Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jeremie Boucher"'
Autor:
Ritesh K. Baboota, Rosa Spinelli, Malin C. Erlandsson, Bruna B. Brandao, Marsel Lino, Hong Yang, Adil Mardinoglu, Maria I. Bokarewa, Jeremie Boucher, C. Ronald Kahn, Ulf Smith
Publikováno v:
Molecular Metabolism, Vol 64, Iss , Pp 101558- (2022)
Objective: Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging-
Externí odkaz:
https://doaj.org/article/82af05ba8e3a4d02a32750880a3b60a8
Autor:
Jenny M. Hoffmann, John R. Grünberg, Ann Hammarstedt, Tobias Kroon, Thomas U. Greiner, Stefanie Maurer, Ivet Elias, Vilborg Palsdottir, Fatima Bosch, Jeremie Boucher, Shahram Hedjazifar, Ulf Smith
Publikováno v:
Molecular Metabolism, Vol 32, Iss , Pp 15-26 (2020)
Objective: Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WA
Externí odkaz:
https://doaj.org/article/f9ddf0eaf4ad46ecababbbec31f4fdd4
Autor:
Tobias Kroon, Matthew Harms, Stefanie Maurer, Laurianne Bonnet, Ida Alexandersson, Anna Lindblom, Andrea Ahnmark, Daniel Nilsson, Peter Gennemark, Gavin O'Mahony, Victoria Osinski, Coleen McNamara, Jeremie Boucher
Publikováno v:
Molecular Metabolism, Vol 36, Iss , Pp - (2020)
Objective: Peroxisome proliferator-activated receptors (PPARs) are key transcription factors that regulate adipose development and function, and the conversion of white into brown-like adipocytes. Here we investigated whether PPARα and PPARγ activa
Externí odkaz:
https://doaj.org/article/c8f7d5b18d4a454e9d17350c34792a8f
Autor:
Ritesh K. Baboota, Aidin Rawshani, Laurianne Bonnet, Xiangyu Li, Hong Yang, Adil Mardinoglu, Tamar Tchkonia, James L. Kirkland, Anne Hoffmann, Arne Dietrich, Jeremie Boucher, Matthias Blüher, Ulf Smith
Publikováno v:
Nature Metabolism. 4:1007-1021
The role of hepatic cell senescence in human non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is not well understood. To examine this, we performed liver biopsies and extensive characterization of 58 individuals with
Autor:
TOBIAS KROON, THERESE HAGSTEDT, IDA ALEXANDERSSON, ANNETT FERM, MARIE PETERSSON, STEFANIE MAURER, BADER ZARROUKI, KRISTINA WALLENIUS, NICHOLAS D. OAKES, JEREMIE BOUCHER
Publikováno v:
Diabetes. 71
Circadian rhythms play critical roles in regulating metabolism, including daily feeding/fasting periods and oscillating expressions of certain genes. Glucokinase (Gck) , expressed in the liver and pancreas, is central for whole-body glucose homeostas
Autor:
Miguel A. Lanaspa, C. Ronald Kahn, Samir Softic, Senad Divanovic, Richard J. Johnson, Kimber L. Stanhope, Jeremie Boucher
Publikováno v:
Crit Rev Clin Lab Sci
Excessive caloric intake in a form of high-fat diet (HFD) was long thought to be the major risk factor for development of obesity and its complications, such as fatty liver disease and insulin resistance. Recently, there has been a paradigm shift and
Autor:
Vilborg Palsdottir, Ann Hammarstedt, Thomas U. Greiner, Ivet Elias, Stefanie Maurer, Tobias Kroon, Fatima Bosch, Shahram Hedjazifar, John R. Grünberg, Jenny M. Hoffmann, Jeremie Boucher, Ulf Smith
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 32, Iss, Pp 15-26 (2020)
Molecular Metabolism, Vol 32, Iss, Pp 15-26 (2020)
Objective Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT
Autor:
Jenny M. Hoffmann, Ivet Elias, Roxana Khatib Shahidi, Jeremie Boucher, Ann Hammarstedt, Christopher Church, Shahram Hedjazifar, Fatima Bosch, Laurianne Bonnet, Ritesh K. Baboota, Ulf Smith, Stephanie Heasman
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247300 (2021)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
PLoS ONE
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
PLoS ONE
Objective Gremlin 1 (GREM1) is a secreted BMP2/4 inhibitor which regulates commitment and differentiation of human adipose precursor cells and prevents the browning effect of BMP4. GREM1 is an insulin antagonist and serum levels are high in type 2 di
Autor:
Anna Lindblom, Andrea Ahnmark, Matthew J. Harms, Stefanie Maurer, Tobias Kroon, Laurianne Bonnet, Daniel Nilsson, Victoria Osinski, Jeremie Boucher, Ida Alexandersson, Peter Gennemark, Gavin O'Mahony, Coleen A. McNamara
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 36, Iss, Pp-(2020)
Molecular Metabolism, Vol 36, Iss, Pp-(2020)
Objective Peroxisome proliferator-activated receptors (PPARs) are key transcription factors that regulate adipose development and function, and the conversion of white into brown-like adipocytes. Here we investigated whether PPARα and PPARγ activat
Autor:
Lars Löfgren, Ann Kjellstedt, Tobias Kroon, Therese Hagstedt, Kristina Wallenius, Anna Lindblom, Jeremie Boucher, Daniel Lindén, Maria Sörhede Winzell
Publikováno v:
Diabetes. 68
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are effective treatments for improving glucose control and reducing cardiovascular events in patients with T2D. In the present study we examined the metabolic effects of chronic treatment of the SGLT