Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Itaru Kojima"'
Publikováno v:
Endocrinology and Metabolism, Vol 29, Iss 1, Pp 12-19 (2014)
The sweet taste receptors present in the taste buds are heterodimers comprised of T1R2 and T1R3. This receptor is also expressed in pancreatic β-cells. When the expression of receptor subunits is determined in β-cells by quantitative reverse transc
Externí odkaz:
https://doaj.org/article/fb8c60407d944c80b5f9836df728b829
Autor:
Itaru Kojima, Yuko Nakagawa
Publikováno v:
Diabetes & Metabolism Journal, Vol 35, Iss 5, Pp 451-457 (2011)
The sweet taste receptor is expressed in taste cells located in taste buds of the tongue. This receptor senses sweet substances in the oral cavity, activates taste cells, and transmits the taste signals to adjacent neurons. The sweet taste receptor i
Externí odkaz:
https://doaj.org/article/bbe4e4f54dbc4b24915809ee7c9e49e2
Publikováno v:
Endocrine Journal. 69:487-493
T1R3 is a class C G protein-coupled receptor family member that forms heterodimeric umami and sweet taste receptors with T1R1 and T1R2, respectively, in the taste cells of taste buds. T1R3 is expressed in 3T3-L1 cells in homomeric form and negatively
Publikováno v:
Pflugers Archiv : European journal of physiology. 471(4)
Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effe
Autor:
Shigeki Takeda, Aya Kurosawa, Itaru Kojima, Michinari Otobe, Hideki Sezutsu, Nobuo Kuwabara, Rina Enomoto, Mizuko Futahashi, Yusuke Inoue, Nozomi Nakajima, Tadahiro Kitamura, Misaki Mashiko, Yoshiaki Nikaido, Osamu Kikuchi, Satoshi Kuroiwa, Kazuya Tooyama, Hiroyuki Osada, Maki Ohsaki, Toshihiko Saheki, Yuko Nakagawa, Tamio Saito
Publikováno v:
European journal of pharmacology. 814
GPBA is a G protein–coupled receptor that is activated by bile acids. Because activation of GPBA leads to increased cAMP levels and secretion of incretins and insulin, GPBA has been proposed as a promising drug target for the treatment of metabolic
Publikováno v:
Diabetes, obesitymetabolism. 19
Glucose is a primary stimulator of insulin secretion. It has been thought that glucose exerts its effect by a mechanism solely dependent on glucose metabolism. We show here that glucose induces rapid Ca
Publikováno v:
Endocrinology and Metabolism, Vol 29, Iss 1, Pp 12-19 (2014)
Endocrinology and Metabolism
Endocrinology and Metabolism
The sweet taste receptors present in the taste buds are heterodimers comprised of T1R2 and T1R3. This receptor is also expressed in pancreatic β-cells. When the expression of receptor subunits is determined in β-cells by quantitative reverse transc
Publikováno v:
Biochemical and Biophysical Research Communications. 416:58-63
GPR119 is one of the G-protein-coupled receptors expressed in pancreatic β-cells and intestinal endocrine cells. Since agonists to GPR119 stimulate glucose-dependent insulin secretion, GPR119 agonists are anticipated to promote anti-diabetic effects
Autor:
Toshiyuki Takeuchi, Itaru Kojima, Hiromi Hashimoto, Satoko Yamada, Izumi Takei, Etsuko Hisanaga, Kee Yong Park, Kazuo Umezawa, Masaharu Seno, Masatomo Mori
Publikováno v:
Endocrine Journal. 55:535-543
The present study was conducted to establish a method to induce differentiation of bone marrow (MB)-derived mesenchymal cells into insulin-producing cells. When mouse BM-derived mesenchymal cells were cultured for 60 days in medium containing 10% fet
Autor:
Hideaki Kaneto, Yoshimitsu Yamasaki, Itaru Kojima, Taka-aki Matsuoka, Masatsugu Hori, Eva Henderson, Takeshi Miyatsuka, Roland Stein, Munehide Matsuhisa, Dan Kawamori
Publikováno v:
Molecular Endocrinology. 21:2764-2774
Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and principal phase of insulin-expressing cell production during pancreas organogenesis and is the only transcriptional activator present exclusively in islet