Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Judith E. Allen"'
Autor:
Christopher T. Dee, Andrew P. Badrock, Laurence Bugeon, Judith E. Allen, Leo A. H. Zeef, Margaret J. Dallman, Robert W. Lea, Adam Hurlstone, Federica Bottiglione, Madina Wane
Publikováno v:
The Journal of Immunology Author Choice
Bottiglione, F, Dee, C, Lea, R, Zeef, L, Badrock, A, Wane, M, Bugeon, L, Dallman, M J, Allen, J & Hurlstone, A 2020, ' Zebrafish IL-4-like cytokines and IL-10 suppress inflammation but only IL-10 is essential for gill homeostasis ', Journal of Immunology, vol. 205, no. 4, pp. 994-1008 . https://doi.org/10.4049/jimmunol.2000372
Bottiglione, F, Dee, C, Lea, R, Zeef, L, Badrock, A, Wane, M, Bugeon, L, Dallman, M J, Allen, J & Hurlstone, A 2020, ' Zebrafish IL-4-like cytokines and IL-10 suppress inflammation but only IL-10 is essential for gill homeostasis ', Journal of Immunology, vol. 205, no. 4, pp. 994-1008 . https://doi.org/10.4049/jimmunol.2000372
Key Points Zebrafish IL-4–like cytokines promote type 2 and suppress type 1 immunity. Zebrafish IL-10 is potently anti-inflammatory and essential for gill homeostasis.
Mucosal surfaces such as fish gills interface between the organism and the
Mucosal surfaces such as fish gills interface between the organism and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6775dac2b728a1827662b11149f578d
http://hdl.handle.net/10044/1/83214
http://hdl.handle.net/10044/1/83214
Autor:
Paul R. Giacomin, Lindsay A. Dent, Avril A. B. Robertson, Ramon M. Eichenberger, Andreas Kupz, David Brough, Jesuthas Ajendra, Zainab Agha, Judith E. Allen, Alex Loukas, Martha M Cooper, Rafid Alhallaf, Alistair L Chenery, Brian H. K. Chan, Tara E. Sutherland, James E Parkinson
Publikováno v:
Chenery, A L, Alhallaf, R, Agha, Z, Ajendra, J, Parkinson, J E, Cooper, M M, Chan, B H K, Eichenberger, R M, Dent, L A, Robertson, A A B, Kupz, A, Brough, D, Loukas, A, Sutherland, T E, Allen, J E & Giacomin, P R 2019, ' Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung ', Journal of Immunology, vol. 203, no. 10, pp. 2724-2734 . https://doi.org/10.4049/jimmunol.1900640, https://doi.org/10.4049/jimmunol.1900640
The Journal of Immunology Author Choice
The Journal of Immunology Author Choice
Key Points Nlrp3−/− mice have enhanced early antihelminth immunity in the lung. Type 2 immunity and repair responses are dysregulated in Nlrp3−/− mice. NLRP3 plays an inflammasome-independent role during Nippostrongylus infection.
Altern
Altern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc46a5bd8a37cd9add6e339d9604f5ad
https://doi.org/10.4049/jimmunol.1900640
https://doi.org/10.4049/jimmunol.1900640
Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths
Autor:
Mark S. Wilson, Lewis J. Entwistle, Manolis Gialitakis, Stephanie M. Coomes, Victoria S. Pelly, Dominik Rückerl, Frank Brombacher, Judith E. Allen, Jimena Perez-Lloret, Yashaswini Kannan, Stephanie Czieso, Isobel S. Okoye
Publikováno v:
Pelly, V S, Coomes, S M, Kannan, Y, Gialitakis, M, Entwistle, L J, Perez-Lloret, J, Czieso, S, Okoye, I S, Ruckerl, D, Allen, J, Brombacher, F & Wilson, M S 2017, ' Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths ', Journal of Experimental Medicine, vol. 214, no. 6, pp. 1809-1826 . https://doi.org/10.1084/jem.20161104
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Pelly et al. use novel mouse reporter systems to show that a proportion of Th2 cells develop from Foxp3-expressing cells in an IL-4–dependent manner, highlighting the potential to subvert T reg cell–mediated suppression in favor of type 2 immunit
Autor:
David A. Hume, Sheelagh Duncan, Frank Brombacher, Rick M. Maizels, Stephen J. Jenkins, Judith E. Allen, James P. Hewitson, Dominik Rückerl, Graham D. Thomas
Publikováno v:
The Journal of Experimental Medicine
Jenkins, S J, Ruckerl, D, Thomas, G D, Hewitson, J P, Duncan, S, Brombacher, F, Maizels, R M, Hume, D A & Allen, J E 2013, ' IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1 ', Journal of Experimental Medicine, vol. 210, no. 11, pp. 2477-2491 . https://doi.org/10.1084/jem.20121999
Jenkins, S J, Ruckerl, D, Thomas, G D, Hewitson, J P, Duncan, S, Brombacher, F, Maizels, R M, Hume, D A & Allen, J E 2013, ' IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1 ', Journal of Experimental Medicine, vol. 210, no. 11, pp. 2477-2491 . https://doi.org/10.1084/jem.20121999
IL-4 and CSF-1 both contribute to macrophage proliferation during nematode infection, but IL-4 permits increased tissue macrophage density without the coincident monocyte infiltration associated with elevated CSF-1 levels.
Macrophages (MΦs) col
Macrophages (MΦs) col
Autor:
Paula I, Seoane, Dominik, Rückerl, Cecilia, Casaravilla, Anabella A, Barrios, Álvaro, Pittini, Andrew S, MacDonald, Judith E, Allen, Alvaro, Díaz
Publikováno v:
Scientific Reports
Proliferation of macrophages is a hallmark of inflammation in many type 2 settings including helminth infections. The cellular expansion is driven by the type 2 cytokine interleukin-4 (IL-4), as well as by M-CSF, which also controls homeostatic level
Autor:
Attila Horvath, Judith E. Allen, Quang Minh Doan-Xuan, Zsolt Czimmerer, Mate Kiss, Gergely Nagy, Laszlo Nagy, Zsuzsanna S. Nagy, Cesaré Ovando Vázquez, Bence Daniel, Éva Várallyay, Sudhir Gopal Tattikota, Matthew N. Poy, Tamas Varga, Dominik Rückerl, Cei Abreu-Goodger, Zsolt Bacsó, Szilárd Póliska, Xin Yan
Publikováno v:
Genome Medicine
Czimmerer, Z, Varga, T, Kiss, M, Vázquez, C O, Doan-Xuan, Q M, Ruckerl, D, Tattikota, S G, Yan, X, Nagy, Z S, Daniel, B, Poliska, S, Horvath, A, Nagy, G, Varallyay, E, Poy, M N, Allen, J, Bacso, Z, Abreu-Goodger, C & Nagy, L 2016, ' The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p ', Genome Medicine, vol. 8, 63 . https://doi.org/10.1186/s13073-016-0315-y
Czimmerer, Z, Varga, T, Kiss, M, Vázquez, C O, Doan-Xuan, Q M, Rückerl, D, Tattikota, S G, Yan, X, Nagy, Z S, Daniel, B, Poliska, S, Horvath, A, Nagy, G, Varallyay, E, Poy, M N, Allen, J E, Bacso, Z, Abreu-Goodger, C & Nagy, L 2016, ' The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p ', Genome Medicine, vol. 8, no. 63, 63 . https://doi.org/10.1186/s13073-016-0315-y
Czimmerer, Z, Varga, T, Kiss, M, Vázquez, C O, Doan-Xuan, Q M, Ruckerl, D, Tattikota, S G, Yan, X, Nagy, Z S, Daniel, B, Poliska, S, Horvath, A, Nagy, G, Varallyay, E, Poy, M N, Allen, J, Bacso, Z, Abreu-Goodger, C & Nagy, L 2016, ' The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p ', Genome Medicine, vol. 8, 63 . https://doi.org/10.1186/s13073-016-0315-y
Czimmerer, Z, Varga, T, Kiss, M, Vázquez, C O, Doan-Xuan, Q M, Rückerl, D, Tattikota, S G, Yan, X, Nagy, Z S, Daniel, B, Poliska, S, Horvath, A, Nagy, G, Varallyay, E, Poy, M N, Allen, J E, Bacso, Z, Abreu-Goodger, C & Nagy, L 2016, ' The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p ', Genome Medicine, vol. 8, no. 63, 63 . https://doi.org/10.1186/s13073-016-0315-y
Background IL-4-driven alternative macrophage activation and proliferation are characteristic features of both antihelminthic immune responses and wound healing in contrast to classical macrophage activation, which primarily occurs during inflammator
Autor:
Lucy H. Jones, Stephen J. Jenkins, Judith E. Allen, Nico van Rooijen, Peter C. Cook, Andrew S. MacDonald, Dominik Rückerl, Fred D. Finkelman
Publikováno v:
Jenkins, S J, Ruckerl, D, Cook, P C, Jones, L H, Finkelman, F D, van Rooijen, N, MacDonald, A S & Allen, J E 2011, ' Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of T(H)2 Inflammation ', Science, vol. 332, no. 6035, pp. 1284-1288 . https://doi.org/10.1126/science.1204351
Science, 332(6035), 1284-1288. American Association for the Advancement of Science
Science, 332(6035), 1284-1288. American Association for the Advancement of Science
A defining feature of inflammation is the accumulation of innate immune cells in the tissue that are thought to be recruited from the blood. We reveal that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in o
Autor:
Judith E. Allen, Robert N. Barker, Andrew J. Rees, Heather M. Wilson, Dominik Rückerl, Silvia Gaspar-Pereira, Claire S. Whyte, E. T. Bishop
Publikováno v:
Journal of Leukocyte Biology. 90:845-854
Macrophages become activated by their environment and develop polarized functions: classically activated (M1) macrophages eliminate pathogens but can cause tissue injury, whereas alternatively activated (M2) macrophages promote healing and repair. Me
Publikováno v:
Medical Microbiology and Immunology. 192:33-40
Mice exposed intraperitoneally to either adult or first larval stage (microfilaria) of the human nematode parasite Brugia malayi display polarized cytokine responses. We have used this model to investigate the impact of altered cytokine profiles on i
Autor:
Herbert W. Virgin, Aubrey Bailey, Dmytro Kobuley, Frederic D. Bushman, Alice Laughlin, E. John Wherry, Tara E. Sutherland, Jean-Luc Boucher, Kyle Bittinger, David Artis, Vesselin T. Tomov, Sara Tran, Lisa C. Osborne, Matthew R. Hepworth, Laurel A. Monticelli, Mark C. Siracusa, Timothy J. Nice, Judith E. Allen
Parasites make it hard to fight viruses Microbial co-infections challenge the immune system—different pathogens often require different flavors of immune responses for their elimination or containment (see the Perspective by Maizels and Gause). Two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a73879283e74cf03cc8abba1a88f73a
https://europepmc.org/articles/PMC4548887/
https://europepmc.org/articles/PMC4548887/