Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Stephen Lee"'
Autor:
Miklós Péterfy, Sarada Charugundla, Peter Tontonoz, Wenchao Zhang, Stephen Lee, Alice Mouton, Diana M. Shih, Marcus M. Seldin, Aldons J. Lusis, Zhiqiang Zhou, Prashant Rajbhandari, Fangfei Guo, Matteo Pellegrini
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific reports, vol 11, iss 1
We recently showed that NOTUM, a liver-secreted Wnt inhibitor, can acutely promote browning of white adipose. We now report studies of chronic overexpression of NOTUM in liver indicating that it protects against diet-induced obesity and improves gluc
Autor:
John Ashurst, Tyson Dietrich, Kristen Caine, Stephen Lee, Sarah Schritter, Anthony Santarelli
Publikováno v:
The Journal of the American Osteopathic Association. 120(12)
Context Following the emergence of the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), researchers sought safe and effective treatment modalities. Remdesivir is currently being eva
Autor:
Kin Sing Stephen Lee, Jian Yang, Zhexue Qin, Bruce D. Hammock, Fuhua Wu, Gang Liu, Xiao Li Jiang, Chunyu Zeng, Xiaoyong Tong, Pingping Hu, Yumei Que
Publikováno v:
Br J Pharmacol
British journal of pharmacology, vol 177, iss 8
British journal of pharmacology, vol 177, iss 8
BACKGROUND AND PURPOSE: The kidney is essential in regulating sodium homeostasis and BP. The irreversible oxidation of Cys(674) (C674) in the sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) is increased in the renal cortex of hypertensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167bce77911fad287a3e4d2012170a2e
https://europepmc.org/articles/PMC7070168/
https://europepmc.org/articles/PMC7070168/
Autor:
Jie Gao, Stephen Lee, Jason K. Kim, Daniel Lindén, In Sook Ahn, Tracy A Cole, Andrea Ahnmark, Xia Yang, Magnus Althage, Stephanie M. Correa, Frank Seeliger, Harriet Andersén, Helen Boyd, Pernilla Eliasson, Peter Tontonoz, Ingela Maxvall, J. Edward van Veen, Alba Carreras, Anna C. Calkin, Cynthia Hong, Mohammad Bohlooly-Y, Mikael Bjursell, Peter Åkerblad, Megan G. Massa, Christina Priest, Michelle J. Porritt, Graciel Diamante, Richard T. Lee, Prashant Rajbhandari, Douglas Arneson
Publikováno v:
Nature metabolism, vol 1, iss 11
Nature metabolism
Nature metabolism
Liver X receptors limit cellular lipid uptake by stimulating the transcription of Inducible Degrader of the LDL Receptor (IDOL), an E3 ubiquitin ligase that targets lipoprotein receptors for degradation. The function of IDOL in systemic metabolism is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92483fa48677032510e1ff08d752b28d
https://escholarship.org/uc/item/8xp778j5
https://escholarship.org/uc/item/8xp778j5
Publikováno v:
Abdominal Radiology. 41:677-705
Percutaneous image-guided ablation is now commonly performed in many institutions for the treatment of hepatocellular carcinoma, liver metastases, and renal cell carcinoma in select patients. Accurate interpretation of post-ablation imaging is of sup
Publikováno v:
AADE in Practice. 4:32-36
Autor:
Jian Huang, Christophe Morisseau, Da Yong Hu, Bruce D. Hammock, Chang Bin Li, Ying Luo, Jun Yang, Kin Sing Stephen Lee, Xin Kang, Ai Peng, Jun-Yan Liu, Bingqing Deng, Mingyu Wu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 47
Acute kidney injury (AKI) causes severe morbidity and mortality for which new therapeutic strategies are needed. Docosahexaenoic acid (DHA), arachidonic acid (ARA), and their metabolites have various effects in kidney injury, but their molecular mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b29fc41fb2dd153bba1b23fde9c495
https://escholarship.org/uc/item/8kp598c4
https://escholarship.org/uc/item/8kp598c4
Publikováno v:
BJU International. 116:42-48
Objective To assess the influence of tumour zonality on biochemical recurrence (BCR) after radical prostatectomy (RP) with a histologically confirmed positive surgical margin (PSM). Patients and Methods Data from 382 patients that underwent RP with e
Autor:
Bruce D. Hammock, Ming-Fo Hsu, José M. Villalba, Fawaz G. Haj, Bora Inceoglu, Darryl C. Zeldin, Yoshihiro Ito, Miguel Calvo-Rubio, Artiom Gruzdev, Shinichiro Koike, Santana Bachaalany, Ahmed Bettaieb, John D. Imig, Kin Sing Stephen Lee, Samah Chahed
Publikováno v:
Biochimica et biophysica acta. General subjects, vol 1861, iss 11 Pt A
BackgroundDiabetic nephropathy (DN) is the leading cause of renal failure, and podocyte dysfunction contributes to the pathogenesis of DN. Soluble epoxide hydrolase (sEH, encoded by Ephx2) is a conserved cytosolic enzyme whose inhibition has benefici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5567895d5c2f5b22bf30777f2cb80e
https://europepmc.org/articles/PMC5873293/
https://europepmc.org/articles/PMC5873293/
Autor:
Weicang Wang, Zhenhua Liu, Weipeng Qi, Katherine Z. Sanidad, Elvira Sukamtoh, Yeonhwa Park, Jun Yang, Kin Sing Stephen Lee, Yoshiki Nimiya, Guodong Zhang
Many studies have shown that dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) reduces the risks of colorectal cancer; however, the underlying mechanisms are not well understood. Here we used a LC-MS/MS-based lipidomics to explore the role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee6a1167eae859eabd3f0f4dfd88f83
https://europepmc.org/articles/PMC6278818/
https://europepmc.org/articles/PMC6278818/