Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leiliang Zhang"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Rift Valley fever (RVF) is a zoonotic disease caused by Rift Valley fever virus (RVFV), an emerging arbovirus within the Phenuiviridae family of Bunyavirales that has potential to cause severe diseases in both humans and livestock. It increases the i
Externí odkaz:
https://doaj.org/article/712bbe1bb0244c1aa0f9e085e02cca89
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Alphaviruses contain many human and animal pathogens, such as CHIKV, SINV, and VEEV. Accumulating evidence indicates that innate immunity plays an important role in response to alphaviruses infection. In parallel, alphaviruses have evolved many strat
Externí odkaz:
https://doaj.org/article/e30cabb67ebe4f22ac576189c18a9590
Autor:
Cheng-Feng Qin, Dongrong Yi, Jing An, Leiliang Zhang, Fengwen Xu, Yongxin Zhang, Jinming Zhou, Zhenlong Liu, Fei Guo, Kavita Raniga, Shan Cen, Xiaoyu Li, Ni An, Chen Liang, Jing Wang, Quanjie Li, Rui Zhou
Publikováno v:
Journal of Virology. 93
Type I interferon (IFN) inhibits viruses by inducing the expression of antiviral proteins. The IFN-induced myxovirus resistance B (MxB) protein has been reported to inhibit a limited number of viruses, including HIV-1 and herpesviruses, but its antiv
Autor:
Raymond T. Chung, Dahlene N. Fusco, Wenyu Lin, Du Cheng, Hong Zhao, Esperance A. Schaefer, Kaku Goto, Niwat Maneekarn, Amornrat O'Brien, Pattranuch Chusri, Lee F. Peng, Lei Zhao, Kattareeya Kumthip, Chansom Pantip, Satawat Thongsawat, Nikolaus Jilg, Leiliang Zhang
Publikováno v:
Journal of Virology. 86:8581-8591
Responses to alpha interferon (IFN-α)-based treatment are dependent on both host and viral factors and vary markedly among patients infected with different hepatitis C virus (HCV) genotypes (GTs). Patients infected with GT3 viruses consistently resp
Autor:
Nikolaus Jilg, Run-Xuan Shao, Raymond T. Chung, Hong Zhao, Wen-Chi Chen, Wenyu Lin, Kaku Goto, Lee F. Peng, Leiliang Zhang, Dahlene N. Fusco
Publikováno v:
Journal of Hepatology. 55:289-298
Background & Aims The combination of pegylated interferon (IFN) α and ribavirin (RBV) is the standard therapy for patients with chronic HCV infection. However, it produces a sustained virologic response (SVR) in only half of the treated individuals
Autor:
Wei-Lun Tsai, Raymond T. Chung, Lee F. Peng, Run-Xuan Shao, Eileen Sun, Woo Jin Chung, Leiliang Zhang, Guibenson Hyppolite, Jae Yong Jang
Publikováno v:
Journal of Virology. 84:6060-6069
We and others have observed that hepatic levels of suppressor of cytokine signaling 3 (SOCS3) are significantly higher in persons with chronic hepatitis C, particularly those who are nonresponders to interferon (IFN) treatment, than in healthy indivi
Autor:
S. Chung, Stevan A. Gonzalez, Maria Isabel Fiel, C. Zhang, Leiliang Zhang, Andrew H. Talal, Ira M. Jacobson
Publikováno v:
Journal of Viral Hepatitis. 15:331-338
Although epidemiologic studies have documented that hepatitis C virus (HCV)/human immunodeficiency virus (HIV) co-infected patients have accelerated fibrogenesis, especially those with CD4+ cell counts
Autor:
Wenyu Lin, Cynthia Brisac, Lee F. Peng, Sinu P. John, Raymond T. Chung, Yi Wen Huang, Hong Zhao, Abraham L. Brass, Stephane Chevaliez, Daniel Wambua, Dahlene N. Fusco, Christopher R. Chin, Tiao Xie, Leiliang Zhang, Nikolaus Jilg
Background & Aims Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disease. Interferon-α (IFNα) is an important component of anti-HCV therapy; it up-regulates transcription of IFN-stimulated genes, many of which have been inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5604b36bb12765982dc1c7486185ae96
https://europepmc.org/articles/PMC3665646/
https://europepmc.org/articles/PMC3665646/
Autor:
Dahlene N. Fusco, Zhi Hong, Raymond T. Chung, Du Cheng, Leiliang Zhang, Nikolaus Jilg, Wen-Chi Chen, Kaku Goto, Lee F. Peng, Kattareeya Kumthip, Run-Xuan Shao
Publikováno v:
Antiviral research. 97(2)
Suppressor of cytokine signaling 1 (SOCS1) and suppressor of cytokine signaling 3 (SOCS3) have been thought to block type I interferon (IFN) signaling. We have previously reported that SOCS3 suppresses HCV replication in an mTOR-dependent manner. How
Autor:
Kattareeya Kumthip, Dahlene N. Fusco, Du Cheng, Lee F. Peng, Raymond T. Chung, Oliver Hofmann, Winston Hide, Wenyu Lin, Kaku Goto, Leiliang Zhang, Andrew W. Tai, Nikolaus Jilg, Hong Zhao, Jae Young Jang
Background & Aims The precise mechanisms by which IFN exerts its antiviral effect against HCV have not yet been elucidated. We sought to identify host genes that mediate the antiviral effect of IFN-α by conducting a whole-genome siRNA library screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff590a3053eacc03c1b7484b58c64300
https://europepmc.org/articles/PMC3261326/
https://europepmc.org/articles/PMC3261326/