Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Philip T. Liu"'
Publikováno v:
PLoS neglected tropical diseases, vol 12, iss 7
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006608 (2018)
Kim, Elliot W; Teles, Rosane MB; Haile, Salem; Liu, Philip T; & Modlin, Robert L. (2018). Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.. PLoS neglected tropical diseases, 12(7), e0006608. doi: 10.1371/journal.pntd.0006608. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6wg8k5pv
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 12, Iss 7, p e0006608 (2018)
Kim, Elliot W; Teles, Rosane MB; Haile, Salem; Liu, Philip T; & Modlin, Robert L. (2018). Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae.. PLoS neglected tropical diseases, 12(7), e0006608. doi: 10.1371/journal.pntd.0006608. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6wg8k5pv
Background The immune system depends on effector pathways to eliminate invading pathogens from the host in vivo. Macrophages (MΦ) of the innate immune system are armed with vitamin D-dependent antimicrobial responses to kill intracellular microbes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4023b30d30128e6754c351e1e50a0d
https://escholarship.org/uc/item/6wg8k5pv
https://escholarship.org/uc/item/6wg8k5pv
Autor:
Matteo Pellegrini, Avelino De Leon, Philip T. Liu, Megan S. Inkeles, Stephan R. Krutzik, Elliot W. Kim, Matthew Wheelwright
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950), vol 192, iss 5
A role for vitamin A in host defense against Mycobacterium tuberculosis has been suggested through epidemiological and in vitro studies; however, the mechanism is unclear. In this study, we demonstrate that vitamin A–triggered antimicrobial activit
Autor:
Delphine J. Lee, David M. Vu, Stephan R. Krutzik, Dennis Montoya, Peter A. Sieling, Mirjam Schenk, Philip T. Liu, Robert L. Modlin, Mario Fabri
Publikováno v:
Immunology, vol 141, iss 2
Schenk, M; Fabri, M; Krutzik, SR; Lee, DJ; Vu, DM; Sieling, PA; et al.(2014). Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells. Immunology, 141(2), 174-180. doi: 10.1111/imm.12167. UCLA: Retrieved from: http://www.escholarship.org/uc/item/3zr1d0n2
Schenk, M; Fabri, M; Krutzik, SR; Lee, DJ; Vu, DM; Sieling, PA; et al.(2014). Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells. Immunology, 141(2), 174-180. doi: 10.1111/imm.12167. UCLA: Retrieved from: http://www.escholarship.org/uc/item/3zr1d0n2
The rapid differentiation of monocytes into macrophages (MΦ) and dendritic cells is a pivotal aspect of the innate immune response. Differentiation is triggered following recognition of microbial ligands that activate pattern recognition receptors o
Autor:
Elliot W. Kim, Santhosh M. Nadipuram, Ashley L. Tetlow, William D. Barshop, Philip T. Liu, James A. Wohlschlegel, Peter J. Bradley, Ira J. Blader
Publikováno v:
mSphere
mSphere, Vol 1, Iss 2, p e00045-16 (2016)
mSphere, Vol 1, Iss 2 (2016)
mSphere, Vol 1, Iss 2, p e00045-16 (2016)
mSphere, Vol 1, Iss 2 (2016)
The interactions between intracellular microbes and their host cells can lead to the discovery of novel drug targets. During Toxoplasma infections, host cells express an array of immunity-related GTPases (IRGs) and guanylate binding proteins (GBPs) t
Publikováno v:
Clinical Reviews in Bone and Mineral Metabolism. 7:176-184
This chapter will examine the role of vitamin D in the innate immune system as a mediator of human host defense mechanisms microbial disease, focusing on tuberculosis. The first section will examine tuberculosis and the innate immune response to the
Autor:
Robert L. Modlin, John S. Adams, Juan Antonio Robles, Steffen Stenger, Stephan R. Krutzik, Martin Hewison, Philip T. Liu
Publikováno v:
The Journal of Immunology. 181:7115-7120
An essential function of the innate immune system is to directly trigger antimicrobial mechanisms to defend against invading pathogens. In humans, one such pathway involves activation by TLR2/1L leading to the vitamin D-dependent induction of antimic
Autor:
Jenny Kim, Melissa Kanchanapoomi, Dominic Ho-Ping Tang, Brian E. Hall, Jenny Phan, Stephan R. Krutzik, Philip T. Liu
Publikováno v:
The Journal of Immunology. 180:4919-4923
Propionibacterium acnes is a major etiological factor of acne, triggering an inflammatory response in part through the activation of TLR2. In this study, we demonstrate that activation of peripheral blood monocytes with P. acnes in vitro induced thei
Publikováno v:
Annals of the New York Academy of Sciences. 1117:94-105
Defensin is a generic name reserved for an endogenously synthesized antimicrobial agent. The purpose of this review is to describe a series of discoveries that led to the proposal that 25-hydroxylated metabolites of vitamin D are key, intracellular r
Autor:
Anita Baghaee, James Z. Hui, Sheila Dejbakhsh, Michelle Mahanian, George W. Bernard, Araceli Espinosa-Jeffrey, Ben Chiang, James Sayre, Pamela Hong, John M. Ringman, Philip T. Liu, Milan Fiala, John R. Cashman, Justin Zaghi, Mark J. Rosenthal, Laura Zhang
Publikováno v:
Proceedings of the National Academy of Sciences. 104:12849-12854
We have tested a hypothesis that the natural product curcuminoids, which has epidemiologic and experimental rationale for use in AD, may improve the innate immune system and increase amyloid-β (Aβ) clearance from the brain of patients with sporadic
Publikováno v:
Trends in Molecular Medicine. 13:117-124
The innate immune system provides the host with an immediate and rapid defense against invading microbes. Detection of foreign invaders is mediated by a class of receptors that are known as the pattern recognition receptors, such as the family of Tol