Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Karel Souček"'
Autor:
Stanislav Lerch, Ján Remšík, Alois Kozubík, Monika Smějová, Jan Bouchal, Eva Slabáková, Gvantsa Kharaishvili, Zoran Culig, Milan Král, Zuzana Pernicová, Nicol Straková, Tereza Suchankova, Karel Souček
Publikováno v:
Oncotarget
// Eva Slabakova 1, 2 , Gvantsa Kharaishvili 3 , Monika Smějova 1, 4 , Zuzana Pernicova 1, 2 , Tereza Suchankova 1 , Jan Remsik 1, 2, 5 , Stanislav Lerch 1, 5 , Nicol Strakova 1, 2 , Jan Bouchal 3 , Milan Kral 6 , Zoran Culig 2, 7 , Alois Kozubik 1,
Publikováno v:
Scopus-Elsevier
We investigated hematopoiesis in untreated and ionizing radiation-exposed cyclooxygenase-2-deficient (COX-2 KO) mice. We performed a complex hematological analysis of 16 parameters in untreated COX-2 KO male mice or COX-2 KO male mice irradiated with
Publikováno v:
Differentiation. 78:213-222
Survival and capability of cancer cells to form metastases fundamentally depend on interactions with their microenvironment. Secondary tumors originating from prostate carcinomas affect remodeling of bone tissue and can induce both osteolytic and ost
Autor:
Aleš Hampl, Zuzana Pernicová, Pavel Krčmář, Alois Kozubík, Andrea Staršíchová, Eva Lincová, Karel Souček, Miroslav Machala
Publikováno v:
Biochemical Pharmacology. 78:561-572
Antitumorigenic effects of non-steroidal anti-inflammatory drugs (NSAIDs) are well established in several types of cancer disease. However, the mechanisms driving these processes are not understood in all details. In our study, we observed significan
Autor:
Viktor Horváth, Ales Kroutil, Adolf Mistr, Alois Kozubík, Petr Sova, František Žák, Jiřina Hofmanová, Jaroslav Turánek, Lenka Svihálková-Sindlerová, Karel Souček
Publikováno v:
Biochemical Pharmacology. 69:373-383
[(OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)], coded as LA-12, is an octahedral platinum(IV) complex containing a bulky hydrophobic ligand - adamantylamine. The use of bulky hydrophobic amines as non-leaving ligands, may increa
Autor:
Jiřı́ Štika, Luděk Bláha, Alois Kozubík, Kateřina Minksová, Karel Souček, Jan Vondráček, Jiřina Hofmanová
Publikováno v:
European Journal of Pharmacology. 424:1-11
We investigated whether and how could various modulators of arachidonic acid metabolism affect apoptosis induced by tumour necrosis factor-alpha (TNF-alpha) in human myeloid leukaemia HL-60 cells. These included arachinonyltrifluoromethyl ketone (AAC
Autor:
Andrea Staršíchová, Kateřina Pěnčíková, Eva Slabáková, Zuzana Pernicová, Alois Kozubík, Jan Vondráček, Miroslav Machala, Markéta Kabátková, Václav Šeda, Karel Souček, Eva Hrubá, Jiřina Procházková
Publikováno v:
Cellular signalling. 24(8)
Crosstalk between the aryl hydrocarbon receptor (AhR) and transforming growth factor-β1 (TGF-β1) signaling has been observed in various experimental models. However, both molecular mechanism underlying this crosstalk and tissue-specific context of
Publikováno v:
Human reproduction (Oxford, England). 25(12)
Transforming growth factor-β cytokines have various biological effects in female reproductive tissue, including modulation of inflammatory response and induction of immune tolerance to seminal antigens in the reproductive tract. However, no studies
Autor:
Andrea Staršíchová, Pavel Krcmar, Lenka Vykopalova, Sona Marvanová, Miroslav Machala, Helena Libalova, Alena Milcova, Eva Hrubá, Jan Vondráček, Karel Souček, Jan Topinka, Lenka Trilecová
Publikováno v:
Toxicology letters. 197(3)
Exposure to polycyclic aromatic hydrocarbons (PAHs) has been positively associated with prostate cancer, but knowledge of the formation of PAH–DNA adducts and related genotoxic events in prostatic cells is limited. In the present study, benzo[ a ]p
Autor:
Anh Phung, J. Chloë Bulinski, Jason P. Eiserich, Andrés Kamaid, Richart W Harper, Lukáš Kubala, Karel Souček
Publikováno v:
The Prostate. 66(9)
BACKGROUND Multiple diverse posttranslational modifications of α-tubulin such as detyrosination, further cleavage of the penultimate glutamate residue (Δ2-tubulin), acetylation, and polyglutamylation increase the structural and functional diversity