Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Nelofer Syed"'
Publikováno v:
Neuro Oncol
Ketogenic diet (KD) has been proposed as a coadjuvant therapy in the treatment of brain tumours. Reduction of blood glucose and increase in ketone bodies concentration are amongst the most important changes induced by KD in patients. Preliminary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0002095570821fba0871182a31e48426
https://europepmc.org/articles/PMC6789991/
https://europepmc.org/articles/PMC6789991/
Autor:
Nelofer Syed, Simon Pacey, Rajesh Jena, Fiona Harris, Matthew Williams, Ramsay Khadeir, Bor-Wen Wu, Rachel Lewis, Stephen G. Ellis, Jane Evanson, Tomasz Matys, Dimitris Paraskevopoulos, John S. Bomalaski, Jim Thomson, Kate Smith, Xiaoxing Feng, R. Shaffer, Amanda Johnston, Tim Crook, Kevin O’Neill, Peter E Hall, Piers Plowman, Sarah Jefferies, Michael Sheaff, Peter W. Szlosarek
Purpose: Patients with recurrent high-grade gliomas (HGG) are usually managed with alkylating chemotherapy ± bevacizumab. However, prognosis remains very poor. Preclinically, we showed that HGGs are a target for arginine depletion with pegargiminase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::181ccb882015b1397d2e3eea9428fb31
http://hdl.handle.net/10044/1/82279
http://hdl.handle.net/10044/1/82279
Autor:
Richard Perryman, Nabil Hajji, Adrienne C. Scheck, Kevin O’Neill, Nelofer Syed, Stylianou Tzouliana, Eric C. Woolf
Glioblastoma Multiforme (GBM) is the most aggressive form of primary brain tumor, with a median survival time of just 14 months. Although a number of targeted therapies have been devised for these tumors, they have proved to be ineffective due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da022cf2f32bfac0d88b23e67d8a63c9
https://europepmc.org/articles/PMC5693004/
https://europepmc.org/articles/PMC5693004/
Autor:
Ornella Garrone, Rodolfo Brizio, Martino Monteverde, Carlo Palmieri, T Crook, C. Lo Nigro, Bharath Rudraraju, O Gojis, Laura Lattanzio, Marco Merlano, Nelofer Syed
Publikováno v:
British Journal of Cancer
Background: Calcium is an important intracellular messenger that mediates many biological processes that are relevant to the malignant process. Calcium ion channels are key in controlling the intracellular calcium, and little is known about their rol
Autor:
Richard Perryman, Nelofer Syed, Ekaterina Nevedomskaya, Shyam Solanki, Hector C. Keun, Oleg A. Mayboroda
Publikováno v:
Journal of Proteome Research, 15(1), 280-290
Altered metabolism in tumor cells is required for rapid proliferation but also can influence other phenotypes that affect clinical outcomes such as metastasis and sensitivity to chemotherapy. Here, a genome-wide association study (GWAS)-guided integr
Autor:
Stephen G. Ellis, Nelofer Syed, Ramsay Khadeir, Tim Crook, Fiona Harris, R. Shaffer, Raj Jena, John S. Bomalaski, Bor-Wen Wu, Matthew Williams, Simon Pacey, Nick Plowman, Jane Evanson, Xiaoxing Feng, Amanda Johnston, Rachel Lewis, Michael Sheaff, Jim Thomson, Peter W. Szlosarek, Peter E Hall
Publikováno v:
Journal of Clinical Oncology. 36:e14085-e14085
e14085Background: Patients (pts) with recurrent HGGs are usually managed with alkylating chemotherapy +/- bevacizumab. However, prognosis remains poor with an overall survival (OS) of 7-9 months. P...
Autor:
Bhavya Rao, Laura Lattanzio, Tim Crook, Helen M. Coley, Alistair Thompson, Nelofer Syed, Daniela Vivenza, Marco Merlano, Ornella Garrone, Cristiana Lo Nigro
Publikováno v:
Cancer Research. 77:3197-3197
Alternative RNA splicing allows processing of a pre-mRNA into various mature mRNAs. In this way multiple protein products can be derived from a single gene. In cancer it is known that specific splice variants may facilitate malignant transformation a
Autor:
Adrienne C Scheck, Sophie Glover, Quingyu Zeng, Eric C Woolf, Julianna Stylianou, Jessica Preston, Nelofer Syed, Kevin O’Neill
Publikováno v:
Neuro-Oncology. 19:i28-i28
The ketogenic diet induces epigenetic changes that impact on the expression of microRNAs and chromatin modifying enzymes that play key roles in tumour development. Jessica Preston1; Julianna Stylianou1, Quingyu Zeng1, Sophie Glover1, Kevin O’Neill1
Autor:
Tim Crook, Rubeta N Matin, Gareth J. Inman, Irene M. Leigh, Alastair M. Thompson, Catherine A. Harwood, C. Fleming, Cristiana Lo Nigro, Evangelos Briasoulis, Laura Lattanzio, Charlotte M. Proby, Hexiao Wang, Marco Merlano, Angela McHugh, Eleftheria Hatzimichael, Nelofer Syed, Alan Evans
Publikováno v:
The Journal of investigative dermatology. 133(5)
Transcriptional silencing of tissue factor pathway inhibitor 2 (TFPI2) occurs in several human tumors including melanoma. We investigated methylated TFPI2 as a biomarker of metastatic melanoma using qRT–PCR to assess TFPI2 expression and pyrosequen
Autor:
Elvio G. Russi, Alberto Comino, Tim Crook, Martino Monteverde, Marco Merlano, G. Natoli, Nelofer Syed, Ida Colantonio, Cristiana Lo Nigro, Nerina Denaro, Laura Lattanzio, Milena Gasco, Daniela Vivenza
Publikováno v:
Oral oncology. 48(7)
summary Chemo-radiotherapy (CRT) with cisplatin-based regimens is curative in a subset of patients with locally advanced (stage III and IV) squamous carcinomas of the head and neck (LAHNSCC), but causes considerable toxicity. To seek predictive bioma