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Autor:
Terrance P. Snutch, Changiz Taghibiglou, Sathiya Sekar, John G. Howland, Venkat Gopalakrishnan, Quentin Greba, Wendie N. Marks
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 47:1530-1536
Insulin-mediated signalling in the brain is critical for neuronal functioning. Insulin resistance is implicated in the development of some neurological diseases, although changes associated with absence epilepsy have not been established yet. Therefo
Publikováno v:
Journal of Pharmacy and Pharmacology. 70:1102-1112
ObjectivesInflammation plays an important role in the pathogenesis of diabetic nephropathy (DN). The aim of this study was to explore the anti-inflammatory role of PTY-2r (extracted from Pueraria tuberosa), on streptozotocin (STZ)-induced DN rats.Met
Autor:
Thea P. Lillethorup, Anna Sophie Thue Hvilsom, Anne M. Landau, Peter Iversen, Doris J. Doudet, Gregers Wegener
Publikováno v:
Hvilsom, A S T, Lillethorup, T P, Iversen, P, Doudet, D J, Wegener, G & Landau, A M 2019, ' Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli ', European Neuropsychopharmacology, vol. 29, no. 4, pp. 493-500 . https://doi.org/10.1016/j.euroneuro.2019.02.009
Depression is a debilitating mental illness and two thirds of patients respond insufficiently to conventional antidepressants. Electroconvulsive therapy (ECT) remains the most effective treatment to alleviate drug-refractory depression, however the n
Publikováno v:
Pharmacology Biochemistry and Behavior. 131:91-97
Background We have generated high- and low-nicotine preferring (high-NP, low-NP) rat lines using voluntary oral nicotine intake as the selection criterion. After nine generations, the estimated realized heritability for high intake was 0.26. The aim
The cannabinoid agonist, HU210 has been evaluated in vivo in nociceptive and inflammatory pain models in the rat. The ED50 for the anti-nociceptive (increasing mechanical withdrawal threshold) effect was 0.1 mg/kg-1 i.p., and for anti-hypersensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6635f2e7bd56ffc45835e029b97061b9
https://ora.ox.ac.uk/objects/uuid:4d0a190e-beb9-4796-a4b9-6211dd4616c5
https://ora.ox.ac.uk/objects/uuid:4d0a190e-beb9-4796-a4b9-6211dd4616c5
Rats were given continuous infusions of (+)-4-propyl-9-hydroxynaphthoxazine (PHNO, 5 micrograms/h), a dopamine D-2 receptor agonist, using subcutaneous implants of ALZET osmotic minipumps. It was observed that tolerance occurred to the motor stimulan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8bd8a97dabb6d04d7039f78f9a0262
https://doi.org/10.1016/0014-2999(88)90037-4
https://doi.org/10.1016/0014-2999(88)90037-4
Publikováno v:
Brain Research, 1398(8), 13-20. ELSEVIER SCIENCE BV
In the present research the role of gender in MDMA-induced hyperthermia and serotonin depletion is studied by injecting male and female male rats with MDMA or saline 3 times (i.p.) with 3 h interval at dosages of 0.3, 1, 3 or 9 mg/kg at an ambient te
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 38:143-162
The dynamics of aging and type 2 diabetes (T2D) disease progression were investigated in normal [Wistar-Kyoto (WKY)] and diabetic [Goto-Kakizaki (GK)] rats and a mechanistic disease progression model was developed for glucose, insulin, and glycosylat
Autor:
Michelle A. Collins, Robert N. Hughes
Publikováno v:
Pharmacology Biochemistry and Behavior. 94:534-542
Middle-aged 330-day-old male and female hooded rats were group-housed for nearly 5 months in either standard cages, or in cages containing objects. Each cage also provided either pure water, or a solution of vitamin E (DL-alpha-tocopherol acetate) fo
Autor:
Keld Kjeldsen, Aage Nørgaard
Publikováno v:
Acta Pharmacologica et Toxicologica. 58:363-367
Previous studies have shown an increase in 3H-ouabain binding sites or Na,K-pumps in vitro in cultured cells in response to incubation in low K, diuretics or lithium. However, in the present study the administration in vivo of various diuretics or li