Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Guangxun Meng"'
Autor:
Lei Xiao, Quanjun Zhang, Zhenpeng Zhuang, Liangxue Lai, Han Wu, Meng Lian, Yihui Chen, Yu Zhao, Qin Jin, Zhaoming Liu, Yingying Li, Zhen Ouyang, Longquan Quan, Lei Li, Yinghua Ye, Yuan Liao, Kepin Wang, Guangxun Meng, Lei Shi, Wenjing Li, Hai Wang, Weikai Ge
Publikováno v:
The Journal of Immunology. 205:2532-2544
The NLRP3 inflammasome is associated with a variety of human diseases, including cryopyrin-associated periodic syndrome (CAPS). CAPS is a dominantly inherited disease with NLRP3 missense mutations. Currently, most studies on the NLRP3-inflammasome ha
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Frontiers in Immunology
Frontiers in Immunology
ObjectiveTo explore the role of the Nlrp3 inflammasome activation in the development of hemolytic uremic syndrome (HUS) induced by Stx2 and evaluate the efficacy of small molecule Nlrp3 inhibitors in preventing the HUS.MethodsPeritoneal macrophages (
Autor:
Qiuhong Guo, Guiwen Yang, Guangxun Meng, Guang Xue, Xiaomin Yao, Liguo An, Yue Xing, Hua Li, Yan Zhang
Publikováno v:
The Journal of Immunology. 199:1561-1566
NLRP3 inflammasome activiation requires two sequential signals. The priming signal 1 from TLRs or cytokine receptors induces the transcription of NLRP3 and IL-1β, and concomitantly promotes transcription-independent activation of caspase-1. The acti
Autor:
Boyin Qin, Yanling Feng, Xiaonan Ren, Yuqin Yang, Shuxian Wu, Rongrong Ren, Jialin Cai, Zhigang Song, Yunwen Hu, Lixiang Chen, Xiaohui Zhou, Di Tian, Guangxun Meng, Hua Yang, Chunhua Xu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
The avian origin influenza A virus (IAV) H7N9 has caused a considerable number of human infections associated with high rates of death since its emergence in 2013. As a vital component of the host innate immune system, the nucleotide-binding domain l
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 36, Iss 1, Pp 1-14 (2017)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
5-Fluorouracil (5-FU) is a widely used drug for the therapy of cancer. However, the chemoresistance of tumor cells to 5-FU usually limits its clinical effectiveness. In this study, we explored the role of NLRP3 inflammasome in 5-FU resistance of oral
Autor:
Yubin Li, Jingyun Luan, Guangxun Meng, Mingkuan Chen, Jiajun Fan, Wei Chen, Shaofei Wang, Dianwen Ju, Xuyao Zhang, Wenjing Zai, Yichen Wang, Sijia Wang
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Frontiers in Immunology
Autoimmune hepatitis (AIH) is a progressive inflammatory disorders of unknown etiology, characterized by immune-mediated destruction of hepatocytes and massive production of cytokines. Interleukin-1β is a pleiotropic proinflammatory cytokine and wel
Autor:
Yue Xing, Xiaoming Zhang, Yingxin Hu, Guang Xue, Guojun Wu, Qiuhong Guo, Benhua Zeng, Chenhong Zhang, Ailing Lu, Qianpeng Zhang, Fengwei Pan, Zhigang Tian, Liping Zhao, Rongbin Zhou, Warren Strober, Guangxun Meng, Hong Wei, Xiaomin Yao
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications
Inflammasomes are involved in gut homeostasis and inflammatory pathologies, but the role of NLRP3 inflammasome in these processes is not well understood. Cryopyrin-associated periodic syndrome (CAPS) patients with NLRP3 mutations have autoinflammatio
Activation of NLRP3 Inflammasome by Advanced Glycation End Products Promotes Pancreatic Islet Damage
Autor:
Qing Su, Ailing Lu, Hongmei Zhang, Xiang Kong, Li Qin, Xin-ming Yao, Guangxun Meng, Xiaoyong Li, Qiang Hua
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Accumulation of advanced glycation end products (AGEs) contributes to ageing and age-related diseases, especially type 2 diabetes. The NLRP3 inflammasome, as a vital component of the innate immune system, is implicated in the pathogenesis of type 2 d
Autor:
Hongbin Wang, Junling Niu, Qibin Leng, Li-Ping Zhu, Liming Mao, Wei Chen, Cunshuan Xu, Mingkuan Chen, Guowei Lei, Hua Li, Ailing Lu, Bin Xu, Guiwen Yang, Shuxian Wu, Guangxun Meng, Liguo An
Publikováno v:
Cell Research. 23:965-968
Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome
Autor:
Shuzhen Chen, Guangxun Meng, Shuhui Sun, Mingkuan Chen, Chang Chen, Warren Strober, Xiaodong Wu, Yan Zeng, Jing Li, Xiangrui Wang, Bing Sun, Zhengyu He, Kairui Mao, Yonglei Ma, Yan Wang, Yu Hu, Bo Huang
Publikováno v:
Cell Research
Inflammasomes are multi-protein complexes that trigger the activation of caspase-1 and the maturation of interleukin-1β (IL-1β), yet the regulation of these complexes remains poorly characterized. Here we show that nitric oxide (NO) inhibited the N