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Publikováno v:
European Journal of Pharmacology. 350:203-210
Probucol is an antihyperlipidemic agent with antioxidant effects and antiatherosclerotic properties in hypercholesterolemic conditions. The JCR:LA-corpulent strain of rats exhibits all aspects of the human 'metabolic syndrome' characterized by obesit
Autor:
A.B. Keith, A. Sahgal
Publikováno v:
Pharmacology Biochemistry and Behavior. 45:995-1001
Rats were trained on a delayed nonmatching to position task, divided into four groups and given the following lesions: (a) SHAM (vehicle injection into nucleus basilis magnocellularis (NBM) and raphe nuclei (RN), (b) RN (5,7-dihydroxytryptamine lesio
Publikováno v:
Psychopharmacology. 107:373-378
Nineteen rats received injections of 5,7-dihydroxytryptamine into the dorsal and median raphe nuclei; 16 rats received sham injections. The rats underwent 50 daily training sessions under an interresponse-time-greater-than-15-seconds (IRT greater tha
Publikováno v:
Europe PubMed Central
Alzheimer's Disease (AD) patients have a severe degeneration of cholinergic neurons in their cerebral cortices. Basal forebrain (BF)-lesioned rat is used as a model animal of a cholinergic deficit in the cerebral cortex. Cholinergic markers were decr
Autor:
Naohisa Fukuda, Tadatoshi Hashimoto
Publikováno v:
European Journal of Pharmacology. 203:25-32
The effect of treatment with thyrotropin-releasing hormone (TRH) or naloxone on the neurologic impairment after spinal cord injury was studied in rats with the severest neurologic impairment (complete paraplegia, no withdrawal response upon tail pinc
Publikováno v:
The American Journal of Medicine. 91:S2-S14
We have previously shown, using a gastric chamber model, that both sucralfate and luminal stasis protected the rat gastric mucosa against the development of hemorrhagic erosions produced by subsequent exposure for 10 minutes to acidified (50 mM HCl)
Publikováno v:
Clinical Neuropharmacology. 14:S1-S8
Data derived from a number of preclinical studies examining the effects of combined cholinergic and noradrenergic lesions in a rat model of Alzheimer's disease are reviewed. Results from these studies indicated that a nucleus basalis of Meynert (nbM)
Publikováno v:
British Journal of Pharmacology. 101:981-985
1. This study attempted to determine whether the activation of the tryptophan carrier in rat forebrain synaptosomes caused by depolarization or by extracellular sodium depletion occurred exclusively in 5-hydroxytryptaminergic nerve endings. 2. Ascend
Autor:
Yoshito Saitoh, Hiroshi Kawamura
Publikováno v:
Pharmacology Biochemistry and Behavior. 37:187-191
In male Wistar albino rats with chronically implanted electrodes, self-stimulation behavior was compared before and after making bilateral pontine lesions involving the subcoeruleus area and adjacent tegmental field. Before lesioning, slight suppress
Publikováno v:
Pharmacology Biochemistry and Behavior. 36:217-223
Rats were trained to rotate for a water reward using a procedure which required each rat to turn in both the left and right directions. The rats were then lesioned with unilateral injections of 6-hydroxydopamine in the nigrostriatal bundle to produce