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Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 320:1216-1223
Streptozotocin (STZ)-induced diabetes can modulate dopamine (DA) neurotransmission and thereby modify the behavioral effects of drugs acting on DA systems. Insulin replacement, and in some conditions repeated treatment with amphetamine, can partially
Autor:
Karren M. Plain, Bruce M. Hall, Giang T. Tran, Rochelle Boyd, Nirupama D. Verma, Catherine M. Robinson
Publikováno v:
Transplantation. 82:1324-1333
Background Interleukin (IL)-12p70, a heterodimeric cytokine has been considered central to induction of Th1 responses with the assistance of IL-18 and IL-27. It was predicted IL-12p70 treatment would promote allograft rejection. In these studies, IL-
Publikováno v:
Cancer Biology & Therapy. 5:593-600
Currently, there are no available effective preventative or adjunctive agents to alleviate symptoms of chemotherapy-induced mucositis. This is compounded by the absence of a recognized and validated noninvasive biomarker to assess gut function. This
Publikováno v:
Psychopharmacology. 186:235-245
Rationale: Rats selectively bred for high saccharin (HiS) intake consume more alcohol, acquire intravenous (i.v.) cocaine self-administration more rapidly, and show more dysregulated patterns of cocaine self- administration than their low saccharin-c
Autor:
Bernard Descomps, Odair Alves Silva, Saad Lahlou, Gloria Pinto Duarte, Cristina de Oliveira Silva
Publikováno v:
Pharmaceutical biology. 53(4)
Elevated oxidative stress plays a key role in diabetes-associated vascular disease. Excessive production of reactive oxygen species via advanced glycation end products (AGEs) activates peroxisome proliferator-activated receptor gamma (PPARγ) and the
Autor:
Atsuhiro Sugidachi, Koichi Fujimoto, Junichiro Fukushige, Naoki Tanaka, Yoshiro Tani, Fumitoshi Asai, Taketoshi Ogawa
Publikováno v:
European Journal of Pharmacology. 521:156-163
The effects of R-102444 ((2R, 4R)-4-lauroyloxy-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-1-methylpyrrolidine hydrochloride) and its active metabolite R-96544 ((2R, 4R)-2-[2-[2-[2-(3-methoxy)phenyl]ethyl]phenoxy]ethyl-4-hydroxy-1-methylpyrrolid
Publikováno v:
Journal of Urology. 173:1395-1399
Purpose: We examined the effects of saw palmetto extract (SPE) on the rat micturition reflex and on autonomic receptors in the lower urinary tract. Materials and Methods: The effect of SPE was examined on cystometrograms of anesthetized rats induced
Autor:
Masahiro Iwaki, Hiroshi Komura
Publikováno v:
Journal of Pharmaceutical Sciences. 94:397-408
The purpose of this study was to clarify the pharmacokinetics of CYP2D6 substrates in female DA and Wistar rats, which are regarded as animal models of poor metabolizers and extensive metabolizers, respectively. In vivo pharmacokinetic and in vitro m
Autor:
Robert A. Kirken, Robert M. Langer, Ping Li, Brian Dupre, Lily Feng, Richard A.F. Dixon, Barry D. Kahan, H Podder, Mou-Er Wang, Rongxiang Han, Kurt L. Berens, Stanislaw M. Stepkowski, Wayne W. Hancock
Publikováno v:
Journal of the American Society of Nephrology. 15:2893-2901
Binding of the P-, L-, and E-selectins to sialyl Lewis(x) (sLe(x)) retards circulating leukocytes, thereby facilitating their attachment to the blood vessels of allografts. Whether the selectin inhibitor bimosiamose (BIMO; C(46)H(54)O(16) . 0.25 H(2)
Publikováno v:
Phytomedicine. 9:9-14
Extracts of leaves from the plant Stevia rebaudiana Bertoni have been used in the traditional treatment of diabetes in Paraguay and Brazil. Recently, we demonstrated a direct insulinotropic effect in isolated mouse islets and the clonal beta cell lin