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Autor:
Jan Örberg, Carina Ingvast
Publikováno v:
Acta Pharmacologica et Toxicologica. 41:11-17
Effects of two pure chlorobiphenyls (2,4′,5-trichlorobiphenyl or 2,2′,4,4′,5,5′-hexachlorobiphenyl) on the hepatic drug metabolizing system and on the elimination rate of 14C from the blood after intravenous injection of 4-14C- progesterone h
Publikováno v:
Acta Pharmacologica et Toxicologica. 58:61-70
A number of potential neuroleptic drugs of the substituted benzamide type have been compared with some reference neuroleptic drugs regarding their affinities for rat brain receptors using in vitro receptor binding techniques. The effects on dopamine-
Autor:
Lena A. C. Smith, Bengt J. Meyerson
Publikováno v:
Acta Pharmacologica et Toxicologica. 55:194-198
The effect of lysergic acid diethylamide (LSD) on copulatory and exploratory behaviour in hormone-treated, ovariectomized rats was investigated 4 weeks after chronic treatment with either saline or zimeldine (ZIM). A decrease in sensitivity to the lo
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:88-91
The effect of manganese on free polysomal protein synthesis of immature rat brain (3 weeks old) has been determined after 1, 2, 3, and 4 weeks of daily intake of 55 micrograms manganese/ml of drinking water. The protein synthesis was inhibited up to
Publikováno v:
Acta Pharmacologica et Toxicologica. 54:177-182
Conscious rats were given intracerebral injections by preplaced microsyringes. The injectates were 0.3-0.5 microliters of 125I- and 131I-o-iodohippurate. One hour after injection the isotopes present in the unopened cranial cavity were measured by ga
Autor:
P. B. Vendsborg
Publikováno v:
Acta Pharmacologica et Toxicologica. 48:326-329
The distribution of an intravenous glucose load was investigated in rats without and with previous lithium administration. Lithium caused an increased rate of glycogen formation in muscle tissue but not in liver tissue. Uptake of a 14C-labelled gluco
Autor:
Nils-Erik Andén, Helmut Wachtel
Publikováno v:
Acta Pharmacologica et Toxicologica. 40:310-320
Baclofen (beta-parachlorophenyl-GABA) caused an increase in the concentration of dopamine in the rat brain with a maximum of about 170% of the control value after 1 hr and after doses of 50 mg/kg or more intraperitoneally. The alpha-methyltyrosine-in
Publikováno v:
Acta Pharmacologica et Toxicologica. 59:113-122
The elimination of felodipine in liver microsomes from dog and man were characterized by Km and Vmax. The results were compared with previous data reported for rat. In all species studied, felodipine was primarily metabolized to its corresponding pyr
Autor:
R. Klysner, A. Geisler
Publikováno v:
Acta Pharmacologica et Toxicologica. 56:1-5
Lithium (5 and 20 mM) was found to inhibit the dopamine-stimulated cyclic AMP formation in homogenates from rat striatum and olfactory tubercle, leaving basal and fluoride-stimulated activities unaffected. The inhibition of dopamine-stimulated adenyl
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:3-11
The partial beta-agonist prenalterol has been found to differ from the full agonist isoprenaline in some aspects of its cardiac action. We therefore studied in rat myocardium whether prenalterol elicited the same qualitative changes of the contractio