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Autor:
Philip J. Cowen, Sarah E. Gartside
Serotonin has a facilitatory role in the role of prolactin and adrenocorticotropin (ACTH) secretion. The serotonin precursor 5-hydroxy-L-tryptophan (5-HTP) dose dependently (30-100 mg/kg i.p.) increased plasma prolactin and ACTH in the male rat. Prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83e0218062c2963aea6ec600950c4bc
https://doi.org/10.1016/0014-2999(90)90407-w
https://doi.org/10.1016/0014-2999(90)90407-w
The cannabinoid agonist, HU210 has been evaluated in vivo in nociceptive and inflammatory pain models in the rat. The ED50 for the anti-nociceptive (increasing mechanical withdrawal threshold) effect was 0.1 mg/kg-1 i.p., and for anti-hypersensitivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6635f2e7bd56ffc45835e029b97061b9
https://ora.ox.ac.uk/objects/uuid:4d0a190e-beb9-4796-a4b9-6211dd4616c5
https://ora.ox.ac.uk/objects/uuid:4d0a190e-beb9-4796-a4b9-6211dd4616c5
The effects of various manipulations of brain 5-HT mechanisms on the behavioural responses induced by the selective NK-3 tachykinin agonist senktide in rodents were assessed. Senktide elicited wet dog shakes in the rat which were attenuated by the 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bfccde08c7e4e4537e319e5d9d672d
https://doi.org/10.1016/0006-8993(90)91015-9
https://doi.org/10.1016/0006-8993(90)91015-9
Rats were given continuous infusions of (+)-4-propyl-9-hydroxynaphthoxazine (PHNO, 5 micrograms/h), a dopamine D-2 receptor agonist, using subcutaneous implants of ALZET osmotic minipumps. It was observed that tolerance occurred to the motor stimulan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8bd8a97dabb6d04d7039f78f9a0262
https://doi.org/10.1016/0014-2999(88)90037-4
https://doi.org/10.1016/0014-2999(88)90037-4
Publikováno v:
Liebenberg, N, Harvey, B H, Brand, L, Wegener, G & Brink, C B 2012, ' Chronic treatment with the phosphodiesterase type 5 inhibitors sildenafil and tadalafil display anxiolytic effects in Flinders Sensitive Line rats ', Metabolic Brain Disease, vol. 27, no. 3, pp. 337-340 . https://doi.org/10.1007/s11011-012-9284-z
There are conflicting results from behavioural studies regarding whether the activation or inhibition of the cGMP-nitric oxide (NO) pathway induces anxiolyticlike behaviour. Sildenafil, an inhibitor of cGMP-selective phosphodiesterase-5, increases an
Publikováno v:
Psychopharmacology. 214:941-947
The monoamine reuptake inhibitor sibutramine reduces food intake but the receptor subtypes mediating the effects of sibutramine on feeding remain to be clearly identified.The involvement of the 5-HT(2C) receptor subtype in the satiety-enhancing effec
Publikováno v:
Acta Pharmacologica et Toxicologica. 53:3-11
The partial beta-agonist prenalterol has been found to differ from the full agonist isoprenaline in some aspects of its cardiac action. We therefore studied in rat myocardium whether prenalterol elicited the same qualitative changes of the contractio
Publikováno v:
Acta Pharmacologica et Toxicologica. 51:309-320
Rats under pentobarbitone anaesthesia, pancuronium relaxation and artificial ventilation with constant volume, were given methacholine (MeCh) 4, 6, and 9 micrograms intravenously at 2 min. intervals; the rise in intratracheal pressure indicated bronc
Autor:
Erik Lassen
Publikováno v:
Acta Pharmacologica et Toxicologica. 56:273-277
Male Wistar rats received a single stomach load (10 ml/kg) of a 150 mmol LiCl solution, either alone or together with tetracycline (33.5 mg/10 ml), ampicillin (33.5 mg/10 ml), or metronidazole (15 mg/10 ml). Urine was collected 1-5 hours after admini
Autor:
Ulrich Tacke, Claus Bræstrup
Publikováno v:
Acta Pharmacologica et Toxicologica. 55:252-259
Benzodiazepine receptors were investigated in the cerebral cortex, the hippocampus, the brainstem, and the cerebellum of audiogenic seizure (AGS)-susceptible and seizure-resistant (ER) control rats. In AGS-susceptible rats of Sprague-Dawley descent,