Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Margery A. Connelly"'
Autor:
Robin P. F. Dullaart, Margery A. Connelly, Stephan J. L. Bakker, B. D. Westenbrink, Dion Groothof, Adrian Post, Jose L. Flores-Guerrero, Eke G. Gruppen, Erwin Garcia, Eline H. van den Berg
Publikováno v:
European Journal of Clinical Investigation, 51(12):13627, 1-12. Wiley
Background Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent, paralleling the obesity epidemic. Ketone bodies are produced in the liver, but it is currently uncertain whether circulating ketone bodies are increased in the context of
Autor:
Erik Lipsic, B. Daan Westenbrink, Marie Sophie L.Y. de Koning, Pim van der Harst, Solmaz Assa, Dirk J. van Veldhuisen, Erwin Garcia, Robin P. F. Dullaart, Margery A. Connelly
Publikováno v:
Journal of the American College of Cardiology, 78(14), 1421-1432. ELSEVIER SCIENCE INC
Background: Circulating ketone bodies (KBs) are increased in patients with heart failure (HF), corresponding with increased cardiac KB metabolism and HF severity. However, the role of circulating KBs in ischemia/reperfusion remains unknown. Objective
Autor:
Adrian Post, Casper F. M. Franssen, Ido P. Kema, Stephan J. L. Bakker, Dion Groothof, J Casper Swarte, Erwin Garcia, Sara Sokooti, Robin P. F. Dullaart, Margery A. Connelly, Fabian A. Vogelpohl, Theo Wallimann, Daan Kremer
Publikováno v:
Journal of Hypertension, 40(2), 229-239. LIPPINCOTT WILLIAMS & WILKINS
Journal of Hypertension, 40 (2)
Journal of Hypertension
Journal of Hypertension, 40 (2)
Journal of Hypertension
Objective: Hypertension is a major risk factor for cardiovascular disease, kidney disease, and premature death. Increased levels of creatine kinase are associated with development of hypertension. However, it is unknown if creatine, a substrate of CK
Autor:
Ron T. Gansevoort, Jens H. J. Bos, Ido P. Kema, Stephan J. L. Bakker, Isidor Minović, Robin P. F. Dullaart, Margery A. Connelly, Rudolf A. de Boer, Daan J Touw, Eelko Hak, Lyanne M. Kieneker, Albert-jan Voerman, Manfred Eggersdorfer
Publikováno v:
Nutrients
Volume 12
Issue 9
Nutrients, Vol 12, Iss 2711, p 2711 (2020)
Nutrients, 12(9):2711, 1-17. MDPI AG
Volume 12
Issue 9
Nutrients, Vol 12, Iss 2711, p 2711 (2020)
Nutrients, 12(9):2711, 1-17. MDPI AG
Background: a large number of studies have linked vitamin B6 to inflammation and cardiovascular disease in the general population. However, it remains uncertain whether vitamin B6 is associated with cardiovascular outcome independent of inflammation.
Autor:
Eke G. Gruppen, Trynke van der Boom, Joop D. Lefrandt, Thera P. Links, Robin P. F. Dullaart, Margery A. Connelly
Publikováno v:
Scandinavian Journal of Clinical & Laboratory Investigation, 80(7), 562-566. Taylor & Francis Ltd
Branched chain amino acids (BCAA) are implicated in the pathogenesis of cardiometabolic diseases conceivably by affecting insulin resistance and mitochondrial dysfunction. Circulating BCAA levels may predict (subclinical) atherosclerosis, diabetes an
Autor:
Kavisha Singh, Eke G. Gruppen, Thomas Sperry, Salim S. Virani, Amit Khera, Christie M. Ballantyne, Alvin Chandra, Parag H. Joshi, Robin P. F. Dullaart, Margery A. Connelly, Anand Rohatgi, James D. Otvos, Colby Ayers
Publikováno v:
Circulation
Circulation, 142(7), 657-669. LIPPINCOTT WILLIAMS & WILKINS
Circulation, 142(7), 657-669. LIPPINCOTT WILLIAMS & WILKINS
Supplemental Digital Content is available in the text.
Background: High-density lipoprotein (HDL) cholesterol concentration (HDL-C) is an established atheroprotective marker, in particular for coronary artery disease; however, HDL particle conce
Background: High-density lipoprotein (HDL) cholesterol concentration (HDL-C) is an established atheroprotective marker, in particular for coronary artery disease; however, HDL particle conce
Autor:
Jose L. Flores-Guerrero, Robin P. F. Dullaart, Margery A. Connelly, Stephan J. L. Bakker, Hiddo J.L. Heerspink, Sara Sokooti
Publikováno v:
Cardiovascular Diabetology
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-14 (2021)
Cardiovascular Diabetology, 20(1):156. BioMed Central Ltd.
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-14 (2021)
Cardiovascular Diabetology, 20(1):156. BioMed Central Ltd.
Background Triglyceride-rich lipoproteins particles (TRLP) and low density lipoprotein particles (LDLP) vary in size. Their association with β-cell function is not well described. We determined associations of TRLP and LDLP subfractions with β-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f292df9bb9e075a2543fd0acdbd5fc
https://doi.org/10.21203/rs.3.rs-541933/v1
https://doi.org/10.21203/rs.3.rs-541933/v1
Autor:
B. D. Westenbrink, James D. Otvos, Robin P. F. Dullaart, Margery A. Connelly, Erwin Garcia, Jose L. Flores-Guerrero, Irina Shalaurova, Gerjan Navis, Stephan J. L. Bakker, Dion Groothof, Rudolf A. de Boer
Publikováno v:
European Journal of Clinical Investigation, 51(5):13468. Wiley
European Journal of Clinical Investigation
European Journal of Clinical Investigation
Background In the failing heart, energy metabolism is shifted towards increased ketone body oxidation. Nevertheless, the association of beta-hydroxybutyrate (beta-OHB) with development of heart failure (HF) remains unclear. We investigated the associ
Autor:
Robin P. F. Dullaart, Margery A. Connelly, Setor K Kunutsor, G. H. de Bock, Eke G. Gruppen, Stephan J. L. Bakker, Lyanne M. Kieneker, B. van der Vegt, Ron T. Gansevoort
Publikováno v:
Journal of Internal Medicine. Wiley
Gruppen, E G, Kunutsor, S K, Kieneker, L M, van der Vegt, B, Connelly, M A, de Bock, G H, Gansevoort, R T, Bakker, S J L & Dullaart, R P F 2019, ' GlycA, a novel pro-inflammatory glycoprotein biomarker is associated with mortality : results from the PREVEND study and meta-analysis ', Journal of Internal Medicine, vol. 286, no. 5, pp. 596-609 . https://doi.org/10.1111/joim.12953
Gruppen, E G, Kunutsor, S K, Kieneker, L M, van der Vegt, B, Connelly, M A, de Bock, G H, Gansevoort, R T, Bakker, S J L & Dullaart, R P F 2019, ' GlycA, a novel pro-inflammatory glycoprotein biomarker is associated with mortality : results from the PREVEND study and meta-analysis ', Journal of Internal Medicine, vol. 286, no. 5, pp. 596-609 . https://doi.org/10.1111/joim.12953
BACKGROUND: Chronic diseases are associated with an inflammatory response. We determined the association of two inflammatory markers, GlycA and high-sensitivity C-reactive protein (hsCRP), with overall and cause-specific mortality in a cohort of men
Autor:
Manal F. Abdelmalek, Margery A. Connelly, Stephen J. Rossi, Mary E. Rinella, Angelo H. Paredes, Stephen A. Harrison, Lei Ling, James F. Trotter, Mark J. Jaros, Alex M. DePaoli
Publikováno v:
Journal of Hepatology. 70:735-744
NGM282, an engineered analogue of the gut hormone FGF19, improves hepatic steatosis and fibrosis biomarkers in patients with non-alcoholic steatohepatitis (NASH). However, NGM282 increases serum cholesterol levels by inhibiting CYP7A1, which encodes