Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Joan J. Guinovart"'
Publikováno v:
FEBS Lett
Glycogen shortage during fasting coincides with dramatic changes in hepatic adenine nucleotide levels. The aim of this work was to study the relevance of liver glycogen in the regulation of the hepatic energy state during food deprivation. To this en
Publikováno v:
The Journal of Biological Chemistry
Hepatic glycogen metabolism is impaired in diabetes. We previously demonstrated that strategies to increase liver glycogen content in a high-fat-diet mouse model of obesity and insulin resistance led to a reduction in food intake and ameliorated obes
Publikováno v:
Diabetologia. 60:1076-1083
Liver glycogen plays a key role in regulating food intake and blood glucose. Mice that accumulate large amounts of this polysaccharide in the liver are protected from high-fat diet (HFD)-induced obesity by reduced food intake. Furthermore, these anim
Autor:
Felipe Slebe, Mar García-Rocha, Rosa Gasa, Jordi Duran, Ramon Gomis, Joan J. Guinovart, Joan Mir-Coll
Publikováno v:
Diabetologia. 59:1012-1020
Glycogen accumulation occurs in beta cells of diabetic patients and has been proposed to partly mediate glucotoxicity-induced beta cell dysfunction. However, the role of glycogen metabolism in beta cell function and its contribution to diabetes patho
Autor:
Ainhoa Garcia, Sandra A. Rebuffat, Delia Zafra, Deborah J. Burks, Rosa Gasa, Susana G. Kalko, Joana Moitinho Oliveira, Joan J. Guinovart, Ramon Gomis
Publikováno v:
AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2014, 306 (1), pp.E36-E47. ⟨10.1152/ajpendo.00409.2013⟩
AJP-Endocrinology and Metabolism, American Physiological Society, 2014, 306 (1), pp.E36-E47. ⟨10.1152/ajpendo.00409.2013⟩
Pancreatic β-cells play a central role in type 2 diabetes (T2D) development, which is characterized by the progressive decline of the functional β-cell mass that is associated mainly with increased β-cell apoptosis. Thus, understanding how to enha
Autor:
J.P. Pontigo, Juan C. Slebe, Ilona I. Concha, Romina Bertinat, Rody San Martín, Moisés Pérez, Alejandro J. Yáñez, Joan J. Guinovart
Publikováno v:
JOURNAL OF CELLULAR BIOCHEMISTRY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
MOLECULAR AND CELLULAR BIOCHEMISTRY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
MOLECULAR AND CELLULAR BIOCHEMISTRY
Using a streptozotocin-induced type 1 diabetic rat model, we analyzed and separated the effects of hyperglycemia and hyperinsulinemia over the in vivo expression and subcellular localization of hepatic fructose 1,6-bisphosphatase (FBPase) in the mult
Publikováno v:
Diabetologia. 54:2639-2648
Glycogen deposition is impaired in diabetes, thus contributing to the development of hyperglycaemia. Several glucose-lowering strategies have attempted to increase liver glycogen deposition by modulating targets, which eventually trigger the activati
Autor:
Joan Ballester, Teresa Rigau, Jorge Domínguez, Joan E. Rodríguez-Gil, Meritxell Sensat, Joan J. Guinovart, M. Carmen Muñoz
Publikováno v:
Journal of Andrology. 26:706-715
Oral administration of sodium tungstate to adult male streptozotocin-diabetic rats for 3 months normalized serum levels of glucose, insulin, luteinizing hormone, and follicle-stimulating hormone. These effects were accompanied by an increase in repro
Autor:
Delia Zafra, Joan J. Guinovart, Ciro Mercurio, Rosario Perona, Albert Barberà, Isabel Sánchez-Pérez, Jorge Domínguez, Martine Caron, Mª Carmen Muñoz, Susanna Baqué, Ramon Gomis
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Sodium tungstate is a powerful antidiabetic agent when administered orally. In primary cultured hepatocytes, tungstate showed insulin-like actions, which led to an increase in glycogen synthesis and accumulation. However, this compound did not signif
Autor:
Kei Sakamoto, Carlos Martínez-Pons, David H. Wasserman, Joaquim Calbó, Li Kang, Mark Peggie, Martin Voss, Roger W. Hunter, Patricia T.W. Cohen, Kashyap A. Patel, Joan J. Guinovart, Iliana López-Soldado, Louise Lantier, Mar García-Rocha, Alexander von Wilamowitz-Moellendorff
Publikováno v:
Diabetes
The liver responds to an increase in blood glucose levels in the postprandial state by uptake of glucose and conversion to glycogen. Liver glycogen synthase (GYS2), a key enzyme in glycogen synthesis, is controlled by a complex interplay between the