Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Stephen S Whitehead"'
Autor:
Leslie Goo, Pavle S. Milutinovic, Christina R. DeMaso, Kimberly A. Dowd, Theodore C. Pierson, Laura A. VanBlargan, Stephen S. Whitehead, Anna P. Durbin
Publikováno v:
J Virol
Dengue virus cocirculates globally as four serotypes (DENV1 to -4) that vary up to 40% at the amino acid level. Viral strains within a serotype further cluster into multiple genotypes. Eliciting a protective tetravalent neutralizing antibody response
Autor:
Aruna D. De Silva, Alba Grifoni, Angel Balmaseda, Conner K. Kidd, James D. Brien, Stephen S. Whitehead, Hannah Voic, Anna P. Durbin, Alessandro Sette, Eva Harris, Daniela Weiskopf, Sandeep Kumar Dhanda, Anette Stryhn, Søren Buus, Sean A. Diehl
Publikováno v:
J Virol
Members of the flavivirus genus share a high level of sequence similarity and often circulate in the same geographical regions. However, whether T cells induced by one viral species cross-react with other related flaviviruses has not been globally ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d53f89312b3917146627da30d715e0
Autor:
Sebastian P. Fuchs, Diogo M. Magnani, Ronald C. Desrosiers, Maria do Carmo Sampaio Tavares Timenetsky, Priscilla R. Costa, Dennis R. Burton, Nuria Pedreño-Lopez, Martin J. Gutman, Michael J. Ricciardi, Aline Domingues, Jorge Kalil, Mauricio A. Martins, Cassia G. T. Silveira, Jens Wrammert, Helen S. Maxwell, Raphaella Goulart, Esper G. Kallas, José M. Martinez-Navio, David I. Watkins, Lucas Gonzalez-Nieto, Stephen S. Whitehead, Lilian Ferrari, Varian K. Bailey
Exposure to dengue virus (DENV) is thought to elicit lifelong immunity, mediated by DENV-neutralizing antibodies (nAbs). However, Abs generated by primary infections confer serotype-specific protection, and immunity against other serotypes develops o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b886b8dc0b1ff6c8a338e66b0ad4e751
https://europepmc.org/articles/PMC5660501/
https://europepmc.org/articles/PMC5660501/
Autor:
Wen-Yang Tsai, Jih-Jin Tsai, Wei-Kung Wang, Stephen S. Whitehead, Anna P. Durbin, Szu Chia Hsieh
Publikováno v:
Journal of Virology. 89:7348-7362
The four serotypes of dengue virus (DENV) cause the most important and rapidly emerging arboviral diseases in humans. The recent phase 2b and 3 studies of a tetravalent dengue vaccine reported a moderate efficacy despite the presence of neutralizing
Autor:
Beth D. Kirkpatrick, Patrick H. O'Rourke, Alba Grifoni, Aruna D. De Silva, Simon Mallal, Sean A. Diehl, Bjoern Peters, Stephen S. Whitehead, Sinu Paul, Anna P. Durbin, Michael A. Angelo, John Sidney, Daniela Weiskopf, Elizabeth J. Phillips, Alessandro Sette
Publikováno v:
Journal of Virology. 91
Dengue virus (DENV) is responsible for growing numbers of infections worldwide and has proven to be a significant challenge for vaccine development. We previously demonstrated that CD8 + T cell responses elicited by a dengue live attenuated virus (DL
Autor:
Simon Mallal, John Sidney, Jonathan E. Boyson, Jason Botten, Beth D. Kirkpatrick, Bjoern Peters, Stephen S. Whitehead, Sinu Paul, Anna P. Durbin, Michael A. Angelo, Alessandro Sette, Sean A. Diehl, Alba Grifoni, Aruna D. De Silva, Elizabeth J. Phillips, Daniela Weiskopf
Publikováno v:
Journal of virology. 91(8)
A deletion variant of the dengue virus (DENV) serotype 2 (DENV2) Tonga/74 strain lacking 30 nucleotides from its 3′ untranslated region (rDEN2Δ30) has previously been established for use in a controlled human DENV challenge model. To evaluate if t
Publikováno v:
Journal of virology. 89(12)
The safety and efficacy of the live-attenuated Japanese encephalitis virus (JEV) SA14-14-2 vaccine are attributed to mutations that accumulated in the viral genome during its derivation. However, little is known about the contribution that is made by
Autor:
Derek J. Bangs, Michael A. Angelo, John Sidney, Janet C. Lindow, Stephen S. Whitehead, Sean A. Diehl, Anna P. Durbin, Sinu Paul, Bjoern Peters, Daniela Weiskopf, Alessandro Sette, Aruna D. De Silva, Beth D. Kirkpatrick
Publikováno v:
Journal of virology. 89(1)
The incidence of infection with any of the four dengue virus serotypes (DENV1 to -4) has increased dramatically in the last few decades, and the lack of a treatment or vaccine has contributed to significant morbidity and mortality worldwide. A recent
Publikováno v:
Journal of Virology. 79:5516-5528
The mosquito-borne dengue (DEN) viruses, members of the Flaviviridae family, contain a single-stranded positive-sense RNA genome (36). A single polypeptide is cotranslationally processed by viral and cellular proteases generating three structural pro
Autor:
Stephen S. Whitehead, Lewis Markoff, Joseph E. Blaney, Kathryn A. Hanley, Barry Falgout, Brian R. Murphy
Publikováno v:
Journal of Virology. 77:1653-1657
The Δ30 deletion mutation, which was originally created in dengue virus type 4 (DEN4) by the removal of nucleotides 172 to 143 from the 3′ untranslated region (3′ UTR), was introduced into a homologous region of wild-type (wt) dengue virus type