Zobrazeno 51 - 60
of 15 774
pro vyhledávání: ''
Publikováno v:
Acta Pharmacologica et Toxicologica. 59:291-297
Apomorphine, a dopamine agonist with high affinity for presynaptic dopamine receptors, caused dose-dependent inhibition (10-300 micrograms/kg intravenously) of the stimulation-induced increase in diastolic blood pressure in the pithed rat. This effec
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:321-327
The involvement of hyperosmolarity in ethanol-induced gastric mucosal damage was studied by comparing the effects of ethanol on the rat gastric mucosa and those caused by hyperosmotic glucose and choline chloride solutions, and by an almost isosmotic
Autor:
Harald Olsen
Publikováno v:
Acta Pharmacologica et Toxicologica. 50:67-74
The actylation of sulfanilamide and procainamide in suspensions of isolated rat parenchymal cells was studied in absence and presence of ethanol (33 mM), acetate (0.5–5 mM), citrate (4 mM), pyruvate (4 mM), and L(minus;)carnitine (2 mM). Ethanol tr
Publikováno v:
Acta Pharmacologica et Toxicologica. 47:355-358
The fluoride sensitivity, determined as effect on protein synthesis (incorporation of 14C-leucine), of liver and kidney cells in suspension culture was explored. The cells were freshly prepared by collagenase perfusion from rats given drinking water
Publikováno v:
Acta Pharmacologica et Toxicologica. 59:377-381
This paper examines a possible interaction between non-steroid antiinflammatory drugs (NSAI drugs) and renal lithium clearance in conscious, unoperated rats with diabetes insipidus (Brattleboro strain) and ordinary Wistar rats. The drugs were given w
Autor:
Eva Jennische, Ivar Lönnroth
Publikováno v:
Acta Pharmacologica et Toxicologica. 50:305-309
The effect of chlorpromazine (CPZ) on net fluid transport in the small intestine of the rat was studied, using a ligated loop model. Given intramuscularly at 5 mg/kg, CPZ induced a 50% increase of net fluid absorption in jejunum, but had no effect in
Publikováno v:
Acta Pharmacologica et Toxicologica. 49:190-194
Fractionation of the bile from rats injected with 65ZnCl2 (5 μmol/kg) showed that zinc was mainly bound to low molecular weight compounds eluted corresponding to the zinc-glutathione complexes. Diethylmaleate (3.9 mmol/kg), cyclohexene oxide (4.9 mm
Publikováno v:
Acta Pharmacologica et Toxicologica. 58:84-87
The distribution into cerebrospinal fluid (CSF) of five 3H- or 14C-labelled beta-adrenoceptor blocking drugs given intravenously was studied in urethane-anaesthetized rats. The doses (mg/kg) were: alprenolol 5, metoprolol 1, oxprenolol 5, pindolol 0.
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:12-15
Some of the cardiac properties of the partial beta-agonist prenalterol may indicate a contribution from alpha 1-adrenergic stimulation. We therefore studied whether prenalterol interacted with alpha 1-adrenoceptors in rat myocardium. Combination with
Publikováno v:
Acta Pharmacologica et Toxicologica. 55:303-307
A new antiarrhythmic drug, droxicainide, was compared with lidocaine in order to evaluate droxicainide's effect on heart muscle. Dose-response curves for electrophysiological and mechanical effects of the two drugs on spontaneously beating atria, ele