Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Kadowaki, T"'
Autor:
Takeuchi T; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Kubota T; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. kubota@oha.toho-u.ac.jp.; Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kawasaki, Japan. kubota@oha.toho-u.ac.jp.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. kubota@oha.toho-u.ac.jp.; Division of Diabetes and Metabolism, The Institute for Medical Science Asahi Life Foundation, Tokyo, Japan. kubota@oha.toho-u.ac.jp.; Department of Clinical Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Tokyo, Japan. kubota@oha.toho-u.ac.jp., Nakanishi Y; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kawasaki, Japan., Tsugawa H; Metabolome Informatics Research Team, RIKEN Center for Sustainable Resource Science (CSRS), Yokohama, Japan.; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.; Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Japan., Suda W; Laboratory for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Kwon AT; Laboratory for Applied Regulatory Genomics Network Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Yazaki J; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Ikeda K; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan., Nemoto S; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Mochizuki Y; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Kitami T; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Yugi K; Laboratory for Integrated Cellular Systems, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Institute for Advanced Biosciences, Keio University, Fujisawa, Japan.; Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan., Mizuno Y; Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.; Development Bank of Japan, Tokyo, Japan., Yamamichi N; Center for Epidemiology and Preventive Medicine, The University of Tokyo Hospital, Tokyo, Japan., Yamazaki T; International University of Health and Welfare, Tokyo, Japan., Takamoto I; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Metabolism and Endocrinology, Tokyo Medical University Ibaraki Medical Center, Ami Town, Japan., Kubota N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Toranomon Hospital, Tokyo, Japan., Arner E; Laboratory for Applied Regulatory Genomics Network Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Carninci P; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Fondazione Human Technopole, Milan, Italy., Ohara O; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan., Arita M; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan.; Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.; Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.; Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q), Keio University, Tokyo, Japan., Hattori M; Laboratory for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Koyasu S; Laboratory for Immune Cell Systems, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan., Ohno H; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. hiroshi.ohno@riken.jp.; Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kawasaki, Japan. hiroshi.ohno@riken.jp.; Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan. hiroshi.ohno@riken.jp.
Publikováno v:
Nature [Nature] 2023 Sep; Vol. 621 (7978), pp. 389-395. Date of Electronic Publication: 2023 Aug 30.
Autor:
Sasako T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan., Umehara T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Soeda K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan., Kaneko K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Suzuki M; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kobayashi N; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan., Okazaki Y; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Tamura-Nakano M; Communal Laboratory, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Chiba T; Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan., Accili D; Columbia University College of Physicians & Surgeons, Department of Medicine, New York, NY, USA., Kahn CR; Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA., Noda T; Department of Cell Biology, Cancer Institute, Japanese Foundation of Cancer Research, Tokyo, Japan., Asahara H; Department of Systems BioMedicine, Tokyo Medical and Dental University, Tokyo, Japan., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. t-kadowaki@toranomon.kkr.or.jp.; Toranomon Hospital, Tokyo, Japan. t-kadowaki@toranomon.kkr.or.jp., Ueki K; Department of Molecular Diabetic Medicine, Diabetes Research Center, National Center for Global Health and Medicine, Tokyo, Japan. uekik@ri.ncgm.go.jp.; Department of Molecular Diabetetology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. uekik@ri.ncgm.go.jp.
Publikováno v:
Nature communications [Nat Commun] 2022 Oct 05; Vol. 13 (1), pp. 5655. Date of Electronic Publication: 2022 Oct 05.
Autor:
Hayashi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Clinical Nutrition, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Tokyo, Japan., Kubota T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Clinical Nutrition, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Tokyo, Japan.; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Division of Diabetes and Metabolism, The Institute of Medical Science, Asahi Life Foundation, Tokyo, Japan.; Division of Cardiovascular Medicine, Toho University, Ohashi Hospital, Tokyo, Japan., Mariko I; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Clinical Nutrition, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Tokyo, Japan., Takamoto I; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Aihara M; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Sakurai Y; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Wada N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Clinical Nutrition, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Tokyo, Japan., Miki T; Department of Medical Physiology, Chiba University, Graduate School of Medicine, Chiba, Japan., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kubota N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan kadowaki-3im@h.u-tokyo.ac.jp nkubota-tky@umin.ac.jp.; Department of Clinical Nutrition, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Tokyo, Japan.; Department of Clinical Nutrition Therapy, The University of Tokyo, Tokyo, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan kadowaki-3im@h.u-tokyo.ac.jp nkubota-tky@umin.ac.jp.; Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Publikováno v:
Diabetes [Diabetes] 2021 Aug; Vol. 70 (8), pp. 1640-1653. Date of Electronic Publication: 2021 May 12.
Autor:
Iwabu M; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.; PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.; Laboratory for Advanced Research on Pathophysiology of Metabolic Diseases, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Okada-Iwabu M; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. omiki-tky@umin.ac.jp.; Laboratory for Advanced Research on Pathophysiology of Metabolic Diseases, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. omiki-tky@umin.ac.jp., Tanabe H; RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.; RIKEN Cluster for Science, Technology and Innovation Hub, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan., Ohuchi N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Miyata K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Kobori T; Division of Diabetes and Metabolism, The Institute for Adult Diseases, Asahi Life Foundation, 2-2-6 Nihonbashibakuro-cho, Chuo-ku, Tokyo, 103-0002, Japan., Odawara S; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Kadowaki Y; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Yokoyama S; RIKEN Structural Biology Laboratory, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan.; RIKEN Cluster for Science, Technology and Innovation Hub, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Japan., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. tyamau-tky@umin.ac.jp.; AMED-CREST, Japan Agency for Medical Research and Development, 1-7-1 Otemachi, Chiyoda-ku, Tokyo, 100-0004, Japan. tyamau-tky@umin.ac.jp., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. t-kadowaki@toranomon.kkr.or.jp.; Department of Prevention of Diabetes and Life-style Related Diseases, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. t-kadowaki@toranomon.kkr.or.jp.; Department of Metabolism and Nutrition, Mizonokuchi Hospital, Faculty of Medicine, Teikyo University, 5-1-1 Futago, Takatsu-ku, Kawasaki, Kanagawa, 213-8507, Japan. t-kadowaki@toranomon.kkr.or.jp.; Toranomon hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-8470, Japan. t-kadowaki@toranomon.kkr.or.jp.
Publikováno v:
Communications biology [Commun Biol] 2021 Jan 08; Vol. 4 (1), pp. 45. Date of Electronic Publication: 2021 Jan 08.
Autor:
Hosoe J; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Miya F; Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; CREST, JST, Tokyo, Japan., Kadowaki H; Department of Pediatrics, Sanno Hospital, Tokyo, Japan., Fujiwara T; Database Center for Life Science, Joint Support-Center for Data Science Research, Research Organization of Information and Systems, Chiba, Japan., Suzuki K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan., Kato T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Waki H; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Sasako T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Aizu K; Division of Endocrinology and Metabolism, Saitama Children's Medical Center, Saitama, Japan., Yamamura N; Department of Pediatric Nephrology and Metabolism, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan., Sasaki F; Department of Pediatrics, School of Medicine, Fukuoka University, Fukuoka, Japan., Kurano M; Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Hara K; Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, Saitama, Japan., Tanaka M; Institute of Medical Genomics, International University of Health and Welfare, Chiba, Japan., Ishiura H; Department of Neurology, The University of Tokyo Hospital, Tokyo, Japan., Tsuji S; Department of Molecular Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Honda K; Division of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan., Yoshimura J; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Morishita S; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Matsuzawa F; Tokyo R&D Center, Altif Laboratories, Inc., Tokyo, Japan., Aikawa SI; Tokyo R&D Center, Altif Laboratories, Inc., Tokyo, Japan., Boroevich KA; Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Nangaku M; Division of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan., Tsunoda T; Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; CREST, JST, Tokyo, Japan; Laboratory for Medical Science Mathematics, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan., Shojima N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: nshojima-tky@umin.ac.jp., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: tyamau-tky@umin.net., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Toranomon Hospital, Tokyo, Japan. Electronic address: t-kadowaki@toranomon.kkr.or.jp.
Publikováno v:
Diabetes research and clinical practice [Diabetes Res Clin Pract] 2020 Nov; Vol. 169, pp. 108461. Date of Electronic Publication: 2020 Sep 22.
Autor:
Hirota Y; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan., Suwanai H; Department of Diabetes, Metabolism and Endocrinology, Tokyo Medical University, Tokyo 160-0023, Japan., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Department of Metabolism and Nutrition, Mizonokuchi Hospital, Teikyo University, Kanagawa 213-8507, Japan.
Publikováno v:
Journal of diabetes research [J Diabetes Res] 2020 Apr 04; Vol. 2020, pp. 4359787. Date of Electronic Publication: 2020 Apr 04 (Print Publication: 2020).
Autor:
Wakabayashi T; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.; Department of Innovative Dementia Prevention, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan., Yamaguchi K; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Matsui K; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Sano T; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Kubota T; Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Kanagawa, 230-0045, Japan., Hashimoto T; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.; Department of Innovative Dementia Prevention, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan., Mano A; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Yamada K; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Matsuo Y; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan., Kubota N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.; Department of Clinical Nutrition Therapy, The University of Tokyo, Tokyo, 113-8655, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.; Department of Prevention of Diabetes and Lifestyle-Related Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.; Department of Metabolism and Nutrition, Mizonokuchi Hospital, Faculty of Medicine, Teikyo University, Tokyo, 213-8507, Japan., Iwatsubo T; Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. iwatsubo@m.u-tokyo.ac.jp.
Publikováno v:
Molecular neurodegeneration [Mol Neurodegener] 2019 Apr 12; Vol. 14 (1), pp. 15. Date of Electronic Publication: 2019 Apr 12.
Autor:
Hosoe J; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Kadowaki H; Department of Pediatrics, Sanno Hospital, Tokyo, Japan., Miya F; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.; Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan., Aizu K; Division of Endocrinology and Metabolism, Saitama Children's Medical Center, Saitama, Japan., Kawamura T; Department of Pediatrics, Osaka City University Graduate School of Medicine, Osaka, Japan., Miyata I; Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan., Satomura K; Department of Pediatric Nephrology and Metabolism, Osaka Women's and Children's Hospital, Osaka, Japan., Ito T; Department of Pediatrics, Atsugi City Hospital, Kanagawa, Japan., Hara K; Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, Saitama, Japan., Tanaka M; Department of Neurology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Ishiura H; Department of Neurology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Tsuji S; Department of Neurology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Suzuki K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Takakura M; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Boroevich KA; Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Tsunoda T; Department of Medical Science Mathematics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.; Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Shojima N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan kadowaki-3im@h.u-tokyo.ac.jp nshojima-tky@umin.ac.jp., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan kadowaki-3im@h.u-tokyo.ac.jp nshojima-tky@umin.ac.jp.
Publikováno v:
Diabetes [Diabetes] 2017 Oct; Vol. 66 (10), pp. 2713-2723. Date of Electronic Publication: 2017 Aug 01.
Autor:
Kubota N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Department of Clinical Nutrition Therapy, The University of Tokyo, Tokyo 113-8655, Japan.; Clinical Nutrition Program, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 162-8636, Japan., Kubota T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Clinical Nutrition Program, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 162-8636, Japan.; Division of Cardiovascular Medicine, Toho University, Ohashi Hospital, Tokyo 153-8515, Japan., Kajiwara E; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan., Iwamura T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan., Kumagai H; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan., Watanabe T; First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Hokkaido 060-8648, Japan., Inoue M; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Clinical Nutrition Program, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 162-8636, Japan., Takamoto I; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.; Clinical Nutrition Program, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 162-8636, Japan., Sasako T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan., Kumagai K; Animal Research Center, Tokyo Medical University, Tokyo 160-8402, Japan., Kohjima M; Department of Gastroenterology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan., Nakamuta M; Department of Gastroenterology, Clinical Research Center, National Hospital Organization Kyushu Medical Center, Fukuoka 810-8563, Japan., Moroi M; Division of Cardiovascular Medicine, Toho University, Ohashi Hospital, Tokyo 153-8515, Japan., Sugi K; Division of Cardiovascular Medicine, Toho University, Ohashi Hospital, Tokyo 153-8515, Japan., Noda T; Department of Cell Biology, Japanese Foundation for Cancer Research-Cancer Institute, Tokyo 135-8550, Japan., Terauchi Y; Department of Diabetes and Endocrinology, Yokohama City University, School of Medicine, Kanagawa 236-0004, Japan., Ueki K; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Publikováno v:
Nature communications [Nat Commun] 2016 Oct 06; Vol. 7, pp. 12977. Date of Electronic Publication: 2016 Oct 06.
Autor:
Obata A; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Kubota N; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Kubota T; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Iwamoto M; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Sato H; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Sakurai Y; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Takamoto I; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Katsuyama H; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Suzuki Y; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Fukazawa M; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Ikeda S; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Iwayama K; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Tokuyama K; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Ueki K; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases (A.O., N.K., T.Ku., M.I., H.S., Y.Sa., I.T., H.K., K.U., T.Ka.), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan; Translational Systems Biology and Medicine Initiative (N.K., T.Ka.), The University of Tokyo, Tokyo 113-8655, Japan; Clinical Nutrition Program (N.K., T.Ku.), National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka 567-0085, Japan; Laboratory for Metabolic Homeostasis (N.K., T.Ku.), Research Center of Allergy and Immunology, RIKEN Center for Integrative Medical Sciences, Kanagawa 230-0045, Japan; Division of Cardiovascular Medicine (T.Ku.), Toho University, Ohashi Hospital, Tokyo 153-8515, Japan; Research Division (Y.Su., M.F., S.I.), Chugai Pharmaceutical Co, Ltd, Gotemba, Shizuoka 412-8513, Japan; and Graduate School of Comprehensive Human Science (K.I., K.T.), University of Tsukuba, Tsukuba 305-8577, Japan.
Publikováno v:
Endocrinology [Endocrinology] 2016 Mar; Vol. 157 (3), pp. 1029-42. Date of Electronic Publication: 2015 Dec 29.