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Publikováno v:
European Journal of Pharmacology. 218:199-203
The present study was undertaken to investigate the role of prostaglandins in the shortening of transit time observed after intraduodenal administration of rhein anthrone and rhein. After intraduodenal administration of rhein anthrone (0.5-10 mg/rat)
Autor:
Kanji Takada, Shozo Muranishi, Takayuki Douen, Masahiro Murakami, Minoru Hashizume, Akira Yamamoto
Publikováno v:
Journal of Pharmacy and Pharmacology. 44:555-559
The intestinal absorption of 125I-labelled palmitoyl insulin was examined following administration into in-situ closed large intestinal loops of rats. When mono- and dipalmitoyl insulins (Palins-1 and Palins-2, respectively) were administered in poly
Publikováno v:
Biochemical Pharmacology. 44:379-382
The antihyperlipidaemic agent benfluorex [1-(3-trifluoromethylphenyl)-2-(2-benzoyl-oxyethyl)-aminopropane] and its metabolite S422 [1-(3-trifluoromethylphenyl)-2-(2-hydroxyethyl)-aminopropane] were examined for an acute (after 1–2 hr) effect on glu
Publikováno v:
British Journal of Pharmacology. 106:628-631
1. A model has been developed to compare the inhibitory effects of the topical steroid, betamethasone-17-valerate, to those of systemically administered betamethasone upon oedema responses induced by 5-hydroxytryptamine (5-HT), platelet activating fa
Autor:
Rexford S. Ahima, Richard E. Harlan
Publikováno v:
Brain Research. 585:311-314
To determine whether androenic-anabolic steroids (AAS) regulate glucocorticoid receptors (GR), the effects of a mixture of three commonly abused AAS (testosterone cypionate, nandrolone decanoate and boldenone undecylenate) on GR immunoreactivity (ir)
Autor:
Helga Lejeune, Monique Soffie
Publikováno v:
Psychopharmacology. 106:215-220
The effects of central cholinergic blockade on the temporal regulation of behaviour were studied with a two-level DRL schedule. Five-month-old male Wistar rats had to press lever A and then wait for a minimum of 5 s before pressing lever B to obtain
Publikováno v:
European Neuropsychopharmacology. 2:115-120
Biochemical and behavioural experiments have indicated that the novel antidepressant tianeptine stimulates 5-hydroxytryptamine (5-HT) reuptake. The present study has explored the influence of acute tianeptine pretreatment upon corticosterone release
Autor:
David L. Wolgin, Jacqueline Moore
Publikováno v:
Psychopharmacology. 107:290-296
The purpose of this study was to determine the effect of manipulating the interdose interval (IDI) on the suppression of milk intake induced by haloperidol (HAL). Groups of rats were given chronic injections of either HAL (0.625 mg/kg) or saline at I
Autor:
Elsa M. Valdizán, Juan A. Armijo
Publikováno v:
Biochemical Pharmacology. 43:2143-2150
The effects of increasing (50–1600 mg/kg/day) doses of vigabatrin (GVG) both as single doses and after 8 or 28 days of treatment have been studied in 19 groups of 10 adult Wistar rats. The parameters studied were brain γ-aminobutyric acid-transami
Publikováno v:
European Journal of Pharmacology. 216:123-126
The effects of sodium orthovanadate (0.6 mg/ml in drinking water) on hexokinase isozymes, pyruvate kinase and malic enzyme in liver and kidney of control and alloxan diabetic rats were studied and compared. Vanadate treatment of diabetic rats normali