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Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 345:639-646
Brain cortex slices were preincubated with 3H-noradrenaline and superfused with physiological salt solution containing desipramine. We studied the inhibition of the electrically evoked tritium overflow caused by histamine in the presence of α-adreno
Publikováno v:
Journal of Cardiovascular Pharmacology. 19:958-965
Isolated tail arteries from Wistar rats, prelabeled with [3H]norepinephrine (NE) were subjected to electrical field stimulation (24 pulses at 0.4 Hz and 200 mA). Both NE release and vasoconstriction were measured in parallel. The selective alpha 2-ad
Autor:
Sergio De Moraes, Antonio Carlos Bento
Publikováno v:
General Pharmacology: The Vascular System. 23:565-570
1. 1. Estrogen pretreatment increases the responsiveness to noradrenaline and to clonidine in isolated rat female aortae. 2. 2. Determinations of the pK A and pA 2 of noradrenaline and prazosin, respectively suggest that the isolated female aorta pos
Autor:
E. S. Vizi, L. G. Harsing
Publikováno v:
Journal of Pharmacy and Pharmacology. 44:231-234
Rat vas deferens was prepared, loaded with [3H]noradrenaline, and superfused to measure the release of tritium in resting conditions and in response to electrical field stimulation. The α2-adrenoceptor antagonists yohimbine, CH-38083 (7,8-(methylene
Publikováno v:
European Journal of Pharmacology. 211:257-261
Previous studies on spontaneously hypertensive rats (SHR) have yielded inconsistent information about functional aberrations of the presynaptic alpha 2- and beta 2-adrenoceptor-mediated modulation of sympathetic neurotransmitter release. In the prese
Publikováno v:
British Journal of Pharmacology. 105:297-304
1. The vascular activity of two stereoisomers of hepoxilin A3 (HxA3) (8R and 8S) and of its glutathione conjugate, hepoxilin A3-C (HxA3-C) (8R and 8S), was investigated on rat helicoidal strips of thoracic aorta and longitudinal strips of portal vein
Autor:
Martha Kim, Paula C. Bickford
Publikováno v:
Neuropharmacology. 31:77-83
The electrophysiological actions of phencyclidine (PCP) and the sigma agonist 1,3-di(2tolyl)guanidine (DTG) were examined in the cerebellum of urethane-anesthetized rats. The object of the study was to determine if PCP and sigma agonists shared a com
Publikováno v:
Psychopharmacology. 106:19-25
Clonidine is a clinically used antihypertensive which has been suggested to produce physiological changes in children after exposure in utero. The aim of our study was to test the hypothesis that chronic exposure of the developing brain to an alpha 2
Publikováno v:
Biochemical Pharmacology. 42:S121-S126
Agents that enhance gamma-aminobutyric acid (GABA) neurotransmission can modulate certain effects of opioids, such as analgesia. In this study, the interaction between morphine and GABAergic agents on the release of [3H]norepinephrine ([3H]NE) from r
Autor:
David J. McManus, Andrew J. Greenshaw, Darrell D. Mousseau, Thomas B. Wishart, Paul R. Paetsch
Publikováno v:
Biological Psychiatry. 30:1122-1130
Effects of chronic administration of antidepressant drugs on beta-adrenoceptor function were assessed. Tricyclics (imipramine 30 mg/kg/day, desipramine 5 and 10 mg/kg/day) and monoamine oxidase inhibitors [(+/-)-tranylcypromine 1 mg/kg/day, phenelzin