Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Haigang Ren"'
Autor:
Haigang Ren, Jiayuan Wu, Meiling Sun, Qin Xia, Mei Li, Zhouteng Tao, Qingsong Hu, Lijuan Cao, Guanghui Wang, Zheng-Hong Qin, Dong Chen
Publikováno v:
Acta Pharmacologica Sinica. 36:1043-1052
In the penumbra after focal cerebral ischemia, an increase of protease Omi is linked to a decrease of Hs1-associated protein X-1 (Hax-1), a protein belonging to the Bcl-2 family. In this study we investigated the mechanisms underlying the regulation
Publikováno v:
Oncogene. 31:1311-1322
DJ-1 was initially identified as an oncogene product involved in human tumorigenesis in cooperation with Ras. Increased DJ-1 expression is associated with tumorigenesis in many cancers, whereas the loss of DJ-1 function is linked to an autosomal rece
Publikováno v:
FEBS Letters. 582:1151-1156
Sumoylation is an important post-translational modification, which is also involved in the pathogenesis of many neurodegenerative diseases. We previously reported that DJ-1 decreases Bcl-2 associated X protein expression through repressing p53 transc
Publikováno v:
Journal of Biological Chemistry. 283:4022-4030
DJ-1, originally identified as an oncogene product, is a protein with various functions in cellular transformation, oxidative stress response, and transcriptional regulation. Although previous studies suggest that DJ-1 is cytoprotective, the mechanis
Publikováno v:
Molecular Neurodegeneration, Vol 7, Iss 1, p 40 (2012)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Mutations or deletions in DJ-1/PARK7 gene are causative for recessive forms of early onset Parkinson’s disease (PD). Wild-type DJ-1 has cytoprotective roles against cell death through multiple pathways. The most commonly studied mutant D
Publikováno v:
The Journal of biological chemistry. 286(40)
Parkinson disease (PD)- and cancer-associated protein, DJ-1, mediates cellular protection via many signaling pathways. Deletions or mutations in the DJ-1 gene are directly linked to autosomal recessive early-onset PD. DJ-1 has potential roles in mito
Autor:
Guanghui Wang, Hongfeng Wang, Bin Li, Longping Wen, Na Man, Nobuyuki Nukina, Haigang Ren, Qingsong Hu, E Fei
Publikováno v:
Cell death and differentiation. 17(11)
Omi, also known as high temperature requirement factor A2 (HtrA2), is a serine protease that was originally identified as a proapoptotic protein. Like Smac/Diablo, it antagonizes inhibitor of apoptosis proteins when released into the cytosol on apopt