Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Dalian Ding"'
Autor:
Hong Sun, Jeanne M. Manalo, Dalian Ding, John Hicks, Richard Salvi, Fred A. Pereira, Rodney E. Kellems, Yang Xia, Hong Liu
Publikováno v:
The FASEB Journal. 34:15771-15787
Over 466 million people worldwide are diagnosed with hearing loss (HL). About 90% of HL cases are sensorineural HL (SNHL) with treatments limited to hearing aids and cochlear implants with no FDA-approved drugs. Intriguingly, ADA-deficient patients h
Autor:
Dalian Ding, Haibo Shi, Richard Salvi, Yazhi Xing, Jianghui Zhang, Peng Li, Fang Liu, Weidong Qi, Haiyan Jiang, Hong Sun, Shankai Yin
Publikováno v:
Journal of Otology
Journal of Otology, Vol 15, Iss 1, Pp 36-40 (2020)
Journal of Otology, Vol 15, Iss 1, Pp 36-40 (2020)
The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress. However, little is known about fighting oxidat
Autor:
Aaron S. Gomez, Yong Hwan Kim, Thomas C. Foster, Mi-Jung Kim, Christina Rothenberger, Upal Bose, Richard Salvi, Isabela Caicedo, Karessa White, Senthilvelan Manohar, Hyo-Jin Park, Dalian Ding, Masaru Tanokura, Edith M. Sampson, Maria S. Ticsa, Paul J. Linser, Ashok V. Kumar, Shinichi Someya, Takuya Miyakawa, Chul Han, Kevin Boyd
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α4 (GSTA4), a member of the Phase II deto
Publikováno v:
Neurotox Res
Paraquat, a superoxide generator, can damage the cochlea causing an ototoxic hearing loss. The purpose of the study was to determine if deletion of Bak, a pro-apoptotic gene, would reduce paraquat ototoxicity or if deletion of Sirt3, which delays age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5198635a5e5780e596a3acdf24cd7f64
https://europepmc.org/articles/PMC8277768/
https://europepmc.org/articles/PMC8277768/
Publikováno v:
Neurotox Res
2-Hydroxypropyl-β-cyclodextrin (HPβCD), a cholesterol chelator, is being used to treat diseases associated with abnormal cholesterol metabolism such as Niemann-Pick C1 (NPC1). However, the high doses of HPβCD needed to slow disease progression may
Autor:
Shinichi Someya, Kevin Boyd, Hyo-Jin Park, Dalian Ding, Chul Han, Richard Salvi, Karessa White, Mi-Jung Kim
Publikováno v:
Exp Gerontol
The glutathione transferase (GST) detoxification system converts exogenous and endogenous toxins into a less toxic form by conjugating the toxic compound to reduced glutathione (GSH) by a variety of GST enzymes. Of the ~20 GST isoforms, GSTA4 exhibit
Autor:
Shinichi Someya, Sanford L. Boye, Kaitlyn R. Calabro, Dalian Ding, Mi-Jung Kim, Richard Salvi, Sean Crosson, Diego Fajardo, Shannon E. Boye, Shreyasi Choudhury, Jim Peterson, Wei Li
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience, Vol 13 (2019)
Usher's syndrome is the most common combined blindness-deafness disorder with USH1B, caused by mutations in MYO7A, resulting in the most severe phenotype. The existence of numerous, naturally occurring shaker1 mice harboring variable MYO7A mutations
Autor:
Dalian Ding, Guang-Di Chen, Richard Salvi, Damian M. Daszynski, Haiyan Jiang, Theodor A Woolman, Karen Blessing, Peter F. Kador
Publikováno v:
Hear Res
Oxidative stress is a major contributor to noise-induced hearing loss, the most common cause of hearing loss among military personnel and young adults. HK-2 is a potent, orally-active, multifunctional, redox-modulating drug that has been shown to pro
Autor:
Weidong Qi, Yongqi Li, Hong Liu, Kenneth W. Gross, Dalian Ding, Richard Salvi, Haiyan Jiang, Hong Sun, Xuewen Wu
Publikováno v:
Journal of Otology, Vol 11, Iss 4, Pp 145-156 (2016)
Over the past two decades considerable progress has been made in understanding the ototoxic effects and mechanisms underlying loop diuretics. As typical representative of loop diuretics ethacrynic acid or furosemide only induces temporary hearing los
Autor:
Henry V. Baker, Chul Han, Mi-Jung Kim, Hyo-Jin Park, Dalian Ding, Yanping Zhang, Senthilvelan Manohar, Masaru Tanokura, Paul J. Linser, Shinichi Someya, Yong Hwan Kim, Richard Salvi, Karessa White, Maria-Cecilia Lopez, Christiaan Leeuwenburgh
Publikováno v:
The Journal of Neuroscience. 36:11308-11319
Regular physical exercise reduces the risk for obesity, cardiovascular diseases, and disability and is associated with longer lifespan expectancy (Taylor et al., 2004; Pahor et al., 2014; Anton et al., 2015; Arem et al., 2015). In contrast, decreased