Zobrazeno 1 - 10
of 2 584
pro vyhledávání: ''
Publikováno v:
Journal of Pharmacy and Pharmacology. 70:1102-1112
ObjectivesInflammation plays an important role in the pathogenesis of diabetic nephropathy (DN). The aim of this study was to explore the anti-inflammatory role of PTY-2r (extracted from Pueraria tuberosa), on streptozotocin (STZ)-induced DN rats.Met
Autor:
Thea P. Lillethorup, Anna Sophie Thue Hvilsom, Anne M. Landau, Peter Iversen, Doris J. Doudet, Gregers Wegener
Publikováno v:
Hvilsom, A S T, Lillethorup, T P, Iversen, P, Doudet, D J, Wegener, G & Landau, A M 2019, ' Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli ', European Neuropsychopharmacology, vol. 29, no. 4, pp. 493-500 . https://doi.org/10.1016/j.euroneuro.2019.02.009
Depression is a debilitating mental illness and two thirds of patients respond insufficiently to conventional antidepressants. Electroconvulsive therapy (ECT) remains the most effective treatment to alleviate drug-refractory depression, however the n
Publikováno v:
Pharmacology Biochemistry and Behavior. 103:643-651
Major depression is a complex multi-factorial disorder with a lifetime diagnosis of nearly 1 out of 6. We used the Flinders Sensitive Line (FSL) of rats, a model of depression, and the parent Sprague-Dawley (SD) rats to identify genes, gene ontology
Fluphenazine decanoate (25 mg/kg IM every 3 weeks x 6) resulted in spontaneous vacuous chewing mouth movements and jaw tremor in male Sprague-Dawley rats. These movements could be suppressed by the selective D1 or D2 dopamine antagonists SCH 23390 (0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d883e2961ff1d3f8705a095f539a3d7c
https://ora.ox.ac.uk/objects/uuid:9f12da8e-5755-4fe8-82cb-ee78565a0f02
https://ora.ox.ac.uk/objects/uuid:9f12da8e-5755-4fe8-82cb-ee78565a0f02
The cannabinoid agonist, HU210 has been evaluated in vivo in nociceptive and inflammatory pain models in the rat. The ED50 for the anti-nociceptive (increasing mechanical withdrawal threshold) effect was 0.1 mg/kg-1 i.p., and for anti-hypersensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6635f2e7bd56ffc45835e029b97061b9
https://ora.ox.ac.uk/objects/uuid:4d0a190e-beb9-4796-a4b9-6211dd4616c5
https://ora.ox.ac.uk/objects/uuid:4d0a190e-beb9-4796-a4b9-6211dd4616c5
Rats were given continuous infusions of (+)-4-propyl-9-hydroxynaphthoxazine (PHNO, 5 micrograms/h), a dopamine D-2 receptor agonist, using subcutaneous implants of ALZET osmotic minipumps. It was observed that tolerance occurred to the motor stimulan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8bd8a97dabb6d04d7039f78f9a0262
https://doi.org/10.1016/0014-2999(88)90037-4
https://doi.org/10.1016/0014-2999(88)90037-4
Publikováno v:
Liebenberg, N, Harvey, B H, Brand, L, Wegener, G & Brink, C B 2012, ' Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats ', Metabolic Brain Disease, vol. 27, no. 3, pp. 337-340 . https://doi.org/10.1007/s11011-012-9284-z
There are conflicting results from behavioural studies regarding whether the activation or inhibition of the cGMP-nitric oxide (NO) pathway induces anxiolyticlike behaviour. Sildenafil, an inhibitor of cGMP-selective phosphodiesterase-5, increases an
Publikováno v:
Pharmacology Biochemistry and Behavior. 99:487-499
In rats, 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) causes anorexia that may lead to fatal wasting but has hitherto been poorly characterized. Therefore, we studied in-depth feeding and drinking behaviors of TCDD-sensitive L–E rats for 5 (100 μg
Autor:
Michelle A. Collins, Robert N. Hughes
Publikováno v:
Pharmacology Biochemistry and Behavior. 94:534-542
Middle-aged 330-day-old male and female hooded rats were group-housed for nearly 5 months in either standard cages, or in cages containing objects. Each cage also provided either pure water, or a solution of vitamin E (DL-alpha-tocopherol acetate) fo
Autor:
Ewen MacDonald
Publikováno v:
Acta Pharmacologica et Toxicologica. 54:76-80
The pithed rat preparation was used to study the effects of copper (as cupric chloride) on the release and re-uptake of noradrenaline from sympathetic nerves. At the highest concentration which could be tested without failure of the preparation, ther