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Publikováno v:
Neuropharmacology. 47:1-8
The effect of the group II metabotropic receptor agonist (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), on basal and phencyclidine-induced dopamine efflux were measured in the shell and core subdivisions of the nucleus accumbens-
Autor:
Balazs Sumegi, József L. Környei, Angéla Oszter, Marietta Vértes, Zsuzsanna Vértes, Ferenc Lengyel
Publikováno v:
Steroids. 69:263-270
Adult ovariectomized rats were implanted with [ d -Met2, Pro5]-enkephalinamide (ENK)-containing osmotic minipumps. Two hours prior to sacrifice, some animals were treated with estradiol-17β (E2) at a dose 10 μg/100 g bodyweight (BW). Expression and
Autor:
Sumio Shima
Publikováno v:
Pharmacology & Toxicology. 70:429-433
Effects of androgen treatment of young female rats on glucagon- and catecholamine-sensitive adenylate cyclase activity and adrenergic receptors of hepatic membranes have been studied. Injections of testosterone propionate for 7 days showed a signific
Publikováno v:
Psychopharmacology. 106:565-569
Male Sprague-Dawley rats were differentially housed for 21 days immediately after weaning. Isolated animals showed a selective suppression of exploration of the light side of a two compartment box; spending significantly less time in the light, and m
Autor:
Felipe Vilchis, Gustavo A. García, Ana E. Lemus, Ivonne Grillasca, B. Chávez, Rebeca Damsky, Gregorio Pérez-Palacios
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 41:881-890
Levonorgestrel (LNG) is a synthetic steroid that displays potent progestational and androgenic effects but it lacks estrogen-like activity. To examine the mode of action of this progestin, we studied its metabolism in vitro in target organs and the s
Publikováno v:
Neuropharmacology. 31:137-141
The effect of U-50,488H, a selective kappa opiate agonist, on tolerance-dependence and abstinence on the TRH receptors of the spinal cord and discrete regions of the brain of male Sprague-Dawley rats was determined. Rats were injected intraperitoneal
Publikováno v:
Brain Research. 571:313-322
The effects of chronic administration of selective dopaminergic agonists on D1 and D2 receptor density, affinity and function were measured in Sprague-Dawley rats. Animals received daily injections (i.p.) of the D1-selective agonist SKF-38393 (10 mg/
Publikováno v:
Neuropharmacology. 31:25-32
The 5-hydroxytryptamine1A (5-HT1A) receptor subtype seems to be of importance in the pathogenesis of depression and in the mode of action of antidepressants. In this study, behavioural experiments were performed in rats after oral administration of d
Autor:
M. L. Slevin, S. P. Joel, Pi I. Thompson, Lh H. Rees, N. Patel, Ashley B. Grossman, D. Hucks, Lorraine McLoughlin
Publikováno v:
British Journal of Cancer
The radiolabelled opioid receptor binding affinities of morphine and its active metabolite morphine 6-glucuronide at the total mu, mu 1, mu 2 and delta receptors were determined. Morphine 6-glucuronide was found to have a 4-fold lower affinity for th
Autor:
Jan M. Lundberg, Philippe Delay-Goyet
Publikováno v:
Biochemical and Biophysical Research Communications. 180:1342-1349
Summary Dactinomycin, a peptide antibiotic from Streptomyces spp., is a classical agent which inhibits DNA replication. In the present study, dactinomycin inhibited specific [ 125 I]NKA binding in rat colon membranes (K i = 1.05 × 10 −5 M) in a co