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of 16
pro vyhledávání: '"J Aitken"'
Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes
Autor:
Clare Megson, Anna E. Long, Isabel V. Wilson, F. Susan Wong, Rachel J Aitken, Stephanie J. Hanna, Kathleen M Gillespie, Joanne Boldison
Publikováno v:
Diabetologia
Boldison, J, Long, A E, Aitken, R J, Wilson, I V, Hanna, S, Wong, F S & Gillespie, K M 2022, ' Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes ', Diabetologia, vol. 65, no. 2, pp. 343-355 . https://doi.org/10.1007/s00125-021-05595-0
Boldison, J, Long, A E, Aitken, R J, Wilson, I V, Hanna, S, Wong, F S & Gillespie, K M 2022, ' Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes ', Diabetologia, vol. 65, no. 2, pp. 343-355 . https://doi.org/10.1007/s00125-021-05595-0
Aims/hypothesis Slow progressors to type 1 diabetes are individuals positive for multiple pancreatic islet autoantibodies who have remained diabetes-free for at least 10 years; regulation of the autoimmune response is understudied in this group. Here
Publikováno v:
Annals of Oncology. 21:1254-1261
Background Assessment of receptors [estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)] is routinely carried out on primary tumour in order to select appropriate adjuvant therapy; the same analysis
Autor:
Brendan E.L. Adams, Damian E. Myers, Mark A. Kirkland, Geoffrey C. Nicholson, C. J. Aitken, Carolina M. Lopez, Jason M. Hodge, Caryll M Waugh
Publikováno v:
Journal of Bone and Mineral Research. 19:190-199
Human osteoclasts can be efficiently generated in vitro from cord blood mononuclear cells and derived CFU-GM colonies. However, CFU-M colonies are poorly osteoclastogenic. Short-term (2–48 h) treatment with GM-CSF stimulates osteoclast formation by
Autor:
A. R. van der Slik, Geoffrey V. Gill, Stephen C. Bain, Kathleen M Gillespie, Rachel J Aitken, Bart O. Roep, Anna E. Long, KL Mehers, V Nathwani, Polly J. Bingley, Florence Susan Wong
Publikováno v:
Diabetologia, 54(12), 3062-3070
Natural killer (NK) cells serve as primary immune surveillance and are partially regulated by combinations of killer immunoglobulin-like receptor (KIR) genes and their HLA class I ligands. Alterations in NK cell activity have been associated with typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c309cb8082cdb84b634c4c0e557f56a8
http://hdl.handle.net/1887/110948
http://hdl.handle.net/1887/110948
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 77:1622-1628
C19 steroids are converted to estrogens in a number of tissues by a specific form of cytochrome P450, namely aromatase cytochrome P450 (P450arom). Adipose tissue is the principal site of estrogen formation in postmenopausal women. Aromatase activity
Publikováno v:
Archives of biochemistry and biophysics. 482(1-2)
Pharmacological modulators of beta-adrenoceptors can influence bone mineral density and fracture risk in humans. Studies reported that beta-adrenoceptor ligands stimulate bone resorption by enhancing the expression of RANK-L, whereas the mechanisms b
Autor:
R J Aitken
Publikováno v:
Ciba Foundation Symposium 64-Maternal Recognition of Pregnancy
The hormonal control of implantation in mammalian species with and without embryonic diapause is described. In a majority of species displaying the obligate form of diapause the corpora lutea appear to exhibit a low level of steroidogenic activity th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf6287d59d3f4c184b5e606198bcda6
https://doi.org/10.1002/9780470720479.ch4
https://doi.org/10.1002/9780470720479.ch4
Autor:
Karen J. Aitken, Gregory Block, Armando Lorenzo, Daniel Herz, Nesrin Sabha, Omar Dessouki, France Fung, Marta Szybowska, Laura Craig, Darius J. Bägli
Excessive wall stretch of distensible hollow organs in cardiovascular and urinary systems can activate matrix metalloproteinases (MMPs), thereby releasing matrix neoepitopes and growth factor ligands, leading to ERK1/2 activation. However, the role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531dee228e4aff5d92d2eec7cac2eca6
https://europepmc.org/articles/PMC1698787/
https://europepmc.org/articles/PMC1698787/
Summary A 58 year old man underwent a laparotomy for intestinal obstruction, which proved to be due to intestinal pseudo-obstruction. Following a slow postoperative course, he was discovered to have a gastric phytobezoar. The association between bezo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969a1e6bfbd30236f9af89b4442a5ca9
https://europepmc.org/articles/PMC2399698/
https://europepmc.org/articles/PMC2399698/
Autor:
R. J. Aitken, D. W. Richardson
Publikováno v:
Journal of Experimental Zoology. 216:149-158
Active immunization of rats with cross-reacting zona pellucida antigens derived from cumulus-free mouse ova resulted in the induction of infertility without adverse side effects. Half of the immunized animals never regained their fertility despite re