropeptide agonists. We hypothesized that NOD2 mutations may also impair NOD1/CARD4 responses, supported by data
Autor:
Christopher G. Mathew, Alastair Forbes, D A van Heel, Subrata Ghosh, Karen A. Hunt, Derek P. Jewell, Raymond J. Playford
Publikováno v:
Gut. 54(11)
BACKGROUND: Nucleotide binding oligomerisation domain 2 (NOD2; also known as CARD15) mutations are associated with Crohn's disease but how mutations cause disease is poorly understood. Innate immune responses are reportedly enhanced by combined NOD2
Autor:
Dominique Mengin-Lecreulx, David A. van Heel, Matt Butler, Raymond J. Playford, Subrata Ghosh, Karen A. Hunt, Brian Michael J. Foxwell
Publikováno v:
European journal of immunology. 35(8)
NOD1 is an intracellular pattern-recognition receptor specific for Gram-negative peptidoglycan that is important in host response to infections (e.g. Helicobacter pylori and Shigella flexneri). Genetic variation in NOD1 predisposes to asthma and infl